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Status unknownNCT03618719Updated Mar 12, 2019

Impact of Intermittent Hypoxia on the Function of the Phagocytes

An observational study in Obstructive Sleep Apnea of Adult, sponsored by Taipei Veterans General Hospital, Taiwan. Status unknown at 1 site in Taiwan. Open to participants aged 20 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-03-12.

Sponsored by Taipei Veterans General Hospital, Taiwan · Observational

The sponsor has not verified this record recently (last verified Mar 2019), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
40
Ages
20 Years and older
Sex
All
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Study summary

Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis are included as well as healthy controls without OSA. 15 cc peripheral venous blood is drawn on the date of diagnosis of OSA and 3-6 months after CPAP therapy. Granulocytes are harvested and tested for its function, such as phagocytosis, reactive oxygen species (ROS) production and bacteria-killing ability.

Read the detailed description

Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis are included. Healthy controls without OSA are enrolled, too. 15 cc peripheral venous blood is drawn on the date of diagnosis of OSA and 3-6 months after CPAP therapy (not given to controls). Granulocytes are harvested and tested for its function, such as phagocytosis, reactive oxygen species (ROS) production and bacteria-killing ability.

02

Conditions studied

  • Obstructive Sleep Apnea of Adult

Keywords

  • obstructive sleep apnea
  • intermittent hypoxia
  • granulocyte function
  • continuous positive airway pressure (CPAP) therapy
03

In context

Sleep Apnea Syndromes

2,162 studies on the registry are indexed under Sleep Apnea Syndromes; 290 are open to participants now.

This study's planned enrollment of 40 is below the median of 109 across 654 observational studies indexed under Sleep Apnea Syndromes.

Browse Sleep Apnea Syndromes studies →

Lead sponsor

Taipei Veterans General Hospital, Taiwan is the lead sponsor of 325 studies on the registry; 72 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

\<OSA group> Adult Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis are included.

\<Control group> Healthy adult controls without OSA

Inclusion criteria

\<OSA group> 1. Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis 2. aged 20 years or older 3. Apnea-hypopnea index (AHI) at least 15/hour 4. Willing to participate this study \<Control group>

  1. Healthy controls without OSA
  2. aged 20 years or older
  3. AHI less than 5/hour

Exclusion criteria

Exclusion Criteria:

\<OSA group>

  1. OSA patients who do not need continuous positive airway pressure (CPAP) therapy
  2. OSA Patients have ever received CPAP or other treatment
  3. aged less than 20 years
  4. AHI at least 15/hour
  5. Not willing to participate this study \<Control group>
  1. Apnea-hypopnea index (AHI) equals to or more than 5/hour 2. aged less than 20 years 3. Not willing to participate this study
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
40 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • Obstructive sleep apnea

    Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis

  • Control

    Healthy controls without OSA

06

What researchers measure

Primary outcomes

  1. Granuolocyte function

    Granuolocyte function, such as such as phagocytosis, reactive oxygen species (ROS) production and bacteria-killing ability.

    Time frame: On enrollment

  2. Granuolocyte function

    Granuolocyte function, such as such as phagocytosis, reactive oxygen species (ROS) production and bacteria-killing ability.

    Time frame: 3-month

  3. Granuolocyte function

    Granuolocyte function, such as such as phagocytosis, reactive oxygen species (ROS)

    Time frame: 6-month

07

Study locations

1 of 1 sites recruiting
  • Chest department, Taipei Veteran General Hospital
    Taipei City, 112, Taiwan
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 12, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT03618719
Lead sponsor
Taipei Veterans General Hospital, Taiwan
Responsible party
Sponsor
First posted
Aug 7, 2018
Start date
Mar 5, 2019
Primary completion
Jul 3, 2019 (estimated)
Completion
Jul 3, 2019 (estimated)
Last update
Mar 12, 2019

Study contacts

Kun-Ta Chou, M.D
Contact
ale1371@yahoo.com.tw
+886922407055
Kun-Ta Chou, M.D
principal investigator · Taipei Veterans General Hospital, Taiwan

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Mar 2019. You cannot join it, but the record below documents what was studied.

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