An observational study in Acne Vulgaris and Thyroid Dysfunction, sponsored by Assiut University. Status unknown at 1 site in Egypt. Open to female participants aged 16 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-07-31.
Sponsored by Assiut University · Observational
Acne is a chronic inflammatory disease of the pilo-sebaceous unit with a multi-factorial etiology. It is one of the most frequent cutaneous diseases, affecting more than eighty percent of the population at some point in their lives .
Endocrine factors especially androgens and steroids are one of multiple factors provoked to be involved in pathogenesis of acne . Thyroid hormones have steroid like action that have many regulatory functions in many body organ functions including skin and pilosebaceous unit. Furthermore, subtle thyroid dysfunction was shown to have a role in many disease conditions.
Thyroid hormone action on sebaceous glands is unclear. In hypothyroid states, sebocytes exhibit reduced rates of secretion that increases with thyroxine administration .
Most of studies about thyroid dysfunction in acne patients focused on adult acne population especially females and searched for presence or absence of associating anti-thyroid antibodies with controversial results .
Some other studies were concerned with the impact of acne treatments as tetracycline, isotretinoin or radiotherapy on thyroid pathologies and dysfunction .
Global Acne Severity Scale (GAGS) is a simple, accurate, fast method for the determination of severity of acne, and it requires no special equipment and is relatively cost-effective. Its personal and interpersonal differences is low and it was first used by Doshi and his colleagues in 1997 in USA .
To the best of knowledge, little is published about thyroid dysfunction in acne female patients of different age categories and correlating thyroid function with other important patient and acne variables as body mass index (BMI) , age (starting from 16 years) , acne type, severity and duration.
730 studies on the registry are indexed under Acne Vulgaris; 86 are open to participants now.
This study's planned enrollment of 79 is below the median of 90 across 81 observational studies indexed under Acne Vulgaris.
Browse Acne Vulgaris studies →Assiut University is the lead sponsor of 4,901 studies on the registry; 2,098 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
* group will include 50 females * Clinical examination including acne grade assessment using Global Acne Grading Scale (GAGS) * Assessment of body mass index (BMI) * blood serum samples will be collected from all patients to do thyroid function test
* group will include 29 females * Assessment of body mass index (BMI) * blood serum samples will be collected from all healthy controls to do thyroid function test
thyroid hormone level in female acne vulgaris patients
Peripheral blood samples will be taken , for measurement of thyroid hormone by ELISA
Time frame: 1 hour
Plan to share: Undecided
This study is status unknown, as verified in Jul 2018. You cannot join it, but the record below documents what was studied.
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Assiut University