An interventional study of Mass spectrometry and Microarray assay in Septicemia, sponsored by Chiang Mai University. Status unknown at 1 site in Thailand. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2018-07-11.
Sponsored by Chiang Mai University · Not applicable, Interventional, and Treatment
This is an experimental study of participants who had positive blood culture to compare time to appropriate antibiotic between using Microarray Assay and Mass Spectrometry to bacterial Identification.
Between June to Dec 2018, 200 participants those met the eligibility criteria were enrolled in this study that is a quasi experimental study. All participants were empirical antibiotic therapy by infectious physician. 100 patients in Pre-intervention group had bacterial identification by Mass spectrometry technique from bacterial colony and 100 patients in Post-intervention group had bacterial identification by Microarray assay from blood culture. Antibiotic adjustment were considered after bacterial identification and result of antibiotic susceptibility testing. Then all participants were re-evaluated outcome after treatment. Finally, the results were ready to analysis in January 2019.
1,899 studies on the registry are indexed under Sepsis; 462 are open to participants now.
This study's planned enrollment of 200 is above the median of 105 across 896 interventional studies indexed under Sepsis.
Browse Sepsis studies →Chiang Mai University is the lead sponsor of 116 studies on the registry; 11 are open to participants now.
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Exclusion Criteria:
100 participants received empiric antibiotic by ID physician, bacterial identification by Mass spectrometry technique
Diagnostic Test: Mass spectrometry
100 participants received empiric antibiotic therapy by ID physician, bacterial identification by Microarray assay from blood culture and confirm with Mass spectrometry technique
Diagnostic Test: Microarray assay
Molecular diagnostic test for bacterial identification from bacterial colony
Bacterial identification by Microarray assay from positive blood culture and confirmed by Mass spectrometry technique from bacterial colony. Adjusted antibiotic therapy according to AST Re-evaluation after treatment
To compare the time to appropriate antibiotic therapy in patients with positive blood cultures between using Microarray assays versus Mass Spectrometry technique for Identification of Positive Blood Cultures
Comparison of time that participants received appropriate antibiotic therapy between 2 study period (Mass spectrometry technique and Microarray assay group)
Time frame: 4 days from positive hemoculture
Mortality rate at 2 weeks
To compare proportion of mortality between 2 study periods (Mass spectrometry technique and Microarray assay group) at 2 weeks after enrollment
Time frame: 14 days from positive hemoculture
Length of hospital stays
To compare lengths of hospital stay between 2 study periods (Mass spectrometry technique and Microarray assay group)
Time frame: 30 days
Cost of antibiotic therapy
To compare the cost of antibiotics for the course of treatment during study period between 2 study period (Mass spectrometry technique and Microarray assay group)
Time frame: 14 days
Percentage of De-escalation or escalation antibiotic
To compare percentage of De-escalation or escalation antibiotic between 2 study periods (Mass spectrometry technique and Microarray assay group)
Time frame: 14 days
Plan to share: Undecided
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This study is status unknown, as verified in Jul 2018. You cannot join it, but the record below documents what was studied.
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Chiang Mai University