An interventional study of Dapoxetine Hydrochloride Tablet and Placebo Tablet in Premature Ejaculation, sponsored by Xidian University. Status unknown at 1 site in China. Open to male participants aged 18 Years to 64 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-08-24.
Sponsored by Xidian University · Not applicable, Interventional, and Basic science
Lifelong premature ejaculation (LPE) is a common male sexual dysfunction with a high prevalence in global. Up to now, the etiology of LPE remains unclear. In recent years, dapoxetine, a highly potent serotonin-transporter inhibitor, has been used for treating premature ejaculation. However, the underlying mechanism of dapoxetine was unknown. Recently, with widespread use of neuroimaging techniques, like positron emission tomography and magnetic resonance imaging (MRI) in basic science, researchers can acquire human data on cerebral base of human sexual behavior, not only in normal subjects but also in patients with sexual dysfunction. Therefore, in order to further understand the biological mechanism of LPE and the brain targets of dapoxetine, the present study would investigate the brain changes of LPE and the effect of dapoxetine on brain activation by using MRI technology.
2,554 studies on the registry are indexed under Premature Birth; 498 are open to participants now.
This study's planned enrollment of 100 is above the median of 84 across 1,689 interventional studies indexed under Premature Birth.
Browse Premature Birth studies →Xidian University is the lead sponsor of 13 studies on the registry; 5 are open to participants now.
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Exclusion Criteria:
In this group, patients received one dapoxetine hydrochloride tablet before MRI scan.
Drug: Dapoxetine Hydrochloride Tablet
In this group, patients received placebo tablet before MRI scan.
Drug: Placebo Tablet
oral one dapoxetine hydrochloride tablet before MRI scan
oral one placebo tablet before MRI scan.
Resting-state brain function measured by Functional magnetic resonance imaging
We will use several indicators to assess the resting-state brain function based on fMRI analysis, including regional homogeneity,Amplitude of Low Frequency Fluctuations, and functional connectivity.
Time frame: One day
This study is status unknown, as verified in May 2018. You cannot join it, but the record below documents what was studied.
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Xidian University