An interventional study of Conventional Flap surgery in Furcation Defects, sponsored by Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre. Completed at 1 site in India. Open to participants aged 30 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-11-06.
Sponsored by Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre · Not applicable, Interventional, and Treatment
This study is intended to compare the efficacy of platelet-rich fibrin as a graft and a membrane versus hyaluronic acid(Gengigel) and amniotic membrane in the treatment of mandibular grade II furcation defects.
Platelet-rich fibrin is a fraction of plasma that provides a rich source of growth factors and may enhance the stabilization and revascularization of the flaps and grafts.
Hyaluronic acid is a naturally occurring non-sulfated high molecular weight glycosaminoglycan that forms a critical component of the extracellular matrix and contributes significantly to tissue hydrodynamics, cell migration and proliferation. Hence its administration to periodontal wound sites could achieve beneficial effects in periodontal tissue regeneration.
Amniotic membrane is being used for various regenerative procedures as it is a rich source of various collagen and non-collagen proteins such as laminin, fibronectin and proteoglycan.
42 studies on the registry are indexed under Furcation Defects; 13 are open to participants now.
This study's enrollment of 14 is below the median of 27 across 38 interventional studies indexed under Furcation Defects.
Browse Furcation Defects studies →Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre is the lead sponsor of 25 studies on the registry; none are open to participants now.
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Exclusion Criteria:
Group A patients will be treated with conventional flap surgery. The furcation defects will be debrided and autologous platelet-rich fibrin will be paced as a graft and membrane. Later the flap will be sutured.
Procedure: Conventional Flap surgery
Group B patients will be treated with conventional flap surgery. The furcation defects will be debrided and Hyaluronic acid (Gengigel) will be placed as a graft. Amniotic membrane (Tata Memorial Hospital Mumbai) will be placed over the graft and later the flap will be sutured.
Procedure: Conventional Flap surgery
After administering local anaesthetic a full thickness flap will be raised and reflected to expose the furcation defects. The furcation defects would then be debrided and the graft and membrane secured in position. Later the flap would be sutured back.
Radiological Parameters
Amount of Bone fill in the furcation (Change in Bone level) to be measured by Cone Beam Computed Tomography(CBCT)
Time frame: Baseline and 9 months post surgery.
Clinical Parameter
Change in relative vertical clinical attachment level will be measured by Williams probe in millimeters in the furcation area.
Time frame: Baseline and 9 months post surgery.
Clinical Parameter
Change in relative horizontal clinical attachment level will be measured in millimeters by the Nabers probe in the furcation area
Time frame: Baseline and 9 months post surgery
Plan to share: No
Ran from Nov 2017 to primary completion in Aug 2018, 9 months.
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This study is completed, as verified in Nov 2018. You cannot join it, but the record below documents what was studied.
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Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre