A Phase 2/3 interventional study of Dialysis Solutions in Renal Insufficiency, Chronic and Inflammation, sponsored by A.O.U. Città della Salute e della Scienza. Completed at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2018-07-09.
Sponsored by A.O.U. Città della Salute e della Scienza · Phase 2/3, Interventional, and Treatment
In this study 45 patients undergoing weekly dialysis for chronic end stage renal disease will be enrolled. The patients will be treated with a standard dialysis solution, containing acetate buffer, for 3 months; subsequently the acetate will be substituted with citrate anion for the 3 following months and then, the last 3 months, the standard acetate-solution will be restarted. The aim of the study is to assess if acetate-to-citrate switch in the dialysis solution influences dialysis efficiency and patient inflammatory state.
1,995 studies on the registry are indexed under Renal Insufficiency; 173 are open to participants now.
This study's enrollment of 45 is close to the median of 43 across 1,504 interventional studies indexed under Renal Insufficiency.
Browse Renal Insufficiency studies →A.O.U. Città della Salute e della Scienza is the lead sponsor of 63 studies on the registry; 13 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Drug: Dialysis Solutions
Solution A: 3mmol/L of acetate anion; Solution B: 1mmol/L of citrate anion
Change in serum CRP (C-reactive protein)
Change in serum CRP during the 3 months of citrate-buffered dialysis
Time frame: Months 4th to 6th
Change in dialysis efficiency
Dougirdas formula will be used to estimate dialysis efficiency at the beginning and completion of each study interval
Time frame: Every 3 months (month 0, 6, 3 and completion - 9)
Change in serum CRP (C-reactive protein)
Variation of serum CRP at the beginning and completion of each study interval
Time frame: Every 3 months (month 0, 6, 3 and completion - 9)
Plan to share: No
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This study is completed, as verified in Jul 2018. You cannot join it, but the record below documents what was studied.
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A.O.U. Città della Salute e della Scienza