An observational study in Metabolic Syndrome, Diabetes Mellitus and Inflammatory Response, sponsored by Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado. Status unknown. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2018-07-05.
Sponsored by Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado · Observational
This study evaluates the relationship between the adipose tissue, as an active component, which can define metabolic phenotypes linked to cardiovascular risk modification post bariatric surgery.
Bariatric surgery induces a significant reduction in co-morbidities associated with obesity, such as Diabetes mellitus, dyslipidemia, liver disease, arterial hypertension, obstructive apnea and cardiovascular risk. However this does not happen in all obese patients, even when there is a weight reduction.
It is known that the adipose tissue is actively involved in synthesis of cytokines and its role in metabolic phenotypes has been suggested. It is possible that the intrinsic mechanisms of adipose tissue participate in several benefits observed in morbidly obese patients who undergo to an anti-obesity surgery.
So this study explores the involvement of adipose tissue as an active component, which can define metabolic phenotypes linked to cardiovascular risk modification post bariatric surgery.
1,964 studies on the registry are indexed under Metabolic Syndrome; 330 are open to participants now.
This study's planned enrollment of 70 is below the median of 200 across 458 observational studies indexed under Metabolic Syndrome.
Browse Metabolic Syndrome studies →Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado is the lead sponsor of 13 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Morbid obese patients candidates to bariatric surgery.
Exclusion Criteria:
The investigators include men and women, over 18 years old, with morbid obesity and candidates for bariatric surgery, under the routine of the treating service, with signature of acceptance of your participation, by informed consent. The investigators exclude patients with medication with potential effect on adipose tissue or cardiovascular risk in the last month, also with severe infections in the last month or clinically unstable conditions. Patients are eliminated in the study if they dont have the desire to continue in the study, and if the samples or the information are insufficient for an adequate analysis.
Procedure: Bariatric surgery
The investigators include men and women, over 18 years old, without obesity and candidates for abdominal surgery (hernioplasty, cholecystectomy, fundoplication), under the routine of the treating service, with signature of acceptance of your participation, by informed consent. The investigators exclude patients with medication with potential effect on adipose tissue or cardiovascular risk in the last month, also with severe infections in the last month or clinically unstable conditions. Patients are eliminated in the study if they dont have the desire to continue in the study, and if the samples or the information are insufficient for an adequate analysis.
Procedure: Bariatric surgery
There are two components to the procedure. First, a small stomach pouch, approximately one ounce or 30 milliliters in volume, is created by dividing the top of the stomach from the rest of the stomach. Next, the first portion of the small intestine is divided, and the bottom end of the divided small intestine is brought up and connected to the newly created small stomach pouch. The procedure is completed by connecting the top portion of the divided small intestine to the small intestine further down so that the stomach acids and digestive enzymes from the bypassed stomach and first portion of small intestine will eventually mix with the food.
Evaluate the association of the cardiovascular benefit of the obese patient after bariatric surgery with the basic mechanisms of adipose tissue (metabolic profile)
Evaluate the association of the cardiovascular benefit of the obese patient after bariatric surgery with the basic mechanisms of adipose tissue (metabolic profile)
Time frame: 3 years
Correlation between serum concentration of pro-inflammatory biomarker and the reduction of subclinical endothelial disfunction.
measurements of carotid intima-media thickness (CIMT) in millimeter and Flow mediated dilatation (FMD) in percent in a basal time and see over time the reduction (if any) of those endothelial markers
Time frame: 9 months
Determine the association of the cardiovascular prognosis modification (risk subgroups) with the basal metabolic profile.
After the 9 months follow up, the authors will correlated the pro-inflammatory cytokines, presence or absence of adipose proteins.
Time frame: 9 months
No study locations are listed for this record.
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Plan to share: Undecided
This study is status unknown, as verified in Jun 2018. You cannot join it, but the record below documents what was studied.
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Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado