An interventional study of Blood punction in Bronchopulmonary Dysplasia, sponsored by Centre Hospitalier Intercommunal Creteil. Completed at 1 site in France. Open to participants aged Up to 15 Years. Per ClinicalTrials.gov, last updated 2026-06-15.
Sponsored by Centre Hospitalier Intercommunal Creteil · Not applicable, Interventional, and Basic science
The bronchopulmonary dysplasia (BPD) is a respiratory disease of the premature child which lead to a reduction of gas exchange surface and to a prolonged respiratory failure. This disease has morphologic and functional consequences at adulthood and is today considered to be an early determinant of respiratory diseases at adulthood.
The physiopathology of BPD is not well known. Several mechanisms could be involved especially a reparation failure favored by an increase of cellular senescence which is a permanent stop of cellular proliferation. The transcription factor 16 Ink4a, considered as a marker of aging, is one of the essential markers of senescence. Its increase during prematurity was shown at the blood cells of the cordon, but its involvement in BPD and its evolution in child are not yet studied.
339 studies on the registry are indexed under Bronchopulmonary Dysplasia; 80 are open to participants now.
This study's enrollment of 80 is above the median of 70 across 228 interventional studies indexed under Bronchopulmonary Dysplasia.
Browse Bronchopulmonary Dysplasia studies →Centre Hospitalier Intercommunal Creteil is the lead sponsor of 131 studies on the registry; 36 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Premature(\< 28 GA) neonates
Term neonates:
Child from 7 to 15 years old with BPD:
Child from 7 to 15 years old without BPD:
Exclusion Criteria:
Premature (\< 28 GA) and term neonates:
-Congenital malformation
Child from 7 to 15 years old with BPD:
Child from 7 to 15 years old without BPD:
Blood punction on the cordon
Other: Blood punction
Blood punction on the cordon
Other: Blood punction
Blood punction
Other: Blood punction
Blood punction
Other: Blood punction
For the arms "Term newborns (≥37GA)" and "Premature newborns" the only intervention is a blood punction on the cordon. For the arms "Child between 7 and 15 years old" with or without BPD the only intervention is a blood punction on peripheral blood.
p16 expression
p16 expression measured by qPCR in newborns cord blood cells and in circulating leukocytes of children aged from 7 to 15
Time frame: Day 1
Telomeres length
Telomeres length of circulating leukocytes
Time frame: Day 1
Genetic expression of p21, p53, H2Ax
Genetic expression of p21, p53, H2Ax of circulating leukocytes
Time frame: Day 1
This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Intercommunal Creteil