An interventional study of clinical and biological correlates in Suicide, sponsored by Hôpital le Vinatier. Completed at 1 site in France. Open to participants aged 18 Years to 25 Years. Per ClinicalTrials.gov, last updated 2024-09-19.
Sponsored by Hôpital le Vinatier · Not applicable, Interventional, and Prevention
Suicide is the second leading cause of death among people aged 15 to 24 (WHO, 2014). After a first suicide attempt, the 18 to 25 years old would be very likely to repeat the act: 25 to 31% would make a new attempt in the following year (Christiansen et al, 2007).
Nevertheless the literature on this subject is not detailed. In this project, we hypothesize that young adults aged 18 to 25 who have made their first suicide attempt will repeat their act more frequently than younger or older populations. In addition, these young people would have identifiable risk factors (sociodemographic, clinical and biological) that differ from young people who do not enter this phenomenon.
Our main objective is to measure the rate of suicidal reiteration in a population of young adults aged 18 to 25 years.
Our secondary objectives are to identify sociodemographic, clinical and biological characteristics of a population of suicidal re attempt young people, to highlight potential risk factors
Objectives:
Our secondary objectives are to identify sociodemographic, clinical and biological characteristics of a population of suicidal young people, in an attempt to highlight potential risk factors. We will try to highlight correlations between the reiteration of the suicidal act and:
In addition, DNA and RNA genetic samples will be taken in order to constitute a biological collection for later research.
Type of study: This is an interventional research with minimal risks and constraints (2 ° study), multicenter prospective cohort.
Number of centers: 2 Suicide Prevention Center at the Le Vinatier Hospital Center and the Post Crisis Unit at the Edouard Herriot Hospital of the Hospices Civils de Lyon.
Description of the study / experimental plan:
This is a prospective cohort study that will be divided into two groups: "repeat suicide attempt" and "no repeat attempt"
Primary judgment criterion:
This is the occurrence of repeating a suicide attempt (over a period of 3 months after the initial attempt.
In this project, a suicide attempt is defined according to WHO criteria as "non-fatal suicidal behavior, self-inflicted injury with a desire to end one's life that does not lead to death".
Number of subjects:
Our study will include 200 patients at the Le Vinatier CH Suicide Prevention Center and the Post Crisis Unit at Edouard Herriot Hospital.
inclusion criteria: between the ages of 18 and 25
Exclusion Criteria:
-Majors protected: under curatorship or under guardianship
Course of the study :
-Inclusion will take place immediately after the first suicide attempt at the Post Crisis Unit at Edouard Herriot Hospital and the Suicide Prevention Center.
An anamnestic collection of social and demographic data will be carried out: level of urbanity, professional activity, level of study, access to care, and previous care received, socio-economic level, social and family context (notably existing conflict with parents or love break-up). The patient's telephone number will be collected as well as the patient's psychiatric and addiction history, and the means used for the suicide attempt.
Different scales of assessments, by means of self-questionnaires, will be given to the patient and an investigator will provide the C-SSRS scale assessment for the suicidal risk severity. Finally a venous blood sample will be performed with a measure of total and mature serum BDNF and cortisolemia. Capillary cortisol will also be measured.
After obtaining the patient's consent, two blood samples (DNA and RNA) will be collected and stored at -80 degrees to create a biological collection for later research.
An orientation in the course of care will then be given to the subject who will receive the appropriate care as well as a phone call made by the Suicide Prevention Center.
-At 3 months: A phone call will be made to check the presence or absence of the main evaluation criterion: the repetition of a suicide attempt. In addition, the patient will be asked about life events during these three months and the care received since inclusion.
Benefits and risks of this study:
The expected benefits of this study are: a better understanding of the mechanisms underlying the recurrence of the suicidal act, which could allow an optimal patient management and an adapted orientation in the care network, this for a setting in place in the near future.
In addition, patients included in the study will benefit from follow-up.
The foreseeable risk is the SR that can lead to suicide. To minimize this risk, each patient included in this protocol will benefit from a clinical evaluation performed by a trained investigator. At the end of this evaluation, according to the observed suicidal risk, an orientation in the course of care will be proposed. Each patient will be informed of the different modalities of psychiatry consultations and how to challenge the network. In addition, all patients will receive a phone call from the Suicide Prevention Center.
No serious adverse effects that could be attributed to the project are expected as part of this research.
Indeed, the blood test is carried out systematically as part of a post-suicide treatment and no other invasive examination is scheduled. The only undesirable events that can occur after a venous blood collection are: a hematoma at the point of puncture, pain during the bite, vagal discomfort or rare cases of infectious risks. These risks are greatly minimized by means of sterile single-use equipment and qualified medical personnel, and can not be considered as a serious expected adverse effect.
701 studies on the registry are indexed under Suicide; 183 are open to participants now.
This study's enrollment of 200 is above the median of 104 across 560 interventional studies indexed under Suicide.
Browse Suicide studies →Hôpital le Vinatier is the lead sponsor of 106 studies on the registry; 41 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Suicide Re Attempts in Young Adults after first suicide attempt : socio-demographic, clinical and biological correlates
Other: clinical and biological correlates
To measure the rate of suicidal re attempt (SR) in a population of young adults aged 18 to 25 years. To identify sociodemographic, clinical and biological characteristics of a population of suicidal young people, in an attempt to highlight potential risk factors
Assessment of the prevalence of SR rate over a 3-months period after the first suicide attempt, among young adults aged 18 to 25.
Time frame: Within the first 3 months following a first suicide attempt
mature and total BDNF
We will try to highlight correlations between the reiteration of the suicidal act and biological measures
Time frame: Within the first 3 months after the first suicide attempt
level of urbanity
sociodemographic risk factor
Time frame: Within the first 3 month following a first suicide attempt
socio-economic level
sociodemographic risk factor
Time frame: Within the first 3 month following a first suicide attempt
social and family context
sociodemographic risk factor
Time frame: Within the first 3 months following a first suicide attempt
date of birth
sociodemographic risk factor
Time frame: Within the first 3 months following a first suicide attempt
place of birth
sociodemographic risk factor
Time frame: Within the first 3 months following a first suicide attempt
BIS : Barratt Impulsive Scale
The Barratt Impulsiveness Scale (BIS) is a widely used measure of impulsiveness. It includes 30 items that are scored to yield six first-order factors (attention, motor, self-control, cognitive complexity, perseverance, and cognitive instability impulsiveness) and three second-order factors (attentional, motor, and non-planning impulsiveness). Clinical risk factor : We aim to highlight correlations between the reiteration of the suicidal act and different scores on clinical scales
Time frame: Within the first 3 months following a first suicide attempt
C-SSRS : Colombia Suicide Severity Rating Scale
The Screener contains 6 "yes" or "no" questions in which respondents are asked to indicate whether they have experienced several thoughts or feelings relating to suicide over the past month and behaviors over their lifetime and past 3 months. Each question addresses a different component of the respondent's suicide ideation severity and behavior. Question 1: wish to be dead Question 2: non-specific suicidal thoughts Questions 3-5: more specific suicidal thoughts and intent to act Question 6: suicidal behavior over the respondent's lifetime and past 3 months If the respondent answers "yes" to Question 2, he/she is instructed to answer Questions 3-5. If the respondent answers "no" to Question 2, he/she may skip to Question 6. An answer of "yes" to any of the six questions may indicate a need for referral to a trained mental health professional and an answer of "yes" to questions 4, 5 or 6 indicate high-risk.
Time frame: Within the first 3 months following a first suicide attempt
hair cortisol and blood cortisol
We will try to highlight correlations between the reiteration of the suicidal act and biological measures
Time frame: Within the first 3 months following a first suicide attempt
Analog visual scales
The visual analogue scale or visual analog scale (VAS) is a psychometric response scale which can be used in questionnaires. It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured. When responding to a VAS item, respondents specify their level of agreement to a statement by indicating a position along a continuous line between two end-points. Clinical risk factor : We aim to highlight correlations between the reiteration of the suicidal act and different scores on clinical scales
Time frame: Within the first 3 months following a first suicide attempt
Negative life events during the last 6 months
Clinical risk factor : We aim to highlight correlations between the reiteration of the suicidal act and different scores on clinical scales
Time frame: Within the first 3 months following a first suicide attempt
The reasons for living inventory
Clinical risk factor : We aim to highlight correlations between the reiteration of the suicidal act and different scores on clinical scales
Time frame: Within the first 3 months following a first suicide attempt
CTQ : childhood trauma questionnary
Clinical risk factor : We aim to highlight correlations between the reiteration of the suicidal act and different scores on clinical scales
Time frame: Within the first 3 months following a first suicide attempt
STAXI-2
Clinical risk factor : We aim to highlight correlations between the reiteration of the suicidal act and different scores on clinical scales
Time frame: Within the first 3 months following a first suicide attempt
PQB : psychosis risk screening
Clinical risk factor : We aim to highlight correlations between the reiteration of the suicidal act and different scores on clinical scales
Time frame: Within the first 3 months following a first suicide attempt
QIDS : Quick Inventory of Depressive Symptomatology
Clinical risk factor : We aim to highlight correlations between the reiteration of the suicidal act and different scores on clinical scales
Time frame: Within the first 3 months following a first suicide attempt
MDQ : Mood disorder questionnaire
Clinical risk factor : We aim to highlight correlations between the reiteration of the suicidal act and different scores on clinical scales
Time frame: Within the first 3 months following a first suicide attempt
CUDIT : Cannabis use Disorders Identification Test
Clinical risk factor : We aim to highlight correlations between the reiteration of the suicidal act and different scores on clinical scales
Time frame: Within the first 3 months following a first suicide attempt
CAST : Cannabis Abuse Screening Test
Clinical risk factor : We aim to highlight correlations between the reiteration of the suicidal act and different scores on clinical scales
Time frame: Within the first 3 months following a first suicide attempt
Fagerstrom Questionary
Clinical risk factor : We aim to highlight correlations between the reiteration of the suicidal act and different scores on clinical scales
Time frame: Within the first 3 months following a first suicide attempt
AUDIT : Alcohol use disorders test
Clinical risk factor : We aim to highlight correlations between the reiteration of the suicidal act and different scores on clinical scales
Time frame: Within the first 3 months following a first suicide attempt
Plan to share: No
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