An observational study in Brain Tumor and Anesthesia, sponsored by Ricard Valero. Completed at 1 site in Spain. Per ClinicalTrials.gov, last updated 2019-02-15.
Sponsored by Ricard Valero · Observational
In neurosurgery, brain tumor patients show increased levels of lactate at the beginning of surgery. This has been related to malignancy. Ki-67 is a cell proliferation index used as a marker of tumor mitotic activity.
This research aims to describe the correlation between lactate levels and the Ki-67 index in patients with brain tumor.
Lactate levels are used in the evaluation of perfusion status in critical care. Increases not related to a hypoperfusion state are observed in the patient with brain tumors. These increases have been related to type and tumor grade. This observation does not fully explain the variation within the same tumor grade.
Ki-67 label index is a marker of mitotic activity that can be used as proliferation index. It has been associated with histologic grade and survival rate. Provides a quantitative measure of the tumor proliferation status.
The investigators will perform a retrospective analysis of the clinical charts of patients after brain tumor resection. The study will address the relationship between baseline lactate levels and the proliferation index found in tissues biopsies.
1,993 studies on the registry are indexed under Brain Neoplasms; 516 are open to participants now.
This study's enrollment of 100 is close to the median of 100 across 389 observational studies indexed under Brain Neoplasms.
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Craniectomy cases for tumoral and non-tumoral surgery with lactate levels and biopsy information.
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Exclusion Criteria:
Neurosurgical patients between June 2017 and February 2018 for tumoral and non-tumoral craniectomy with lactate levels at the beginning of surgery and Ki-67 index in biopsies.
Other: Data correlation
Correlation between lactate levels and Ki-67 index
Evaluate the correlation between Lactate levels and Ki-67 Index
Levels of lactate in first blood analysis after anesthesia induction and proliferation index in biopsy results
Time frame: Within 1 week after data acquisition
Plan to share: No
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Ran from May 2018 to primary completion in Jul 2018, 2 months.
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This study is completed, as verified in Feb 2019. You cannot join it, but the record below documents what was studied.
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Ricard Valero