An interventional study of Soursop supplementation and Placebo in Blood Pressure, Prehypertension and Uric Acid, sponsored by Gadjah Mada University. Completed at 1 site in Indonesia. Open to participants aged 30 Years to 59 Years. Per ClinicalTrials.gov, last updated 2018-05-21.
Sponsored by Gadjah Mada University · Not applicable, Interventional, and Treatment
This study was a randomized controlled trial study. The aim of this study was to determine the effect of soursop fruit supplementation on blood pressure (BP), serum uric acid (SUA), and kidney function.
The definition of prehypertension and hypertension was accepted as delivered in The Seventh Report of the Joint National Committee (JNC 7) as the systolic BP was 120 - 139 mmHg and diastolic BP was 80 - 89 mmHg for prehypertension, while systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg for hypertension.
Based on the study by Sja'bani (2014), the cut-off point of (SUA) was divided into 3 categories, which are normal (\< 5 mg/dL), high-normal (5 - \<7 mg/dL), and high (≥ 7 mg/dL).
A number of 143 people with essential prehypertension and high normal uric acid level were assigned as subject in this study. Subjects were randomly assigned into two groups which are treatment and control group. For a 3 months period, the treatment group was given 2x100 g soursop fruit juice per day and the control group was left without treatment.
Blood pressure was measured by medical team using Omron HEM-907 (digital automatic blood pressure monitoring) every 2 weeks (3 times readings for each) in each subject's home. Subjects were examined in sitting position. Evaluation of laboratory examination was taken at week 0, 7 and 13.
145 studies on the registry are indexed under Prehypertension; 21 are open to participants now.
This study's enrollment of 143 is above the median of 62 across 127 interventional studies indexed under Prehypertension.
Browse Prehypertension studies →Gadjah Mada University is the lead sponsor of 62 studies on the registry; 20 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Treatment group (with soursop group) was a group which receive soursop supplementation
Dietary Supplement: Soursop supplementation
Control group (without soursop group) was a group which do not receive any intervention (placebo)
Other: Placebo
The soursop supplementation was given to treatment group (with soursop group) 2 times a day for 100 g each for 3 months period.
Control group (without soursop group) was left without treatment during study period
Change in baseline morning home blood pressure at week 7 and 13
Blood pressure was measured by medical team using Omron HEM-907 (digital automatic blood pressure monitoring) every 2 weeks (3 times readings for each) in each subject's home. Subjects were examined in sitting position.
Time frame: Week 0, 7 and 13
Change in baseline serum uric acid at week 7 and 13
Blood sample was taken to measure serum uric acid level
Time frame: Week 0, 7 and 13
Change in baseline CKD-Epi at week 7 and 13
Measurement of glomerular filtration rate
Time frame: Week 0, 7 and 13
Change in baseline uric acid excretion at week 7 and 13
24-h urine sample was taken to measure uric acid excretion
Time frame: Week 0, 7 and 13
This study is completed, as verified in May 2018. You cannot join it, but the record below documents what was studied.
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Gadjah Mada University