An interventional study of saline and Insulin in Liver Transplantation, sponsored by Central South University. Completed at 1 site in China. Per ClinicalTrials.gov, last updated 2018-05-11.
Sponsored by Central South University · Not applicable, Interventional, and Treatment
Lactic acidosis is a common phenomenon occurring during orthotopic liver transplantation (OLT), especially during the anhepatic and early postreperfusion phases. However, little drugs effectively decrease the degree of lactic acidosis when it happens. The aim of this study is to explore whether glucose-Insulin-Potassium(GIK) infusion can relieve metabolic acidosis and improve perioperative outcome in patients undergoing OLT.
Intraoperative metabolic acidosis begins soon after graft reperfusion and persists for several days. The current standard treatment for severe acidosis during OLT is NaHCO3, although it may compromise myocardial performance, exacerbate lactic acid accumulation and cause central nervous system demyelination. Surgical procedure is a primary source of endogenous lactic acid production, especially visceral ischemia originating from anhepatic stage. The present study thus hypothesized that GIK solution may improve metabolic acidosis in OLT patients through its unique effects of metabolic alleviation. Patients for orthotopic liver transplantation was enrolled and received either GIK or placebo. GIK or placebo infusion started after anesthesia induction. Intraoperative measures were mean arterial pressure, HR, arterial blood gases, lactate, glucose, Na, liver and renal function indexes. Outcome measures were time to tracheal extubation, intensive care unit, length of stay, complications, hospital length of stay, requirement for postoperative plasma transfusion, retransplantation, and perioperative mortality.
194 studies on the registry are indexed under Acidosis; 31 are open to participants now.
This study's enrollment of 80 is above the median of 53 across 124 interventional studies indexed under Acidosis.
Browse Acidosis studies →Central South University is the lead sponsor of 126 studies on the registry; 29 are open to participants now.
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Exclusion Criteria:
saline
Other: saline
glucose-Insulin-Potassium(GIK) infusion
Other: Insulin
saline
Also known as: glucose-Insulin-Potassium(GIK) infusion
degree of lactic acidosis
Blood samples for arterial blood pH, PCO2 , PO2 , base excess, hematocrit, and plasma concentrations of lactic acid and Na were analyzed
Time frame: up to 1 weeks
tracheal extubation
The time of tracheal extubation was calculated.
Time frame: up to 3 days
intensive care unit length of stay and hospital length of stay
The intensive care unit length of stay and hospital length of stay was calculated
Time frame: up to 1 month
The incidence of complications
The incidence of complications including liver dysfunction, renal dysfunction, infection, was analyzed
Time frame: up to 1 month
The incidence of retransplantation
The incidence of liver retransplantation
Time frame: up to 1 month
The incidence of perioperative mortality
The incidence of perioperative mortality
Time frame: up to 1 month
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Apr 2018. You cannot join it, but the record below documents what was studied.
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Central South University