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CompletedNCT03508778CLEARUpdated May 24, 2021

Clinical Evaluation of the FluidVision Accommodation Intraocular Lens (AIOL)

An interventional study of FluidVision AIOL and AcrySof IQ PanOptix Trifocal IOL in Cataract, sponsored by PowerVision. Completed at 1 site in South Africa. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2021-05-24.

Sponsored by PowerVision · Not applicable, Interventional, and Device feasibility

Phase
Not applicable
Study type
Interventional
Enrollment
95
Allocation
Randomized
Ages
50 Years and older
Sex
All
01

Study summary

The objective of this study is to evaluate the safety and effectiveness of an investigational IOL in providing a range of vision as compared to a commercially available trifocal IOL in subjects undergoing cataract extraction and IOL implantation.

Read the detailed description

Upon obtaining written informed consent and confirmation of subject eligibility via preoperative assessments, subjects were randomized in a 1:1 ratio to receive either the investigational IOL or the commercially available trifocal IOL in both eyes. The second eye for each subject was implanted after completion of the 1-week follow up for the first implanted eye. The expected total duration of participation for each subject was up to 14 months.

02

Conditions studied

  • Cataract

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Keywords

  • Intraocular lens
  • Eye surgery
03

Who can participate

Ages eligible
50 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Key Inclusion Criteria:

  • Require cataract extraction by phacoemulsification;
  • Corrected Distance Visual Acuity (CDVA) worse than 20/40 Snellen, or presence of visually significant lens opacity;
  • Preoperative or predicted postoperative astigmatism of ≤ 1.0 diopter.

Key Exclusion Criteria:

  • Use of current medications that may affect accommodation or confound study results;
  • Systemic disease that may increase the operative risk or confound results;
  • Ocular conditions or degenerative disorders that may predispose the subject to future complications;
  • Monocular subjects or significant permanent visual function loss in 1 eye;
  • Previous ocular surgery in either eye that may confound the results or increase the risk to the subject.
04

Study design

Phase
Not applicable
Primary purpose
Device feasibility
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
95 participants (actual)

Study arms

  • Experimental
    FluidVision

    FluidVision AIOL implanted in the capsular bag of the eye during cataract surgery. Both eyes were implanted, with the second eye surgery occurring after the Week 1 follow up for the first eye surgery.

    Device: FluidVision AIOL · Procedure: Cataract surgery

  • Active comparator
    PanOptix

    Commercially available trifocal IOL implanted in the capsular bag of the eye during cataract surgery. Both eyes were implanted, with the second eye surgery occurring after the Week 1 follow up for the first eye surgery.

    Device: AcrySof IQ PanOptix Trifocal IOL · Procedure: Cataract surgery

Interventions

  • DeviceFluidVision AIOL

    Investigational implantable medical device intended for long-term use over the lifetime of the cataract subject

  • DeviceAcrySof IQ PanOptix Trifocal IOL

    Commercially available implantable medical device intended for long-term use over the lifetime of the cataract subject

    Also known as: PanOptix

  • ProcedureCataract surgery

    Cataract surgery per investigator's standard practice

05

What researchers measure

Primary outcomes

  1. Distance Corrected Near Visual Acuity (DCNVA) at 100% Contrast - First Implanted Eye

    Visual acuity was tested at a distance of 40 centimeters with distance correction (plus or minus power) in place.

    Time frame: Month 6 postoperative

Secondary outcomes

  1. Distance Corrected Intermediate Visual Acuity (DCIVA) at 100% Contrast - First Implanted Eye

    Visual acuity was tested at a distance of 66 centimeters with distance correction (plus or minus power) in place.

    Time frame: Month 6 postoperative

  2. Distance Corrected Near Visual Acuity (DCNVA) at low contrast - First Implanted Eye

    Visual acuity was tested at a distance of 40 centimeters with distance correction (plus or minus power) in place.

    Time frame: Month 6 postoperative

  3. Percentage of Eyes with 20/32 or Better Visual Acuity Between 4 meters and 40 centimeters on the Defocus Curve

    A series of plus and minus lenses were placed over the subject's best distance manifest correction to simulate distances from far to hear.

    Time frame: Month 6 postoperative

06

Study locations

1 site
  • PowerVision Investigative Site
    Somerset West, 7130, South Africa
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT03508778
Lead sponsor
PowerVision
Responsible party
Sponsor
First posted
Apr 26, 2018
Start date
Feb 27, 2018
Primary completion
Jun 11, 2019
Completion
Dec 6, 2019
Last update
May 24, 2021

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

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