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CompletedNCT03506503Updated Feb 21, 2021

Condensed Nanofat Grafting for Treatment of Androgenetic Alopecia

An interventional study of Nanofat grafting in Androgenic Alopecia, sponsored by Jinan University Guangzhou. Completed at 1 site in China. Open to male participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-02-21.

Sponsored by Jinan University Guangzhou · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
10
Allocation
Not applicable
Ages
18 Years to 50 Years
Sex
Male
01

Study summary

Nowadays, multiple treatment modalities have been applied clinically to treat androgenic alopecia, such as Follicular unit transplantation(FUT), finasteride, platelet-rich plasma injection(PRP), etc. In this clinical trial, the investigators aim to analyze the effect of nanofat grafting on treating androgenic alopecia in male.

Read the detailed description

The investigators will treat the hair loss area of a patient by processed nanofat grafting. The participants were asked to come back 1、3、6、9、12 months after treatment for further follow-up.

Before and after the treatment, the hair and follicular will be assessed subjectively by satisfaction assessment, dermatoscope.

02

Conditions studied

  • Androgenic Alopecia

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Keywords

  • nanofat
  • hair loss
  • prp
03

In context

Alopecia

615 studies on the registry are indexed under Alopecia; 132 are open to participants now.

This study's enrollment of 10 is below the median of 45 across 516 interventional studies indexed under Alopecia.

Browse Alopecia studies →

Lead sponsor

Jinan University Guangzhou is the lead sponsor of 14 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 50 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Male patients with androgenic alopecia aging from 18 to 50.
  • No scars and wounds on the alopecia area.
  • No skin disease or serious cardiovascular disease.
  • Preoperative examinations remain healthy.

Exclusion criteria

Exclusion Criteria:

  • Serious chronic heart, liver, kidney, blood system disease
  • Allergic diseases, skin inflammation or wounds
  • Alopecia but not androgenic alopecia
  • Acute or chronic infection
  • Take anticoagulant drugs
  • Active vitiligo, psoriasis, systemic lupus erythematosus
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
10 participants (actual)

Study arms

  • Experimental
    processed Nanofat grafting

    processed autologous Nanofat will be injected into the area of the scalp with androgenic alopecia.

    Procedure: Nanofat grafting

Interventions

  • ProcedureNanofat grafting

    hair loss area will be treated by processed autologous Nanofat grafting

06

What researchers measure

Primary outcomes

  1. Dermatoscope

    the density of hair follicle and diameter of hair will be analized by dermatoscope before and after the treatment of Nanofat grafting.

    Time frame: Baseline and at1,3,6,9,12 months after the treatment

Other outcomes

  1. Satisfaction assessments

    the satisfaction will be assessed after the treatment

    Time frame: 1,3,6,12 months after treatment

07

Study locations

1 site
  • the first affiliated hospital of Jinan University
    Guangzhou, Guangdong 510000, China
08

References and documents

Publications

  • Tonnard P, Verpaele A, Peeters G, Hamdi M, Cornelissen M, Declercq H. Nanofat grafting: basic research and clinical applications. Plast Reconstr Surg. 2013 Oct;132(4):1017-1026. doi: 10.1097/PRS.0b013e31829fe1b0. PubMed 23783059 ↗
  • Won CH, Park GH, Wu X, Tran TN, Park KY, Park BS, Kim DY, Kwon O, Kim KH. The Basic Mechanism of Hair Growth Stimulation by Adipose-derived Stem Cells and Their Secretory Factors. Curr Stem Cell Res Ther. 2017;12(7):535-543. doi: 10.2174/1574888X12666170829161058. PubMed 28875863 ↗
  • Gu Z, Li Y, Li H. Use of Condensed Nanofat Combined With Fat Grafts to Treat Atrophic Scars. JAMA Facial Plast Surg. 2018 Mar 1;20(2):128-135. doi: 10.1001/jamafacial.2017.1329. PubMed 28975248 ↗

Individual participant data

Plan to share: No

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Feb 2019 to primary completion in Feb 2020, 12 months.

Of 96 non-industry interventional studies with no phase under Alopecia, half reached primary completion within 12 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 39. This study's 12 months is close to that.

Counting every sponsor, half of 154 studies reached it within 12 months; a quarter within 6 and three quarters within 26.

How these figures are worked out, and which studies are left out of them.

Registered
Apr 14, 2018
First posted
Apr 24, 2018
StartActual
Feb 27, 2019
Primary completionActual
Feb 27, 2020
CompletionActual
May 1, 2020
Last update
Feb 21, 2021
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Feb 21, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03506503
Lead sponsor
Jinan University Guangzhou
Responsible party
Hongwei Liu (professor, Jinan University Guangzhou) — Principal investigator
First posted
Apr 24, 2018
Start date
Feb 27, 2019
Primary completion
Feb 27, 2020
Completion
May 1, 2020
Last update
Feb 21, 2021

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2021. You cannot join it, but the record below documents what was studied.

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