An interventional study of Novelty facilitated extinction and Standard Extinction in Post Traumatic Stress Disorder, Anxiety Disorders and Panic Disorder, sponsored by University of Texas at Austin. Status unknown at 1 site in United States. Open to participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2018-04-13.
Sponsored by University of Texas at Austin · Not applicable, Interventional, and Basic science
Among 20 studies in Stress Disorders, Post-Traumatic by University of Texas at Austin — 6 open to participants now, 6 under way, none of them phase 3. Stress Disorders, Post-Traumatic · University of Texas at Austin.
Among the 20 studies in Stress Disorders, Post-Traumatic by University of Texas at Austin, this one is the 14th largest by planned enrollment, is one of 2 that started in 2017, is one of 15 with no phase, and was the 7th registered.
2,682 studies on the registry are indexed under Stress Disorders, Post-Traumatic; 601 are open to participants now.
This study's planned enrollment of 40 is below the median of 69 across 2,196 interventional studies indexed under Stress Disorders, Post-Traumatic.
Browse Stress Disorders, Post-Traumatic studies →6 of the 20 studies in Stress Disorders, Post-Traumatic by University of Texas at Austin are open now, in 1 country. Each count lists the studies.
Of the 417 Stress Disorders, Post-Traumatic studies recruiting now, 186 (45%) set no upper age limit and 205 (49%) stop at 75 or younger; 63 take children under 18; 89 take healthy volunteers.
This study: 18 Years to 50 Years · all sexes · no healthy volunteers.
The full table on the hub →20 studies; the count open now beside each. This study's row is marked.
First in 2005; this study’s year is marked. 2 started in 2017.
Median enrollment 65 across the 20 interventional studies. Of the 9 that completed or were terminated, 0 (0%) have results posted.
University of Texas at Austin is the lead sponsor of 328 studies on the registry; 79 are open to participants now.
Of its 10 completed or terminated interventional studies of FDA-regulated products, 5 (50%) have results posted.
2 of the studies in Stress Disorders, Post-Traumatic by University of Texas at Austin that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07060144University of Texas at AustinCognitive Processing Therapy (CPT) for Perinatal Posttraumatic Stress Disorder (PTSD) | 2027-05 |
| NCT05427708University of Texas at AustinRespiratory Training in the Treatment of Transdiagnostic Pathological Anxiety | 2027-05 |
Among the 20 studies in Stress Disorders, Post-Traumatic by University of Texas at Austin, from their registry updates:
Nothing recorded among them since 2026-09-25.
The purpose of this study is to use functional magnetic resonance imaging to investigate how the human brain learns to form associations between neutral and emotional stimuli. The study is based on the basic principles of Pavlovian conditioning.
When someone learns that a neutral stimulus (such as the sound of a bell) predicts an unpleasant stimulus (such as a mild electrical shock), the neutral stimulus takes on the properties of an emotional stimulus.
The investigators are interested in the neural processes involved in this learning in people with a clinical anxiety disorder and posttraumatic stress disorder (PTSD).
This study uses functional MRI in people with anxiety and stress-related disorders to evaluate the neural correlates of fear conditioning and extinction. During fear conditioning participants see a picture of a face that predicts a mild electrical shock to the wrist. Participants then return the next day to the scanner for a test of fear expression 24-hours after fear conditioning. The investigators are simultaneously measuring autonomic arousal in the scanner using measures of skin conductance responses (i.e., sweating).
The primary objective of this study is to evaluate different forms of Pavlovian fear extinction in patients who suffer from pathological anxiety. The investigators are interested in the effects of extinction and extinction retention over a delay in regions that are known to show abnormalities in anxiety populations. This includes the amygdala, ventromedial prefrontal cortex, and the hippocampus.
The study is testing behavioral strategies and does not include any pharmacological manipulations.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Behavioral intervention. After Pavlovian fear conditioning, the shock is omitted and replaced by a novel, surprising, and neutral auditory tone.
Behavioral: Novelty facilitated extinction
The shock is omitted during standard extinction
Behavioral: Standard Extinction
In the novelty-facilitated extinction design, the aversive outcome (i.e., mild unpleasant electrical pulse) is omitted and replaced by a low volume auditory tone.
During standard fear extinction the expected aversive outcome is omitted.
Changes in functional magnetic resonance imaging (fMRI)-BOLD (blood-oxygen-level dependent) signal in sensory, prefrontal, and limbic regions during a study on the neurobiology of Pavlovian fear conditioning in humans
We are measuring increases in the BOLD signal in response to visual stimuli during a Pavlovian conditioning task in humans.
Time frame: Only on the day of the experiment
Skin conductance responses evoked during a Pavlovian fear conditioning task in humans as an index of physiological arousal.
Electrodermal activity collected from the hand that measures increases in sweating, taken as an indicator of Pavlovian fear conditioning
Time frame: Only on the day of the experiment
Plan to share: Yes — NIMH Data Archive
Supporting information: Study protocol, Statistical analysis plan, Informed consent form
Time frame: Less than 6 months after data is collected.
Access criteria: We will upload data to the NIMH Data Archive and data will be accessible per their policy.
No publications or documents are linked to this record.
Started Aug 2017 (actual). Primary completion is estimated for Jun 2020, 34 months after the start.
Of 1,064 non-industry interventional studies with no phase under Stress Disorders, Post-Traumatic, half reached primary completion within 35 months of starting (the median), counting those still running; a quarter within 17 and three quarters within 53. This study's planned 34 months is close to that.
Counting every sponsor, half of 1,092 studies reached it within 34 months; a quarter within 17 and three quarters within 53.
How these figures are worked out, and which studies are left out of them.
This study is status unknown, as verified in Apr 2018. You cannot join it, but the record below documents what was studied.
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