An observational study in Colorectal Cancer, Inflammatory Bowel Diseases and Microbiota, sponsored by Centre hospitalier de l'Université de Montréal (CHUM). Completed at 1 site in Canada. Open to participants aged 18 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-04-12.
Sponsored by Centre hospitalier de l'Université de Montréal (CHUM) · Observational
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Among 12 studies in Colorectal Neoplasms by Centre hospitalier de l'Université de Montréal (CHUM) — 5 open to participants now, 6 under way, none of them phase 3. Colorectal Neoplasms · Centre hospitalier de l'Université de Montréal (CHUM).
Among the 12 studies in Colorectal Neoplasms by Centre hospitalier de l'Université de Montréal (CHUM), this one is one of 2 that started in 2018, is one of 4 observational ones, and was the 1st registered.
6,544 studies on the registry are indexed under Colorectal Neoplasms; 1,666 are open to participants now.
Browse Colorectal Neoplasms studies →5 of the 12 studies in Colorectal Neoplasms by Centre hospitalier de l'Université de Montréal (CHUM) are open now, in 1 country. Recruiting first, the newest first:
Centre hospitalier de l'Université de Montréal (CHUM) · Sites in Canada
Ages 18+
Centre hospitalier de l'Université de Montréal (CHUM) · Sites in Canada
Ages 18+
Centre hospitalier de l'Université de Montréal (CHUM) · Sites in Canada
Ages 18+
Centre hospitalier de l'Université de Montréal (CHUM) · Sites in Canada
Ages 18+
Centre hospitalier de l'Université de Montréal (CHUM) · Sites in Canada
Ages 18+
By country, each count listing its studies:
Of the 1,184 Colorectal Neoplasms studies recruiting now, 767 (65%) set no upper age limit and 264 (22%) stop at 75 or younger; 48 take children under 18; 124 take healthy volunteers.
This study: 18 Years to 90 Years · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
12 studies; the count open now beside each. This study's row is marked.
First in 2017; this study’s year is marked. 2 started in 2018.
This study's enrollment of 20 is below the median of 250 across 1,442 observational studies indexed under Colorectal Neoplasms.
Median enrollment 558 across the 8 interventional studies, 200 across the 4 observational. Of the 6 that completed or were terminated, 0 (0%) have results posted.
This tab as a report to print or save as PDF → With an account.
Centre hospitalier de l'Université de Montréal (CHUM) is the lead sponsor of 376 studies on the registry; 110 are open to participants now.
2 of the studies in Colorectal Neoplasms by Centre hospitalier de l'Université de Montréal (CHUM) that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06807073Centre hospitalier de l'Université de Montréal (CHUM)Complete Closure After Endoscopic Mucosal Resection of Large Non-Pedunculated Colorectal Polyps | 2027-07 |
| NCT06271941Centre hospitalier de l'Université de Montréal (CHUM)Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps | 2027-10-01 |
Add all 2 to your calendar (.ics) → With an account.
Among the 12 studies in Colorectal Neoplasms by Centre hospitalier de l'Université de Montréal (CHUM), from their registry updates:
Nothing recorded among them since 2026-09-25.
This tab as a report to print or save as PDF → With an account.
The study is based on the hypothesis that patients with postoperative anastomotic leakage have a different bacterial profile contributing to poor tissue healing, and that patients operated for colon cancer presumably have a different preoperative microbiota than healthy patients. This different composition is probably induced by the high heme level in the light intestinal tract that tumor spoliation generates.
The objective of the study is to evaluate the feasibility of a larger study to evaluate the difference between microbiota composition of patients with and without colorectal cancer, with inflammatory bowel disease and those with and without anastomotic leakage postoperatively of a colonic resection.
Stool samples will be taken from 20 patients, including 5 without intestinal pathology, 5 with colorectal cancer undergoing colorectal surgery, 5 with inflammatory bowel disease and 5 with anastomotic leakage after colectomy for colorectal cancer or inflammatory bowel disease.
The stool samples will be analyzed at CRCHUM to draw up a profile of the bacteria that make up the microbiota of each patient.
No more details required.
Participants included in groups 1,3 and 4 will be recruited at the outpatient clinic of the CHUM digestive surgery department, during the visit for evaluation prior surgery.
Participants included in group 2 will be recruited during the post surgery period, during their hospitalization in the department of digestive surgery of the CHUM.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
ALL
Group 1 (colorectal cancer patients)
Group 2 (anastomotic leak patients)
Group 3 ("healthy" patients)
Group 4 (inflammatory bowel disease patients)
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Colorectal cancer patients who will undergo a surgical resection with digestive anastomosis. Fecal sample collection for analysis before and after surgery (2 samples).
Other: Fecal sample collection for analysis
Patients having undergone surgical resection with digestive anastomosis for colorectal cancer or inflammatory bowel disease, complicated by anastomotic leakage. Fecal sample collection for analysis after surgery, once the leak is confirmed.
Other: Fecal sample collection for analysis
Patients with uncomplicated hernia pathology, without gastrointestinal comorbidity to undergo a surgery to heal this hernia without involving a gastrointestinal resection. Fecal sample collection for analysis before surgery (1 sample).
Other: Fecal sample collection for analysis
Inflammatory bowel disease patients waiting for elective surgery involving gastrointestinal resection. Fecal sample collection for analysis during surgery, directly from the bowel content (1 sample).
Other: Fecal sample collection for analysis
Fecal sample analysis will consist of the following procedure : Microbial DNA extraction, amplicon library construction, sequencing and analysis; Clustering MiSeq reads into operational taxonomic units (OTUs); Iron and heme measurements in the samples.
Evaluate the feasibility of patients' recruitment
Evaluate if we can recruit all required patients easily ; 20 patients total and 5 patients per group (Yes or No).
Time frame: 3 months
Evaluate the feasibility of fecal samples' analysis
Evaluate if we can easily perform the fecal sample analysis with the establish procedures (Yes or No).
Time frame: 3 months
Evaluation the presence of a correlation between fecal microbiota composition and the risk of anastomotic leak.
If it is possible to obtain results from the fecal samples' analysis, a possible correlation in the results will be evaluate.
Time frame: 6 months
Ran from Jan 2018 to primary completion in Apr 2018, 2 months.
Of 529 non-industry observational studies under Colorectal Neoplasms, half reached primary completion within 56 months of starting (the median), counting those still running; a quarter within 27 and three quarters within 132. This study's 2 months is below that.
Counting every sponsor, half of 646 studies reached it within 52 months; a quarter within 27 and three quarters within 104.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Mar 2018. You cannot join it, but the record below documents what was studied.
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