An observational study in Hypertension, sponsored by University of Ibadan. Completed at 1 site in Nigeria. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2018-03-26.
Sponsored by University of Ibadan · Observational
Help build ClinicalTrials.gg — short surveys, remote interviews or testing, in your language. Take part →
Among 31 studies in Hypertension with a site in Nigeria — 11 open to participants now, 14 under way, none of them phase 3. Hypertension · Nigeria.
Among the 31 studies in Hypertension with a site in Nigeria, this one is the 7th largest by enrollment of the 10 observational ones that give a count, is one of 4 that started in 2017, is one of 10 observational ones, and was the 9th registered.
6,120 studies on the registry are indexed under Hypertension; 913 are open to participants now.
Browse Hypertension studies →11 of the 31 studies in Hypertension with a site in Nigeria are open now. Recruiting first, the newest first:
Washington University School of Medicine · Sites in Nigeria
Ages 18+
Johns Hopkins University · Sites in Nigeria, United States, Ghana
Ages 18–70
Washington University School of Medicine · Sites in Nigeria
Women only
University of Leeds · Sites in Nigeria
Ages 18–70 · Healthy volunteers
AstraZeneca · Sites in Nigeria, Brazil, Chile and 17 more countries
Ages 18+
A study can be open while its sites in Nigeria have not opened yet or have stopped. Only those recruiting at a site in Nigeria →
Of the 563 Hypertension studies recruiting now, 266 (47%) set no upper age limit and 200 (36%) stop at 75 or younger; 40 take children under 18; 139 take healthy volunteers.
This study: 18 Years to 80 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
31 studies; the count open now beside each. This study's row is marked.
First in 2009; this study’s year is marked. 4 started in 2017.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 605 is above the median of 351 across 1,164 observational studies indexed under Hypertension.
Median enrollment 830 across the 21 interventional studies, 2,915 across the 10 observational. Of the 14 that completed or were terminated, 3 (21%) have results posted.
This tab as a report to print or save as PDF → With an account.
3 of 31 have an industry lead sponsor. The 10 most frequent:
University of Ibadan is the lead sponsor of 21 studies on the registry; 4 are open to participants now.
University of Ibadan has 4 studies filed under Hypertension — fewer than ten, so there is no comparison to draw.
4 of the studies in Hypertension with a site in Nigeria that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06823115Indiana UniversityAssessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0 | 2027-01 |
| NCT06659900Oregon Health and Science UniversityCommunity Vital Signs (CVS): An Integrated Community-Based Approach to Identify Undiagnosed Hypertension in Nigeria | 2027-06 |
| NCT06773299Washington University School of MedicineEnhancing Intergenerational Health in Nigeria: Peripartum as Critical Life Stage for Cardiovascular Health | 2027-10 |
| NCT07386535Washington University School of MedicineInnovative Tools to Expand Music-Inspired Strategies for Blood Pressure and Stroke Prevention | 2027-10-26 |
Add all 4 to your calendar (.ics) → With an account.
Among the 31 studies in Hypertension with a site in Nigeria, from their registry updates:
This tab as a report to print or save as PDF → With an account.
It is estimated that more than 70% of patients on antihypertensive medications do not take them as prescribed. Treatment non-adherence practice may be particularly higher in developing countries where there is poor accessibility to medicines and healthcare services, coupled with low level of awareness of the lifelong nature of hypertension treatment among patients. Optimal control of blood pressure has been reported to reduce the incidence of morbidity and mortality associated with hypertension. Thus, adoption of healthy lifestyle as well as ensuring regular and continuous adherence to prescribed medications are integral to successful management of hypertension to achieve the target blood pressure goals.
The present study comprehensively evaluated adherence to pharmacotherapy and non-pharmacological measures among ambulatory hypertensive patients attending two healthcare institutions in Sokoto, Northwestern Nigeria. Reasons for treatment non-adherence were evaluated, while perception and beliefs about hypertension and its management were also explored, with pharmacist-led patient-specific adherence education provided as appropriate to resolve the knowledge gap(s). Association between treatment adherence and blood pressure outcome at contact and the subsequent 2-months clinic appointment were investigated.
Patients aged 18 years and above, with a primary diagnosis of hypertension, and who were on antihypertensive medications for at least 3-months were recruited from the medical outpatient clinic of Usmanu Danfodiyo University Teaching Hospital and the Specialist Hospital, both within Sokoto metropolis, Sokoto state, Northwestern Nigeria. Newly diagnosed patients, in-patients and those who declined participation were excluded from the study.
Background: Hypertension is a common cardiovascular disease worldwide, contributing 4.5% of the global disease burden and 12.8% premature deaths annually. Despite recent advances in drug therapy, majority of diagnosed hypertensive patients are poorly controlled. Reasons for inadequate control of hypertension are heterogeneous including low adherence to antihypertensive medications and lifestyle changes, low compliance with scheduled follow-up visits and suboptimal pharmacotherapy. This study evaluated adherence to pharmacotherapy and non-pharmacological measures among ambulatory hypertensive patients, reasons for treatment non-adherence were evaluated, while perception and beliefs about hypertension and its management were also explored, with pharmacist-led patient-specific adherence education provided as appropriate to resolve the knowledge gap(s). Association between treatment adherence and blood pressure outcome at contact and the subsequent 2-months clinic appointment were investigated.
Method: This study involved a cross-sectional questionnaire-guided interview and retrospective review of medical records of 605-patients from two hospitals. Nine-item modified adherence predictor scale was used to assess medication adherence. Overall adherence score to lifestyle modifications was obtained from the total scores from 4-domains of non-pharmacological measures including cigarette smoking and alcohol cessation, salt-restriction and exercise. Patient-specific adherence education was provided at contact to resolve the knowledge gap(s). Clinical-parameters especially the blood pressure values were retrieved at contact and subsequent 2-months appointment. Data were summarised using frequency, percentage, 50th percentile and mean ± standard deviation. Chi-square test was used to evaluate association between socio-demographic variables and adherence to antihypertensive medication and lifestyle recommendations. Student's t-test was used to investigate relationship between treatment adherence and blood pressure outcome at p \< 0.05 considered significant.
Ambulatory hypertensive patients
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients were given adherence education to resolve the identified deficits
Questionnaire with a nine-item adherence scale to assess the level of adherence to medication
Questionnaire with a nine-item adherence scale was used to assess the level of adherence to medication, while dichotomous Yes/No response option was used to evaluate the level of adherence to the 4-domains of non-pharmacological lifestyle modifications, specifically smoking, alcohol, exercise, and salt-restriction. Using the Statistical Package for Social Sciences version 22 at p \< 0.05 level of significance, descriptive statistics including frequency and percentage was used to summarise the data on these parameters
Time frame: 5 hours on Thursday clinic days, 16 weeks
Perception and belief about hypertension and treatment
Modified Brief Illness Perception Questionnaire, and 9-item Belief bout Medicine Questionnaire with a 5-point likert scale was used to evaluate the perception and belief of patients about hypertension and the treatment. Descriptive statistics including frequency, percentage and 50th percentile was used to summarise the data on perception and belief about hypertension and treatment, using the Statistical Package for Social Sciences version 22.
Time frame: 5 hours on Thursday clinic days, 16 weeks
Data collection form to retrieve the average of two consecutive blood pressure readings (Systolic and Diastolic)
Data collection form was designed to retrieve the average of two consecutive blood pressure readings (Systolic and Diastolic) in individual patient's case note at contact and at the 2-months clinic appointment. Descriptive statistics including frequency, mean ± standard deviation was used to summarise these continuous variable data Chi-square and student's t-test were used to evaluate the relationship between treatment adherence and blood pressure outcome
Time frame: 4 hours on Thursday clinic days, 16 weeks
Ran from Feb 2017 to primary completion in May 2017, 3 months.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Mar 2018. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Ibadan