An interventional study of Physical Activity and Successful Aging in Aging, sponsored by Pennington Biomedical Research Center. Completed at 1 site in United States. Open to participants aged 65 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-06-25.
Sponsored by Pennington Biomedical Research Center · Not applicable, Interventional, and Prevention
Among 39 studies in Motor Activity by Pennington Biomedical Research Center — 2 open to participants now, 3 under way, none of them phase 3. Motor Activity · Pennington Biomedical Research Center.
Among the 39 studies in Motor Activity by Pennington Biomedical Research Center, this one is the 10th largest by enrollment of the 27 interventional ones that give a count, is one of 5 that started in 2018, is one of 23 with no phase, and was the 28th registered.
9,798 studies on the registry are indexed under Motor Activity; 1,910 are open to participants now.
Browse Motor Activity studies →2 of the 39 studies in Motor Activity by Pennington Biomedical Research Center are open now, in 1 country. Recruiting first, the newest first:
Pennington Biomedical Research Center · Sites in United States
Pennington Biomedical Research Center · Sites in United States
By country, each count listing its studies:
Of the 1,201 Motor Activity studies recruiting now, 517 (43%) set no upper age limit and 535 (45%) stop at 75 or younger; 180 take children under 18; 420 take healthy volunteers.
This study: 65 Years to 85 Years · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
39 studies; the count open now beside each. This study's row is marked.
First in 2007; this study’s year is marked. 5 started in 2018.
This study's enrollment of 56 is close to the median of 60 across 8,388 interventional studies indexed under Motor Activity.
Median enrollment 41 across the 27 interventional studies, 57 across the 12 observational. Of the 36 that completed or were terminated, 13 (36%) have results posted.
This tab as a report to print or save as PDF → With an account.
Pennington Biomedical Research Center is the lead sponsor of 284 studies on the registry; 31 are open to participants now.
None of the studies under way reaches primary completion within a year.
Among the 39 studies in Motor Activity by Pennington Biomedical Research Center, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The study is designed to develop and evaluate a physical activity promotion program among elderly African Americans with a long-term goal of reducing risk of Alzheimer's disease. The motivation for this study is that previous exercise interventions have improved cognitive function in older adults with and without cognitive impairments, but these studies were largely conducted without substantial African American representation. Due to genetic and environmental differences between African American and other populations, it is unclear whether positive findings from previous interventions will translate to African American individuals. Investigators hypothesize that a community-based physical activity intervention will a) be tailored to African American adults, b) increase daily amounts of physical activity, and c) improve cognitive function in sedentary older African American adults.
Investigators will randomize 56 older African American adults into 1) a physical activity intervention specifically tailored to older African American or 2) a successful aging group. The 12-week physical activity intervention will consist of group based exercise sessions at a community facility and the successful aging groups will occur at Pennington Biomedical. Cognitive functioning and blood markers of circulating neurotrophic factors will be assessed to determine the brain effects of physical activity in this understudied population.
Specific Aim 1: To tailor a physical activity promotion intervention to community-dwelling African American elderly adults. Investigators will use focus groups to gather information needed to tailor a physical activity program to elderly African Americans.
Specific Aim 2: To determine if a physical activity promotion intervention in African American adults is effective in modifying physical activity and biological markers.
Specific Aim 3: To determine if a physical activity promotion intervention in African American adults benefits cognition and brain health. Change over the course of the intervention will be assessed in key AD related cognitive domains (memory, executive function, and processing speed).
Collecting this data sets the stage for the definitive study of exercise benefits on measures of amyloid, tau, inflammation, brain metabolism, and other AD-relevant pathways in elderly African Americans, which could in turn increase understanding of neurobiological mechanisms and optimal physical activity recommendations for elderly African Americans.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The intervention will be a 12-week community-based physical activity promotion program
Behavioral: Physical Activity
Those randomized to the successful aging group will receive health information pertinent to African Americans over the 12 weeks
Other: Successful Aging
Aerobic, strength training, balance, flexibility
Healthy aging education
Change in steps.
Steps will be measured by the abtigraph WGT3X+ accelerometer.
Time frame: 7-day period
Change in dementia screening.
The Mini-Mental State Examination (MMSE) is a 30-item measure of cognitive function. Scores range from 0-30, higher scores represent better global cognitive functioning.
Time frame: Week 0 and Week 12
Change in cognition.
The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) is a brief, individually administered battery to measure cognitive decline or improvement. Four subtests of the full battery of 12 subtests used to assess immediate memory (List Learning and Story Memory), as well as language capacities (i.e., Picture Naming and Semantic Fluency). T-scores are derived, higher scores represent better functioning.
Time frame: Week 0 and Week 12
Change in quality of life.
The Health Related Quality of Life questionnaire consists of 27 questions.
Time frame: Week 0 and Week 12
Change in health care utilization.
The Health Care Utilization questionnaire consists of 12 questions. Participants report utilization of various health care avenues.
Time frame: Week 0 and Week 12
Change in depressive symptoms.
The Geriatric Depression Scale (GDS) measures depressive symptoms specifically in an elderly population. Total scores range from 0 (no depressive symptoms) to 15 (indicative of depression).
Time frame: Week 0 and Week 12
Change in resilience.
The 25-item Connor-Davidson Resilience Scale (CD-RISC 25) collects information on resilience, which is the ability to thrive despite adversity. The total score ranges from 0 (low resilience) to 100 (higher resilience)
Time frame: Week 0 and Week 12
Tailored physical activity program for elderly African American adults
Use focus groups to gather information needed to tailor a physical activity program
Time frame: 1.5 hour focus groups prior to RCT. Recruitment, retention and protocol compliance throughout the intervention
Plan to share: No
Ran from Feb 2018 to primary completion in Jun 2019, 16 months.
Of 5,147 non-industry interventional studies with no phase under Motor Activity, half reached primary completion within 17 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 36. This study's 16 months is close to that.
Counting every sponsor, half of 5,207 studies reached it within 17 months; a quarter within 7 and three quarters within 36.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jun 2020. You cannot join it, but the record below documents what was studied.
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