An observational study in Premature Ovarian Failure, Primary Ovarian Insufficiency and Ovarian Dysgenesis, sponsored by The First Affiliated Hospital of Anhui Medical University. Status unknown at 1 site in China. Open to female participants. Per ClinicalTrials.gov, last updated 2021-02-21.
Sponsored by The First Affiliated Hospital of Anhui Medical University · Observational
genetic screening and etiological analysis was conducted on patients with ovarian insufficiency and decline in ovarian reserve. All patients were enrolled in the IVF-treated and non-IVF-treated groups, followed up for long-term treatment outcomes and genomic screening.
The cause of ovarian insufficiency and decline in ovarian reserve are not clear, but most researchers think the probable causes are mainly three aspects: chromosomal abnormalities, genetic factors and autoimmune diseases，But the majority of patients with normal chromosome karyotype analysis. The screening of pathogenic genes in patients with normal karyotype is the focus of current premature ovarian insufficiency(POI) and decline in ovarian reserve(DOR) etiology, to further explain the pathogenesis of patients, improve the diagnosis of those diseases and Clinical treatment.
Patients who come to the First Affiliated Hospital of Anhui Medical University Reproductive Center and diagnosed as "premature ovarian insufficiency", "diminished ovarian reserve", "primary amenorrhea", " ovarian dysgenesis", " repeated implantation failure"，Understand the content of the project and sign an informed consent form
Exclusion Criteria:
Patients treated with IVF. IVF promotion process, ovulation, fertilization, embryo quality, transplantation and final outcome were collected after the treatment cycle was completed.
Procedure: IVF treatment
the patients who did not have received IVF treatment .Patients were followed up to collect hormone levels, ultrasound results.
Relationship between IVF treatment outcome and genotypes in POI//DOR/ovarian dysgenesis patients
Also known as: No IVF treatment
Genotype
Measure the genotype by genome-wide sequencing of exomes(WES) in subjects.
Time frame: 1/4/2018-24/12/2020
Dimensions of uterus
Measure the vertical diameter，transverse diameter and anteroposterior diameter of uterus in millimeters
Time frame: 1/4/2018-24/12/2020
Antral follicle count
Measure the basic antral follicle count before controlled ovarian hyperstimulation.
Time frame: 1/4/2018-24/12/2020
Endometrial thickness
Measure endometrial thickness of subjects in millimeters.
Time frame: 1/4/2018-24/12/2020
Live birth rate
Record the live birth rate of offspring in in both groups.
Time frame: 1/4/2018-24/12/2020
Neonatal weight
Record the neonatal weight(in kilogram) of offspring in two groups.
Time frame: 1/4/2018-24/12/2020
This study is status unknown, as verified in Jul 2020. You cannot join it, but the record below documents what was studied.
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Primary Ovarian Insufficiency→
The First Affiliated Hospital of Anhui Medical University