An interventional study of Cracked whole wheat porridge and Semolina wheat porridge in Obesity, Diabetes Mellitus, Type 2 and Appetitive Behavior, sponsored by Purdue University. Completed at 1 site in United States. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-03-19.
Sponsored by Purdue University · Not applicable, Interventional, and Basic science
Whole grains have been associated with controlled glycemic response and increased satiety compared to refined grains. However, the properties of whole grains which are responsible for these purported improved health outcomes are still unclear. The current study investigated the extent of whole grains' low glycemic property when food properties are controlled, and how this relates to gastric emptying rate and glycemic response.
It is generally assumed that whole grain foods confer a health benefit in regards to moderated glycemia and increased satiety compared to foods made from refined grains. However, the extent of whole grains' low glycemic property may be limited by certain factors. For example, physical properties such as viscosity or particle size and differing starch digestion rates of whole grain foods may strongly influence glycemic response and gastric emptying rate. In this study, whole and refined grain wheat porridges were prepared from materials originating from the same milling source, with matched pairs for viscosity, starch and dietary fiber contents, and particle size. Subjects consumed wheat porridges containing 13C-labeled octanoic acid for assessment of gastric emptying rate, and they wore a continuous glucose monitor for measuring postprandial glucose levels. The purpose of this research was to test the hypothesis that the purported moderated glycemic response and slow gastric emptying rate are dependent on how these foods are processed. This work highlights the need to consider specific properties of whole grain foods for desired health outcomes in order to optimize the design of whole grain-based foods.
11,522 studies on the registry are indexed under Obesity; 2,033 are open to participants now.
This study's enrollment of 16 is below the median of 67 across 9,006 interventional studies indexed under Obesity.
Browse Obesity studies →Purdue University is the lead sponsor of 175 studies on the registry; 21 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Large particle whole wheat porridge
Other: Cracked whole wheat porridge
Large particle refined wheat porridge
Other: Semolina wheat porridge
Small particle whole wheat porridge
Other: Whole wheat flour porridge
Small particle refined wheat porridge
Other: Refined wheat flour porridge
Small particle refined wheat porridge with small particle bran
Other: Refined wheat flour porridge,fine bran
Small particle refined wheat porridge with large particle bran
Other: Refined wheat flour porridge,coarse bran
Large particle whole wheat porridge was tested for gastric emptying rate, glycemic response and appetitive response.
Large particle refined wheat porridge was tested for gastric emptying rate, glycemic response and appetitive response.
Small particle whole wheat porridge was tested for gastric emptying rate, glycemic response and appetitive response.
Small particle refined wheat porridge was tested for gastric emptying rate, glycemic response and appetitive response.
Small particle refined wheat porridge with small particle bran was tested for gastric emptying rate, glycemic response and appetitive response.
Small particle refined wheat porridge with large particle bran was tested for gastric emptying rate, glycemic response and appetitive response.
Gastric emptying
Breath test was performed using 13C-octanoic acid mixed into test meals
Time frame: Acute study, 4 hours measurement after consumption of test food
Glycemic response
Blood glucose was measured using a continuous glucose monitor
Time frame: Acute study, 4 hours measurement after consumption of test food
Appetitive behavior
Hunger and fullness scores using a 10 cm scale (0 = weakest feeling of hunger or fullness and 10 = highest feeling of hunger or fullness) will be taken after each meal.
Time frame: Acute study, 4 hours measurement after consumption of test food.
Ran from Feb 2017 to primary completion in May 2017, 3 months.
Of 3,680 non-industry interventional studies with no phase under Obesity, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 43. This study's 3 months is below that.
Counting every sponsor, half of 3,843 studies reached it within 22 months; a quarter within 10 and three quarters within 42.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Mar 2018. You cannot join it, but the record below documents what was studied.
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