An interventional study of High-flux hemodialysis and Hemodiafiltration in Chronic Kidney Failure, sponsored by Guangdong Provincial People's Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 79 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-03-07.
Sponsored by Guangdong Provincial People's Hospital · Not applicable, Interventional, and Treatment
This study evaluates the effect of high-flux hemodialysis compared to hemodiafiltration on small and moderate molecule substances clearance. Meanwhile, this study evaluates the effect of high-flux hemodialysis compared to hemodiafiltration on cardiac function. In this self matching study, participants will receive high-flux hemodialysis compared to hemodiafiltration.
Hemodialysis using diffusion, ultrafiltration and convection principle to remove harmful substances in the blood and excessive water, is one of the most commonly replacement therapy.
Hemodiafiltration is a combination of hemodialysis and hemofiltration with two modes of treatment advantages, both by diffusion and convection principle to remove harmful substances in the blood.
Exclusion Criteria:
High-flux hemodialysis lasting for 4 hours
Other: High-flux hemodialysis
Hemodiafiltration lasting for 4 hours
Other: Hemodiafiltration
High-flux hemodialysis using diffusion, ultrafiltration and convection principle to remove harmful substances in the blood and excessive water.
Hemodiafiltration is a combination of hemodialysis and hemofiltration with two modes of treatment advantages, both by diffusion and convection principle to remove harmful substances in the blood.
Clearance of moderate molecule substance
Clearance rate of b2-microglobulin for one dialysis.
Time frame: 4 hours after dialysis
Left ventricular ejection fraction
Left ventricular ejection fraction is calculated by dividing the volume of blood pumped from the left ventricle per beat, also known as stroke volume, by the end-diastolic volume.
Time frame: 4 hours after dialysis
Plan to share: Undecided — Supporting Information: study protocol, statistic analysis plan, informed consent form, clinical study report. Time Frame: Data will be available within 1 year of study completion. Access Criteria: Data access requests will be reviewed by an external Independent Review panel. Requestors will be required to sign a Data Access Agreement.
No publications or documents are linked to this record.
This study is status unknown, as verified in Feb 2018. You cannot join it, but the record below documents what was studied.
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Guangdong Provincial People's Hospital