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CompletedNCT03446755Updated Jul 2, 2021

Use of an Intra Uterine Balloon to Prevent Recurrent Adhesions (REpAIR)

An interventional study of intra uterine Cook balloon in Adhesion; Uterus, Internal, sponsored by University Hospital, Ghent. Completed at 1 site in Belgium. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2021-07-02.

Sponsored by University Hospital, Ghent · Not applicable, Interventional, and Device feasibility

Phase
Not applicable
Study type
Interventional
Enrollment
10
Allocation
Not applicable
Ages
18 Years to 45 Years
Sex
Female
01

Study summary

Patients suffering of subfertility as a consequence of intrauterine adhesions could be treated with hysteroscopic adhesiolysis. Adhesion recurrence may occur postoperative. An intrauterine balloon, inserted after hysteroscopic adhesiolysis, may prevent adhesion reformation.

A Foley catheter can serve for this purpose, but its not ideal. COOK medical® developed a hearth shaped intrauterine balloon to reduce bleeding after intrauterine surgery.

We aimed to perform a pilot study of 10 procedures with insertion of a hearth shaped intrauterine balloon as antiadhesion method subsequent to a hysteroscopic adhesiolysis, to study its feasibility in terms of surgeon's and patient's experience.

02

Conditions studied

  • Adhesion; Uterus, Internal

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Keywords

  • antiadhesion treatment
  • Asherman's syndrome
  • hysteroscopic adhesiolysis
  • intrauterine adhesions
  • intrauterine balloon
03

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
Female
Accepts healthy volunteers
No

Eligibility criteria

Inclusion Criteria:

  • patients with intra uterine adhesions scheduled for hysteroscopic adhesiolysis
04

Study design

Phase
Not applicable
Primary purpose
Device feasibility
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
10 participants (actual)

Study arms

  • Experimental
    Intrauterine balloon (Cook medical)

    Insertion of a hearth shaped intrauterine balloon immediately after hysteroscopic adhesiolysis and left in place for 7 days under antibiotic prophylaxis.

    Device: intra uterine Cook balloon

Interventions

  • Deviceintra uterine Cook balloon

    Insertion of a hearth shaped intrauterine balloon immediately after hysteroscopic adhesiolysis and left in place for 7 days under antibiotic prophylaxis.

05

What researchers measure

Primary outcomes

  1. The number of recurrent adhesions after adhesiolysis

    Time frame: 5-10 weeks after adhesiolysis

  2. The number of complications after adhesiolysis

    Time frame: 5-10 weeks after adhesiolysis

Secondary outcomes

  1. Pain after placement of the intra uterine balloon

    via Visual Analogue Scale (VAS scale). The patient has to indicate her pain score from 0 (no pain) to 10 (worst pain ever).

    Time frame: 1 to 6 days after adhesiolysis

  2. Complications after placement of the intra uterine balloon

    Time frame: 1 to 6 days after adhesiolysis

  3. Pain at the time of the removal of the intra uterine balloon

    via Visual Analogue Scale (VAS scale). The patient has to indicate her pain score from 0 (no pain) to 10 (worst pain ever).

    Time frame: 6 days after adhesiolysis

  4. Patient Satisfaction after removal of the intra uterine balloon

    Via questionnaire

    Time frame: 6 days after adhesiolysis

  5. Malaise after placement of the intra uterine balloon

    Via questionnaire

    Time frame: 6 days after adhesiolysis

  6. Daily functioning after placement of the intra uterine balloon (absence from work, impact on work productivity, impact on household, physical activity, daily life)

    Via questionnaire and via via Visual Analogue Scale (VAS scale). The patient has to indicate her daily functioning from 0 (the balloon had no influence on my daily function) to 10 (because of the balloon I couldn't do anything of my daily work).

    Time frame: 6 days after adhesiolysis

  7. The ease of inserting the intra uterine balloon

    Via questionnaire

    Time frame: once at the time of the surgical procedure (adhesiolysis). This is day 0 of the study

  8. The ease of removing the intra uterine balloon

    Via questionnaire

    Time frame: 6 days after adhesiolysis

06

Study locations

1 site
  • University hospital Ghent
    Ghent, East-Flanders 9000, Belgium
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT03446755
Lead sponsor
University Hospital, Ghent
Responsible party
Sponsor
First posted
Feb 27, 2018
Start date
Jan 17, 2018
Primary completion
Dec 16, 2020
Completion
Dec 16, 2020
Last update
Jul 2, 2021

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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