An observational study in Postoperative Cognitive Dysfunction, sponsored by Milton S. Hershey Medical Center. Completed at 1 site in United States. Open to participants aged 50 Years to 99 Years. Per ClinicalTrials.gov, last updated 2020-07-08.
Sponsored by Milton S. Hershey Medical Center · Observational
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Among 35 studies in Postoperative Cognitive Complications with a site in United States — 6 open to participants now, 7 under way, none of them phase 3. Postoperative Cognitive Complications · United States.
Among the 35 studies in Postoperative Cognitive Complications with a site in United States, this one is the 6th largest by enrollment of the 13 observational ones that give a count, is one of 4 that started in 2018, is one of 13 observational ones, and was the 20th registered.
260 studies on the registry are indexed under Postoperative Cognitive Complications; 55 are open to participants now.
Browse Postoperative Cognitive Complications studies →6 of the 35 studies in Postoperative Cognitive Complications with a site in United States are open now. Recruiting first, the newest first:
University of Pittsburgh · Sites in United States
Ages 65+
University of Rochester · Sites in United States
Ages 60+
Beth Israel Deaconess Medical Center · Sites in United States
Ages 60+ · Healthy volunteers
Columbia University · Sites in United States
Ages 10–26 · Healthy volunteers
University of Texas Southwestern Medical Center · Sites in United States
Ages 18+
A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →
Of the 34 Postoperative Cognitive Complications studies recruiting now, 22 (65%) set no upper age limit and 4 (12%) stop at 75 or younger; 2 take children under 18; 6 take healthy volunteers.
This study: 50 Years to 99 Years · all sexes.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
35 studies; the count open now beside each. This study's row is marked.
First in 2006; this study’s year is marked. 4 started in 2018.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 57 is below the median of 100 across 113 observational studies indexed under Postoperative Cognitive Complications.
Median enrollment 63 across the 22 interventional studies, 41 across the 13 observational. Of the 26 that completed or were terminated, 8 (31%) have results posted.
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2 of 35 have an industry lead sponsor. The 10 most frequent:
Milton S. Hershey Medical Center is the lead sponsor of 492 studies on the registry; 60 are open to participants now.
Of its 58 completed or terminated interventional studies of FDA-regulated products, 46 (79%) have results posted.
Milton S. Hershey Medical Center has 1 study filed under Postoperative Cognitive Complications — fewer than ten, so there is no comparison to draw.
4 of the studies in Postoperative Cognitive Complications with a site in United States that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06133842Beth Israel Deaconess Medical CenterCEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State | 2026-12 |
| NCT07872982Scienceforbrain, UABBrainProtect-guided, Real-time Cerebral Autoregulation Monitoring and Protection of Brain During Cardiac Surgery With Cardiopulmonary Bypass Requiring Heart-lung Machine | 2027-09-30 |
| NCT06042413University of PittsburghPrediction and Prevention of Postoperative Mortality and Morbidity | 2027-10 |
| NCT07217912University of RochesterDaridorexant to Prevent Post-cardiotomy Delirium | 2027-11-01 |
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Among the 35 studies in Postoperative Cognitive Complications with a site in United States, from their registry updates:
This tab as a report to print or save as PDF → With an account.
A longitudinal observational study examining preoperative, intraoperative and postoperative factors associated with Postoperative Cognitive Dysfunction in patients older than the age of 50.
A longitudinal observational study examining factors associated with Postoperative Cognitive Dysfunction (POCD) utilizing a computerized neurocognitive battery. In addition, investigators seek to assess the presence of pre-existing psychiatric disorders and chronic pain to determine their relationship with POCD. The study will seek to compare the rates of POCD in previously published literature with performance on a computerized neurocognitive battery. In addition, the study will seek to determine preoperative, intraoperative and postoperative factors associated with POCD by comparing these variables to performance on a computerized neurocognitive battery.
Adult population over the age of 50 years old undergoing general, neuraxial or regional anesthesia for elective surgery.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
neurocognitive testing, computerized
Also known as: CogState Brief Battery
Change in performance on the CogState Brief Battery
Neurocognitive Test. Detection Task (Score: normal - abnormal), One Card Learning Task (Score: normal - abnormal) One Back Task (Score normal - abnormal) Identification Task (Score normal - Abnormal) Scores are based on normal distributed population data. Scores are measured on a linear scale with no maximum score. Research subjects will also act as their own control based on baseline performance in this longitudinal study.
Time frame: Change from baseline on the Cogstate Brief Battery score at postoperative Day 30-40.
Change in performance on the Beck Clinical Depression Inventory (BDI)
Test for symptoms of clinical depression. (Scored: 1 to \>40 from normal to extreme depression)
Time frame: Change in baseline on the Beck Clinical Depression Inventory at postoperative Day 30-40.
Change in performance on the Short-Form McGill Pain Questionnaire (SF-MPQ-2)
Test of presence of chronic pain (Scored 0-3(severe)) Validates the sensory component of neuropathic or chronic pain, a visual analog scale (Scored: no pain to worst possible pain) and a Present Pain Intensity (Scored: 0-5 (worst)).
Time frame: Change in baseline on the SF-MPQ-2 at postoperative Day 30-40.
Barthel Index of Activities of Daily Living
Scale to assess independent function of patient. Components assessing continence, mobility, transfer skills, grooming, hygiene, feeding, bathing, stairs and dressing. (Scored: 0-2, dependent - completely independent) Total Score 0-20 (fully dependent - fully independent)
Time frame: Change in baseline on the Barthel Index at postoperative Day 30-40.
Plan to share: No
Ran from Apr 2018 to primary completion in Jun 2020, 26 months.
Of 76 non-industry observational studies under Postoperative Cognitive Complications, half reached primary completion within 27 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 65. This study's 26 months is close to that.
Counting every sponsor, half of 76 studies reached it within 27 months; a quarter within 11 and three quarters within 65.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jul 2020. You cannot join it, but the record below documents what was studied.
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Postoperative Cognitive Complications →
Milton S. Hershey Medical Center →