An observational study in Neuro-Degenerative Disease, sponsored by Xuanwu Hospital, Beijing. Completed. Open to participants aged 50 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-02-26.
Sponsored by Xuanwu Hospital, Beijing · Observational
Resting-state functional magnetic resonance imaging (RS-fMRI) has frequently been used to investigate local spontaneous brain activity in Parkinson's disease (PD) in a whole-brain, voxel-wise manner. To quantitatively integrate these studies, we conducted a coordinate-based meta-analysis on 15 studies that used amplitude of low frequency fluctuation (ALFF) and 11 studies that used regional homogeneity (ReHo). All these ALFF and ReHo studies have compared PD patients with healthy controls. We also performed a validation RS-fMRI study of ALFF and ReHo in a frequency-dependent manner for a novel dataset consisting of PD and healthy controls.
Seed-based d Mapping (formerly Signed Differential Mapping, SDM) software (version 5.141 for Windows) (www.sdmproject.com) was used for meta-analysis.
For the validation, fMRI data were acquired on a 3 Tesla Magnetic Resonance scanner (Trio system; Siemens Magnetom scanner, Erlangen, Germany) with gradient-echo echo-plannar imaging sequences. Whole brain fMRI scanning was carried out. All participants were instructed to keep their eyes closed, relax, remain motionless, not think of anything in particular, and not fall asleep. Foam pads were used to minimize head motion.
PD patients were enrolled from the inpatients and the outptients. Healthy controlls were enrolled using advertisement (media and internet)
Exclusion Criteria:
history of head trauma, 2. substance abuse, 3. psychiatric disorder. For healthy controls, additional exclusion criteria included
the entire group underwent MRI scan
Device: MRI scan
All participants underwent the MRI scan
decreased spontaneous brain activity in PD patients
We found a decreased spontaneous brain activity in left putamen in PD patients
Time frame: 06/2015-01/2016
No study locations are listed for this record.
Plan to share: Yes — We've already uploaded all the raw data to a repository of GigaScience, and part of data to the NITRC repository, named as "PD RS-fMRI meta and validation". After the current study publish, we will update the sharing information here.
Supporting information: Study protocol, Sap
This study is completed, as verified in Feb 2018. You cannot join it, but the record below documents what was studied.
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Xuanwu Hospital, Beijing