An interventional study of Vein ligation first and Artery ligation first in Lung Cancer, Surgery and Circulating Tumor Cell, sponsored by West China Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2020-10-12.
Sponsored by West China Hospital · Not applicable, Interventional, and Treatment
The purpose of this study is to assess the impact of the sequence of vessel interruption in lung cancer patients on tumor cell spread and patient survival by using peripheral blood circulating tumor cells.
Circulating tumor cells (CTCs) in the peripheral blood can be a biomarker to predict tumor recurrence and survival. Handling the tumor during a surgery may promote the release of CTCs into the bloodstream. Therefore, in a surgery of cancer, interruption of the vein before ligation of the artery may be justified. This multi-center randomized controlled trial is to assess the impact of the sequence of vessel interruption in lung cancer patients on tumor cell spread and patient survival by using peripheral blood CTCs.
Exclusion Criteria:
During this procedure, patients undergo lobectomy with the pulmonary vein ligated first.
Procedure: Vein ligation first
During this procedure, patients undergo lobectomy with the pulmonary artery ligated first.
Procedure: Artery ligation first
During this procedure, patients undergo lobectomy with the pulmonary vein ligated first.
During this procedure, patients undergo lobectomy with the pulmonary artery ligated first.
The changes of the level of circulating tumor cells in the peripheral blood
The changes of the level of circulating tumor cells in the peripheral blood before cutting the skin and after closing the chest
Time frame: Intraoperative
3-year Progression-Free-Survival
From the date of recruitment until the date of progression of lung cancer assessed up to 36 months
Time frame: From date of the recruitment, assessed up to 36 months
Blood loss
Blood loss during the surgery
Time frame: During the surgery
Operative time
Operative time during the surgery
Time frame: During the surgery
Length of stay
The length of patients staying in hospital from the date of checking in to the date of checking out
Time frame: From date of admission until the date of discharging or date of death from any cause in hospital, whichever came first, assessed up to 30 days
Morbidity
Complications resulting from surgery, such as pneumonia, air leak and arrhythmia.
Time frame: Within 30 days after surgery
Plan to share: No
This study is status unknown, as verified in Oct 2020. You cannot join it, but the record below documents what was studied.
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West China Hospital