An observational study in Obesity, Metabolically Benign, sponsored by Louis Turcanu Emergency Hospital for Children. Completed. Open to participants aged 5 Years to 18 Years. Per ClinicalTrials.gov, last updated 2018-02-19.
Sponsored by Louis Turcanu Emergency Hospital for Children · Observational
The prevalence of metabolic syndrome (MetS) in young population continues to rise. Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to determine whether these adipokines are significant markers in defining MetS in pediatric population and to assess the effect of hypocaloric diet and physical activity on serum concentrations of adiponectine, leptin, and high sensitivity CRP (hs-CRP).
The idea that adipose tissue is just a form of energy storage has changed dramatically in recent years. Currently, adipose tissue is considered to be a true endocrine gland that fulfills multiple roles in regulating different biological functions. Communication between adipose tissue and the rest of the systems is accomplished through bioactive mediators (adipokines) Adipokines control energy homeostasis and are involved in metabolic, endocrine and immunological processes.The prevalence of metabolic syndrome (MetS) in young population continues to rise. Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to determine whether these adipokines are significant markers in defining MetS in pediatric population and to assess the effect of hypocaloric diet and physical activity on serum concentrations of adiponectine, leptin, and high sensitivity CRP (hs-CRP).
The investigators tested the hypothesis that long-term lifestyle changes and moderate weight loss would reduce the plasma concentrations of adipokines involved in inflammation, angiogenesis, and chemotaxis and would increase adiponectin concentrations.
Material and methods:
A prospective study was conducted over a period of 1 year, between January 2016 and December 2016, on 66 cases of obesity in children diagnosed at the Louis Ţurcanu Emergency Hospital for Children Timisoara. The patients diagnosed with MetS were put on diet and physical exercise for 3 months.
27 studies on the registry are indexed under Obesity, Metabolically Benign; 8 are open to participants now.
This study's enrollment of 66 is below the median of 134 across 10 observational studies indexed under Obesity, Metabolically Benign.
Browse Obesity, Metabolically Benign studies →This is the only study on the registry with Louis Turcanu Emergency Hospital for Children as lead sponsor.
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All children admitted to the Endocrinology, Diabetology and Cardiology Department who met the Inclusion Criteria
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Obese group with metabolic syndrome/Data processing from Patient Medical Files
Behavioral: MetS+
Obese group without metabolic syndrome/Data processing from Patient Medical Files
Other: MetS-
Data processing from Patient Medical Files
Defining obesity in the pediatric population
Measuring weight in kilograms and height in meters in order to calculate BMI and represent it on the percentile graph.
Time frame: Weight and height were measured on day 1 of admission. Obesity was defined as a BMI > the 95th percentile.
Leptin changes in the obese children with metabolic syndrome
Evaluating leptin in the obese group with metabolic syndrome after three months of diet and physical activity.
Time frame: Leptin levels were measured on day 1 of admission and after three months. Normal range was considered < 24ng/ml.
Adiponectin changes in the obese children with metabolic syndrome
Evaluating adiponectin in the obese group with metabolic syndrome after three months of diet and physical activity.
Time frame: Adiponectin levels were measured on day 1 of admittance and after three months in children aged between 4 and 18 years. Levels 4-26 mcg/ml were defined as normal values.
hsCRP changes in the obese children with metabolic syndrome
Evaluating hsCRP in the obese group with metabolic syndrome after three months of diet and physical activity.
Time frame: hsCRP levels were measured on day 1 of admittance and after three months in children aged between 4 and 18 years. Normal levels were considered between 0.1-2.8 mg/l.
No study locations are listed for this record.
Plan to share: No
Ran from Jan 2016 to primary completion in Dec 2016, 11 months.
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This study is completed, as verified in Feb 2018. You cannot join it, but the record below documents what was studied.
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