An observational study in Hyperthyroidism, Thyroidectomy and PTH, sponsored by Bo Wang,MD. Status unknown at 1 site in China. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2018-09-18.
Sponsored by Bo Wang,MD · Observational
The half-life of the parathyroid hormone is about 4min, blood pth test is use in operation to confirm that parathyroid tumor is removed. but the blood pth test is time consuming and unpractical in most of hospital. this study will compare the application of rapid PTH test paper in operation of hyperparathyroidism.PTH test were measured in operation in different way. it will test at the time of preoperation, 15 minutes after surgery, 1 hour after surgery and 24 hours after surgery. thus evaluate the reliability and accuracy of PTH test paper in evaluating the Miami principles with the linear relation of blood PTH and the PTH test paper method.
Primary hyperparathyroidism is a clinically common disease. At present, the gold standard for determining whether the operation is successful is based on the Miami principle. That means The PTH hormone decreased to 30% of the baseline level after 15min after the tumor was removed. However, due to the differences in PTH monitoring conditions in various hospitals, many hospitals cannot perform rapid PTH monitoring in the operation. Therefore many doctors choose rapid freezing pathology to confirm the lesion., This also led to the inability to evaluate PTH in the presence of multiple lesions,and resulting in the need for reoperations.
112 studies on the registry are indexed under Hyperthyroidism; 27 are open to participants now.
This study's planned enrollment of 90 is close to the median of 98 across 48 observational studies indexed under Hyperthyroidism.
Browse Hyperthyroidism studies →Bo Wang,MD is the lead sponsor of 5 studies on the registry; 1 is open to participants now.
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We use the characteristics of short half-life of the parathyroid hormone and try to evaluate it by PTH strip semi-quantitative method. PTH, blood calcium and PTH test were measured at pre-operation, 15 minutes after surgery, 1 hour after surgery and 24 hours after surgery. To evaluate the reliability and accuracy of PTH strip in evaluating the Miami principles with the linear relation of blood PTH and the test paper method.
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Exclusion Criteria:
Patients diagnosed with primary hyperparathyroidism are prepared for parathyroid surgery. PTH test paper is used addtional at the time point according to Miami principle
Patients diagnosed with Secondary hyperthyroidism are prepared for parathyroid surgery. PTH test paper is used addtional at the time point according to Miami principle
Patients diagnosed with unilateral thyroid benign tumor were prepared for unilateral thyroidectomy. PTH test paper is used addtional at postoperation
Patients diagnosed with bilateral thyroid carcinoma were prepared to undergo total thyroidectomy and bilateral central clearing.PTH test paper is used addtional at postoperation
Serum PTH
Routine serum PTH test, using immunoluminescence.
Time frame: 0 minutes, 15 minutes, 1 hour and 24 hours post operation
Serum calcium
Routine serum electrolyte detection.
Time frame: 0 minutes, 15 minutes, 1 hour and 24 hours post operation
PTH test paper
PTH test paper test for blood
Time frame: 0 minutes, 15 minutes, 1 hour and 24 hours post operation
Plan to share: Undecided
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This study is status unknown, as verified in Sep 2018. You cannot join it, but the record below documents what was studied.
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Bo Wang,MD