An observational study in Intracranial Aneurysms and Ruptured Aneurysm, sponsored by Fondation Ophtalmologique Adolphe de Rothschild. Active, not recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-01-20.
Sponsored by Fondation Ophtalmologique Adolphe de Rothschild · Observational
Sub arachnoid hemorrhage consecutive to intracranial aneurysm rupture is a devastating disease. Predictors of intracranial aneurysm rupture are limited and focus mainly on size and location. Platelet activation may have a deleterious role on aneurysm rupture. The assumption is that patients with ruptured intracranial aneurysm will present a higher rate of platelet activation compared to patients with non ruptured aneurysms.
Adult patients presenting a single or multiple intracranial aneurysm for which an intervention is planned (endovascular treatment or surgery)
Exclusion Criteria:
In case of an endovascular treatment : * A blood sample (venous or arterial) of 10 ml will be taken at the beginning of the procedure, an intra aneurysmal blood sample (1mL) will be taken during the procedure and a blood sample (arterial) of 1 mL will be taken at the end of the procedure. * Iterative blood samples (arterial) of 10 mL will be taken at each follow up visit. In case of a surgery treatment : * A blood sample (venous or arterial) of 10 ml will be taken at the beginning of the surgery. * A Tissue sample will be taken during the surgery * Iterative blood samples (arterial) of 10 mL will be taken at each follow up visit.
Proportion of patients with platelet activation
comparison of this proportion between patients with ruptured versus non ruptured intracranial aneurysm
Time frame: in the 7 days before embolisation
This study is active, not recruiting, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Fondation Ophtalmologique Adolphe de Rothschild