An interventional study of Noninvasive mechanical ventilation in Hypercapnic Respiratory Failure, sponsored by Dokuz Eylul University. Completed at 1 site in Turkey. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2018-01-12.
Sponsored by Dokuz Eylul University · Not applicable, Interventional, and Treatment
The aim of the present study; To compare the effects of respiratory support options available for NIMV at the emergency department; i.e. AVAPS and ST/T modes, on the patient's pCO2 values, additional treatment need (another non-invasive ventilation method or endotracheal intubation) and the duration of stay in hospital.
Non-invasive positive pressure ventilation (NIMV) is a life-saving procedure for patients with hypoxic and/or hypercapnic respiratory failure. AVAPS (average volume assured pressure support) is a noninvasive ventilation mode which has been developed to assure volume and pressure controlled respiratory support. AVAPS can ensure a constant tidal air volume to the patient with variable pressure support. Thus the positive features of the volume and pressure controlled support, which have a positive impact on the healing and recovery processes are combined.
This study aims to compare, in a randomized order, BPAP ST/T and BPAP ST / T Mode with AVAPS, in patients with hypercapnic respiratory failure in the emergency department.
Subjects: One hundred and two patients with hypercapnic respiratory failure will be included.
Primary outcome; decrease in the PaCO2 values
Secondary outcomes are stated as; Failure of treatment options, or change of the NIMV mode due to patient noncompliance or the patient's need for intubation and length of hospital stay (length of stay in the hospital from the emergency department).
1,369 studies on the registry are indexed under Respiratory Insufficiency; 264 are open to participants now.
This study's enrollment of 80 is above the median of 60 across 860 interventional studies indexed under Respiratory Insufficiency.
Browse Respiratory Insufficiency studies →Dokuz Eylul University is the lead sponsor of 261 studies on the registry; 35 are open to participants now.
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PaCO2 > 45mmHg and any of the following
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Relapsed: the illness came back after treatment had worked. Refractory: it did not respond to treatment, or stopped responding while still on it.
Relapsed and refractory
Relapsed: the illness came back after treatment had worked. Refractory: it did not respond to treatment, or stopped responding while still on it.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Non-invasive Ventilation with BPAP ST/T mode
Device: Noninvasive mechanical ventilation
Non-invasive Ventilation with AVAPS mode
Device: Noninvasive mechanical ventilation
PaCO2 values
Will measure change in PaCO2 values in the blood gase analysis of patients comparing those treated with BPAP ST/T and those with AVAPS
Time frame: On arrival, at one hour, and at two hourly intervals thereafter
Failure of treatment options
Change of the NIMV mode due to patient noncompliance (switching to the second mode) or the patient's need for intubation during the treatment
Time frame: During the treatment
Length of hospital stay
Length of hospital stay in the hospital (From the emergency department admission)
Time frame: up to 6 months
The time of treatment
The sum of the noninvasive ventilation time in the emergency department.
Time frame: During the treatment
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Jan 2018. You cannot join it, but the record below documents what was studied.
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