An interventional study of Standardized meal test in Morbid Obesity, sponsored by Rijnstate Hospital. Completed. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-12-27.
Sponsored by Rijnstate Hospital · Not applicable, Interventional, and Basic science
Obesity is an increasing world wide problem. Moreover, the increase in patients who are considered morbidly obese is even higher (Sturm et al, Healt Aff 2004). Conservative approaches such as diets or medication are unsuccessful in the majority of the patients. Additionally, (morbid) obesity leads often to cardiovascular diseases, such as hypertension, dyslipidemia and type 2 diabetes (T2DM). When patients need insulin to regulate their glucose levels, their weight is even more difficult to control. Therefore, bariatric procedures are increasingly performed, with over 8.000 procedures in the Netherlands in 2013. The two most performed types of bariatric surgery in the Netherlands are the Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) and the Laparoscopic Sleeve Gastrectomy (LSG). Within the LRYGB there are different variants available. In a recently initiated randomized controlled trial (RCT) from our centre, a comparison between two variants of RYGB was performed. In this RCT our standard RYGB (s-RYGB:alimentary limb (AL) of 150cm; biliopancreatic limb (BPL) of 75cm) was compared with a RYGB with an long BPL (LBPLRYGB:AL of 75cm and a BPL of 150cm). A LBPLRYGB might improve weight loss and reduction after surgery. The exact mechanism of action is still not fully understood. Stomach volume is decreased and satiety levels often increase, probably due to changes in incretin levels. Passage of foods through the gastrointestinal tract are altered after RYGB. A possible explanation might be found in different levels of incretins (such as GLP-1, PYY and ghrelin) and bile acids (FGF-19 and FGF-21) after bariatric surgery.
Exclusion Criteria:
Other: Standardized meal test
Other: Standardized meal test
Preoperatively and postoperatively standardized meal test
Change from baseline incretine levels during a standardized meal test four weeks after surgery.
Time frame: Preoperatively and four weeks after surgery
Change from baseline gut hormone levels during a standardized meal test four weeks after surgery.
Time frame: Preoperatively and four weeks after surgery
Change from baseline bile acid levels during a standardized meal test four weeks after surgery.
Time frame: Preoperatively and four weeks after surgery
No study locations are listed for this record.
Plan to share: No
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Rijnstate Hospital