An observational study in CRS, sponsored by Hillel Yaffe Medical Center. Completed. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-12-20.
Sponsored by Hillel Yaffe Medical Center · Observational
Professor Hossam Haick from the Technion, developed an electronic nose for diagnosis of diseases via breath samples.
Biomarkers from nose and sinuses and upper respiratory tract can be detected by "electronic nose".
Identification of biomarkers from nose and sinuses and upper respiratory tract can differentiate between the subtypes of CRS (Chronic rhinosinusitis) and may serve as markers for disease (vs controls), of disease activity (predicting aggressive disease course, predicting Malignant vs Benign nasal "polyps", as inverted papillpma or carcinoma; predicting response to therapy (Steroid , Antibiotics, Nasal wash, Surgery).
Professor Hossam Haick from the Technion, developed an electronic nose for diagnosis of diseases via breath samples.
Biomarkers from nose and sinuses and upper respiratory tract can be detected by "electronic nose".
Identification of biomarkers from nose and sinuses and upper respiratory tract can differentiate between the subtypes of CRS (Chronic rhinosinusitis) and may serve as markers for disease (vs controls), of disease activity (predicting aggressive disease course, predicting Malignant vs Benign nasal "polyps", as inverted papillpma or carcinoma; predicting response to therapy (Steroid , Antibiotics, Nasal wash, Surgery).
The aim of this study is to evaluate various CRS diseases with the Electronic Nose trying to better differentiate CRSwPolyps , CRS without Polyps, PCD, AFS, Vasculitis (as Wegener Granulomatosis) and Allergic Rhinitis with CRS.
For that reason samples were taken from patients from different groups of "CRS patients": 1. CRSwPolyps with no Eosonophilia , 2. CRSwPolyps with Eosonopholia, 3. CRS without Polyps, 4. PCD, 5. AFS, 6. allergic rhinitis and 7. Control subjects.
236 studies on the registry are indexed under Nasal Polyps; 68 are open to participants now.
This study's enrollment of 71 is below the median of 100 across 47 observational studies indexed under Nasal Polyps.
Browse Nasal Polyps studies →Hillel Yaffe Medical Center is the lead sponsor of 305 studies on the registry; 10 are open to participants now.
Counted across the registry records on this site, refreshed daily.
CRS patients will be recruited through the Rhinologic clinic at the Hillel Yaffe Medical Center, after signing an informed consent. Healthy individuals that meet the inclusion/ exclusion criterions will be recruited from among the patient's escorts to the clinic or patients coming for other surgeries (unrelated spouse or acquaintance after signing an informed consent.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Control subjects:
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
The human immunodeficiency virus, which weakens the immune system.
Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
HIV
The human immunodeficiency virus, which weakens the immune system.
Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
CRS patients with nasal polyposis, and no eosonophilia.
CRS patients with nasal polyposis and eosonophilia.
Patients with chronic rhinosinusitis and no nasalpolyposis.
Patients with Primrary ciliary dyskinesia .
Patients with allergic fungal rhinosinusitis.
Patients with allergic rhinitis
Healthy subjects.
discrimination between healthy and CRS subtypes based on SNOT 22 questionnaire results
SNOT 22 score (score 0-110)
Time frame: change in score from recruitment and every six month until 3 years after recruitment.
Successful discrimination between healthy and CRS subtypes based on sensor response (electrical resistance measurements)
Electrical resistance-Disease diagnosis based on breath analysis data classification using an artificial olfactory system (AKA, Electronic nose)
Time frame: Change of electrical resistance from recruitment and every six month until 3 years after recruitment.
No study locations are listed for this record.
Plan to share: Undecided
No publications or documents are linked to this record.
Ran from Sep 2014 to primary completion in Sep 2016, 23 months.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Dec 2017. You cannot join it, but the record below documents what was studied.
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