ClinicalTrials.gg
WithdrawnNCT03374605Updated Aug 7, 2018

Modulating Context Generalization Through Transcranial Direct Current Stimulation

An interventional study of active tDCS and sham tDCS in Anxiety and Fear, sponsored by Butler Hospital. Withdrawn at 1 site in United States. Open to participants aged 18 Years to 55 Years. Per ClinicalTrials.gov, last updated 2018-08-07.

Sponsored by Butler Hospital · Not applicable, Interventional, and Basic science

Why this study was withdrawn
This small mechanistic pilot study was ended prior to first enrollment after considering factors related to feasibility (e.g., available time and resources).

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Phase
Not applicable
Study type
Interventional
Enrollment
0
Allocation
Randomized
Ages
18 Years to 55 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-13

Among 2,269 studies in Anxiety Disorders with a site in United States — 398 open to participants now, 503 under way, 13 of them phase 3. Anxiety Disorders · United States.

Enrollment
1,985th of 2,045
0 · median 68
Started
2018
with 119 others
No phase
1,609 of 2,269
295 open now
Registered
854th of 2,269
by date

Among the 2,269 studies in Anxiety Disorders with a site in United States, this one is the 1,985th largest by enrollment of the 2,045 interventional ones that give a count, is one of 120 that started in 2018, is one of 1,609 with no phase, and was the 854th registered.

Anxiety Disorders

7,207 studies on the registry are indexed under Anxiety Disorders; 1,682 are open to participants now.

Browse Anxiety Disorders studies →

Open to participants now

398 of the 2,269 studies in Anxiety Disorders with a site in United States are open now. Recruiting first, the newest first:

393 more — sign in →

All 398 open studies →

A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →

Who these studies take

Of the 944 Anxiety Disorders studies recruiting now, 417 (44%) set no upper age limit and 460 (49%) stop at 75 or younger; 233 take children under 18; 317 take healthy volunteers.

This study: 18 Years to 55 Years · all sexes · no healthy volunteers.

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02

Study summary

Behavioral adaptation is particularly relevant to anxiety and related disorders, where exposure-based therapies rely on such adaptation as part of behavior therapy.. However, while initial fear reactions generalize easily across contexts, subsequent adaption of behavior through learning is context-specific. The primary goal of this study is to investigate whether transcranial direct current stimulation (tDCS) can be used to acutely impact generalization of subsequent learning across contexts in an experimental paradigm. As part of this study, participants will complete a clinical interview and questionnaires, as well as a computer task asking them to make choices between stimuli on the screen and during which they may or may not receive tDCS.

03

Conditions studied

  • Anxiety and Fear

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04

Who can participate

Ages eligible
18 Years to 55 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Primary diagnosis of an anxiety or related disorder, (defined as panic disorder, social anxiety disorder, generalized anxiety disorder, obsessive-compulsive disorder, and/or post-traumatic stress disorder);
  2. aged 18-55;
  3. ability to speak, read, write, and understand English sufficiently well to complete study procedures and provide ;
  4. Stable psychiatric medication use for at least 6 weeks.

Exclusion criteria

Exclusion Criteria:

  1. Lifetime history of psychotic symptoms or bipolar disorder,
  2. Current substance use disorder;
  3. Acute suicidality or homicidality,
  4. Significant neurological disorder,
  5. Any problems that would interfere with study participation, significant or unstable medical disorders and tDCS-related (e.g., implanted metallic substances, pregnancy, holes in the skull, skin abnormalities under stimulation sites).
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
0 participants (actual)

Study arms

  • Experimental
    Active tDCS

    Device: active tDCS

  • Sham comparator
    Sham tDCS

    Device: sham tDCS

Interventions

  • Deviceactive tDCS

    15 minutes of active (2mA) high definition tDCS will be applied to the participant's skull. The anodal electrode will be placed over 10-20 EEG coordinate AF7 and cathodal electrode over coordinate Fz.

  • Devicesham tDCS

    15 minutes of sham high definition tDCS will be applied to the participant's skull. The anodal electrode will be placed over 10-20 EEG coordinate AF7 and cathodal electrode over coordinate Fz.

06

What researchers measure

Primary outcomes

  1. Relative frequency of selection of task-specific stimuli

    Time frame: 1 hour (measurement occurs 1 time only)

07

Study locations

1 site
  • Butler Hospital
    Providence, Rhode Island 02906, United States
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Start is estimated for Feb 2018; primary completion for Dec 2019, 22 months later.

How these figures are worked out, and which studies are left out of them.

Registered
Dec 12, 2017
First posted
Dec 15, 2017
StartEst.
Feb 2018
Primary completionEst.
Dec 2019
CompletionEst.
Dec 2019
Last update
Aug 7, 2018
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 7, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03374605
Lead sponsor
Butler Hospital
Responsible party
Sponsor
First posted
Dec 15, 2017
Start date
Feb 2018 (estimated)
Primary completion
Dec 2019 (estimated)
Completion
Dec 2019 (estimated)
Last update
Aug 7, 2018

Study contacts

Sarah Garnaat, PhD
principal investigator · Butler Hospital

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Aug 2018. You cannot join it, but the record below documents what was studied.

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Discussion

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