An interventional study of Yoga-Based Intervention and group CBT in Depression in Adolescence, sponsored by Butler Hospital. Recruiting at 2 sites in United States. Open to participants aged 12 Years to 18 Years. Per ClinicalTrials.gov, last updated 2026-10-26.
Sponsored by Butler Hospital · Not applicable, Interventional, and Other
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Among 25 studies in Depression by Butler Hospital — 1 open to participants now, 2 under way, none of them phase 3. Depression · Butler Hospital.
Among the 25 studies in Depression by Butler Hospital, this one is the 11th largest by planned enrollment of the 24 interventional ones that give a count, is the only one that started in 2026, is one of 14 with no phase, and was the 25th registered.
8,590 studies on the registry are indexed under Depression; 1,728 are open to participants now.
Browse Depression studies →1 of the 25 studies in Depression by Butler Hospital is open now, in 1 country.
By country, each count listing its studies:
Of the 1,090 Depression studies recruiting now, 470 (43%) set no upper age limit and 520 (48%) stop at 75 or younger; 203 take children under 18; 311 take healthy volunteers.
This study: 12 Years to 18 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
25 studies; the count open now beside each. This study's row is marked.
First in 1999; this study’s year is marked. 1 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 96 is above the median of 81 across 7,074 interventional studies indexed under Depression.
Median enrollment 62 across the 24 interventional studies, 40 across the 1 observational. Of the 22 that completed or were terminated, 6 (27%) have results posted.
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Butler Hospital is the lead sponsor of 119 studies on the registry; 14 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 4 (80%) have results posted.
None of the studies under way reaches primary completion within a year.
Among the 25 studies in Depression by Butler Hospital, from their registry updates:
This tab as a report to print or save as PDF → With an account.
In this study, we will conduct a pilot RCT of a yoga-based intervention (YBI) vs. group cognitive-behavioral therapy (gCBT) at two sites. We will recruit 48 adolescent participants each in Columbus, OH and Boston, MA (96 total). We have a priori targets for indices of feasibility and acceptability, including recruitment rate, retention for assessments, class attendance, interventionist fidelity to manuals, and participant satisfaction. We hypothesize that we will meet these metrics at both sites.
In this study, we will conduct a pilot RCT of a yoga-based intervention (YBI) vs. group cognitive-behavioral therapy (gCBT) at two sites. We will recruit 48 adolescent participants each in Columbus, OH and Boston, MA (96 total). We have a priori targets for indices of feasibility and acceptability, including recruitment rate, retention for assessments, class attendance, interventionist fidelity to manuals, and participant satisfaction. We hypothesize that we will meet these metrics at both sites. We will examine preliminary outcomes of depression, functional impairment, and anxiety, as well as engagement of hypothesized mechanisms of self-compassion, and metacognitive awareness. Participants will be adolescents with depression who will receive their assigned intervention for 3 months and be followed for 3 additional months. Parents will also be invited to participate in assessments regarding their child. Adolescent participants will be comprised of Set A (n=72) vs. Set B (where Set B participants do not meet Set A criteria for severity of depression symptoms or stability of other depression treatment. For both sets, in-person CBT groups and the yoga intervention will occur on the campus of the study hospital site. Randomization will be stratified by site and by set (A/B). Masked evaluators will assess depression symptom severity, which will be the primary outcome in a future fully-powered effectiveness trial.
Set A Inclusion Criteria. In order to be eligible to participate in this study, an individual must meet all of the following criteria:
Set A Exclusion criteria: Adolescents will be excluded if they:
Set B Eligibility criteria
Participants who are not eligible for Set A may be enrolled in Phase 2 Set B, such that they will be eligible to attend classes but their data will not be considered in our main analyses.
Set B Inclusion Criteria. In order to be eligible to participate in this study, an individual must meet all of the following criteria:
Set B Exclusion criteria: Adolescents will be excluded if they:
Yoga-based intervention
Behavioral: Yoga-Based Intervention
group CBT
Behavioral: group CBT
This intervention consists of twice-weekly yoga classes. Classes will be led by trained yoga teachers. Each week for 12 weeks, classes will occur once in person (55 mins) and once virtually (30 mins).
This intervention consists of twice-weekly group CBT sessions. Sessions will be led by trained behavioral health specialists. Each week for 12 weeks, sessions will occur once in person (55 mins) and once virtually (30 mins).
Credibility
Assessed by Credibility scale of Credibility Expectancy Questionnaire
Time frame: Start of treatment
Expectancy
Assessed by Expectancy scale of Credibility Expectancy Questionnaire
Time frame: Start of treatment
Program Satisfaction
Assessed by the Client Satisfaction Questionnaire (CSQ-8)
Time frame: 12 weeks
Class Attendance
Assessed via staff observation
Time frame: Week 0-12
Plan to share: Yes — De-identified data reflecting demographics, primary, and secondary outcomes.
No publications or documents are linked to this record.
Started Jul 2026 (actual). Primary completion is estimated for Dec 2027, 17 months after the start.
Of 3,476 non-industry interventional studies with no phase under Depression, half reached primary completion within 21 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 41. This study's planned 17 months is below that.
Counting every sponsor, half of 3,574 studies reached it within 21 months; a quarter within 9 and three quarters within 41.
Start moved once since we started tracking on Sep 25, 2026: Jun 2026 → Jul 2026, on Oct 2, 2026.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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