ClinicalTrials.gg
CompletedNCT03370783Updated Jul 20, 2022

Acute Neuroimmune Effects of Alcohol Using Free Water Imaging

An interventional study of Ethanol in Alcohol Drinking, sponsored by Brown University. Completed at 1 site in United States. Open to participants aged 21 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-07-20.

Sponsored by Brown University · Not applicable, Interventional, and Other

From the registry’s dates

  • Registered 8 months after the study started (first participant enrolled Mar 2017, registered Dec 2017).
Phase
Not applicable
Study type
Interventional
Enrollment
25
Allocation
Not applicable
Ages
21 Years to 45 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 23 studies testing ethanol in Alcohol Drinking — 3 open to participants now, 5 under way, 1 of them phase 3. Ethanol · Alcohol Drinking.

Enrollment
15th of 23
25 · median 37
Started
2017
with 1 other
No phase
9 of 23
1 open now
Registered
11th of 23
by date
Lead sponsor
3 of 23
Brown University

Among the 23 studies testing ethanol in Alcohol Drinking, this one is the 15th largest by enrollment, is one of 2 that started in 2017, is one of 9 with no phase, and was the 11th registered.

By phase

23 studies; the count open now beside each. This study's row is marked.

No phasethis study9 · 1 open
Phase 19 · 1 open
Phase 23 · 1 open
Phase 2/31 · 0 open
Phase 41 · 0 open

By the year they started

First in 2003; this study’s year is marked. 2 started in 2017.

Size and results

Median enrollment 37 across the 23 interventional studies. Of the 17 that completed or were terminated, 7 (41%) have results posted.

Watch this landscapeDownload CSVWith an account: a weekly mail of what changed among 23 studies testing ethanol in Alcohol Drinking, or all of them as a file.
02

Study summary

This study examines the effects of moderate alcohol intake on the brain, the immune system, and cognition.

Read the detailed description

The study involves a within-subjects, pre/post design to assess the effects of a moderate dose of alcohol on immune biomarkers, neurobiological measures, and cognitive functioning. The study recruits healthy adults (ages 21-45) from the community to complete the experimental protocol. Participants complete magnetic resonance imaging scans, blood sample collection, and cognitive testing in the context of alcohol consumption.

03

Conditions studied

  • Alcohol Drinking

Browse trials for

04

Who can participate

Ages eligible
21 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Ages 21-45 years
  • Able to speak and read English at least at 8th grade level
  • Moderate self-reported alcohol use in the past year
  • in normal to overweight range
  • Right-handed

Exclusion criteria

Exclusion Criteria:

  • History of heavy drinking
  • Currently seeking alcohol or drug treatment
  • Chronic disease requiring use of medication
  • Recent antibiotic or probiotic use
  • Chronic daily use of NSAIDs
  • Chronic GI disorder
  • Use of illicit drugs
  • Major psychiatric disorder or suicidality
  • Fainting, weakness, infection, excessive bruising, or distress resulting from standard blood draw
  • Safety for MRI scan
  • Inability to abstain from use of tobacco products prior to or during study
  • Inability to abstain from use of cannabis prior to or during study
  • Pregnant, nursing, or may become pregnant
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

BMI (body mass index)

Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.

What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Not applicable
Intervention model
Single group
Masking
Single (Participant)
Enrollment
25 participants (actual)

Interventions

  • Moderate alcohol consumption

06

What researchers measure

Primary outcomes

  1. Immune biomarkers

    Time frame: 1-3 hours after alcohol intake

07

Study locations

1 site
  • Brown University
    Providence, Rhode Island 02912, United States
08

References and documents

Study documents

PDFs hosted by the registry, ClinicalTrials.gov.

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 20, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03370783
Lead sponsor
Brown University
Responsible party
Mollie Monnig (Assistant Professor of Behavioral and Social Sciences, Brown University) — Principal investigator
First posted
Dec 12, 2017
Start date
Mar 31, 2017
Primary completion
Sep 28, 2017
Completion
Sep 28, 2017
Last update
Jul 20, 2022

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2022. You cannot join it, but the record below documents what was studied.

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Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

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Studies of the drug tested here: Ethanol

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