An observational study in Obesity, sponsored by Imperial College London. Completed at 1 site in Ireland. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-08-08.
Sponsored by Imperial College London · Observational
Among 36 studies in Obesity by Imperial College London — 5 open to participants now, 6 under way, none of them phase 3. Obesity · Imperial College London.
Among the 36 studies in Obesity by Imperial College London, this one is one of 3 that started in 2017, is one of 9 observational ones, and was the 22nd registered.
11,522 studies on the registry are indexed under Obesity; 2,033 are open to participants now.
Browse Obesity studies →5 of the 36 studies in Obesity by Imperial College London are open now, in 2 countries. Recruiting first, the newest first:
Imperial College London · Sites in United Kingdom
Imperial College London · Sites in Ireland
Imperial College London · Sites in United Kingdom
Imperial College London · Sites in United Kingdom
Imperial College London · Sites in United Kingdom
By country, each count listing its studies:
Of the 1,336 Obesity studies recruiting now, 377 (28%) set no upper age limit and 856 (64%) stop at 75 or younger; 168 take children under 18; 491 take healthy volunteers.
This study: 18 Years and older · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
36 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 6 · Phase 2 1
First in 2008; this study’s year is marked. 3 started in 2017.
This study's enrollment of 34 is below the median of 114 across 2,154 observational studies indexed under Obesity.
Median enrollment 53 across the 27 interventional studies, 100 across the 9 observational. Of the 25 that completed or were terminated, 19 (76%) have results posted.
This tab as a report to print or save as PDF → With an account.
Imperial College London is the lead sponsor of 843 studies on the registry; 180 are open to participants now.
Of its 9 completed or terminated interventional studies of FDA-regulated products, 6 (67%) have results posted.
1 of the studies in Obesity by Imperial College London that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT04432025Imperial College LondonMedication Following Bariatric Surgery for Type 2 Diabetes Mellitus | 2027-04-01 |
Among the 36 studies in Obesity by Imperial College London, from their registry updates:
Nothing recorded among them since 2026-09-25.
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Roux-en-Y gastric bypass (RYGB) decreases appetite, caloric intake, glycemia, and body weight, all of which are maintained long term.It is controversial whether, after RYGB, patients choose to eat less high fat and sugary foods in favor of lower energy dense alternatives. Therefore the proposition to use direct measures in humans after RYGB to test the hypothesis that the selection and intake of foods varying in fat content and glycemic index, as well as the pattern of ingestion within and across meals, changes in a manner that leads to beneficial outcomes on body weight.
Roux-en-Y gastric bypass (RYGB) decreases appetite, caloric intake, glycemia, and body weight, all of which are maintained long term.It is controversial whether, after RYGB, patients choose to eat less high fat and sugary foods in favor of lower energy dense alternatives. If true, this could conceivably contribute to improved glycemia and body weight. Disparities among studies on food selection and intake are likely due to the almost complete reliance on self-reported food intake which is vulnerable to inaccuracy.This controversy can best be resolved by complementing existing findings with direct measures of target behaviour in humans. Therefore the proposition to use direct measures in humans after RYGB to test the hypothesis that the selection and intake of foods varying in fat content and glycemic index, as well as the pattern of ingestion within and across meals, changes in a manner that leads to beneficial outcomes on body weight.
Patients with obesity attending a specialist obesity clinic and free living individuals.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Surgical and non-surgical groups:
A) Bariatric surgery B) Controls with no history of bariatric surgery
Exclusion Criteria:
Systemic or gastrointestinal condition which may affect food intake or preference, including:
i) pregnancy or ii) breast feeding.
Obese patients due to undergo gastric bypass surgery
Behavioral: Food Preference
Healthy free-living individuals
Behavioral: Food Preference
Buffet meal to assess food preference
Total Food Intake (Lunch Buffet) at 24 Months
Determine the effect of RYGB on total food intake from an ad libitum lunch buffet
Time frame: 24 months
Change in Absolute Intake of Fat
Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of fat from an ad libitum lunch buffet
Time frame: 24 months
Change in Absolute Intake of Carbohydrates
Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of carbohydrates from an ad libitum lunch buffet
Time frame: 24 months
Change in Absolute Intake of Sugar
Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of sugar from an ad libitum lunch buffet
Time frame: 24 months
Change in Absolute Intake of Protein
Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of protein from an ad libitum lunch buffet
Time frame: 24 months
| Milestone | Gastric Bypass | Healthy Free-living Individuals |
|---|---|---|
| Started | 14 | 20 |
| Completed | 14 | 20 |
| Not completed | 0 | 0 |
Determine the effect of RYGB on total food intake from an ad libitum lunch buffet
| kJ | Gastric Bypass | Healthy Free-living Individuals |
|---|---|---|
| Total Food Intake (Lunch Buffet) at 24 Months | 2540.1 ± 431.0 | 721 ± 201 |
Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of fat from an ad libitum lunch buffet
| kJ | Gastric Bypass | Healthy Free-living Individuals |
|---|---|---|
| Change in Absolute Intake of Fat | -1549.7 ± 298.9 | 301 ± 70.1 |
Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of carbohydrates from an ad libitum lunch buffet
| kJ | Gastric Bypass | Healthy Free-living Individuals |
|---|---|---|
| Change in Absolute Intake of Carbohydrates | -2088.6 ± 370.1 | 280 ± 40.3 |
Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of sugar from an ad libitum lunch buffet
| kJ | Gastric Bypass | Healthy Free-living Individuals |
|---|---|---|
| Change in Absolute Intake of Sugar | -890.7 ± 258.1 | 160.0 ± 39.8 |
Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of protein from an ad libitum lunch buffet
| kJ | Gastric Bypass | Healthy Free-living Individuals |
|---|---|---|
| Change in Absolute Intake of Protein | -360.7 ± 91.4 | 140.2 ± 35.2 |
Collected over 24 months. Non-serious events are listed at a 0% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Gastric Bypass | 0/14 (0%) | 0/14 (0%) | 0/14 (0%) |
| Healthy Free-living Individuals | 0/20 (0%) | 0/20 (0%) | 0/20 (0%) |
| Age, Continuous(years) | Gastric Bypass | Healthy Free-living Individuals | Total |
|---|---|---|---|
| Mean | 51.0 ± 7.8 | 28 ± 4.1 | 39.5 ± 5.95 |
| Sex: Female, Male(Participants) | Gastric Bypass | Healthy Free-living Individuals | Total |
|---|---|---|---|
| Female | 10 | 12 | 22 |
| Male | 4 | 8 | 12 |
| Ethnicity (NIH/OMB)(Participants) | Gastric Bypass | Healthy Free-living Individuals | Total |
|---|---|---|---|
| Hispanic or Latino | 0 | 0 | 0 |
| Not Hispanic or Latino | 14 | 20 | 34 |
| Unknown or Not Reported | 0 | 0 | 0 |
| Region of Enrollment(participants) | Gastric Bypass | Healthy Free-living Individuals | Total |
|---|---|---|---|
| Ireland | 14 | 20 | 34 |
| Body weight (kg)(kg) | Gastric Bypass | Healthy Free-living Individuals | Total |
|---|---|---|---|
| Mean | 136 ± 23.8 | 65 ± 5.2 | 100.5 ± 14.5 |
| Total Food Intake (Lunch Buffet)(kJ) | Gastric Bypass | Healthy Free-living Individuals | Total |
|---|---|---|---|
| Mean | 6510.3 ± 1023 | 800 ± 50 | 3655 ± 536.5 |
| Absolute intake of fat(kJ) | Gastric Bypass | Healthy Free-living Individuals | Total |
|---|---|---|---|
| Mean | 2617.1 ± 250 | 310 ± 30 | 1448.5 ± 265 |
| Absolute intake of carbohydrates(kJ) | Gastric Bypass | Healthy Free-living Individuals | Total |
|---|---|---|---|
| Mean | 3102.4 ± 1080 | 300 ± 70 | 1701.2 ± 575 |
2 further baseline measures are reported on the registry.
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: No
Ran from Dec 2017 to primary completion in Sep 2021, 45 months.
Results were first posted in Aug 2023, 1 year 10 months after primary completion.
Of 791 non-industry observational studies under Obesity, half reached primary completion within 40 months of starting (the median), counting those still running; a quarter within 17 and three quarters within 106. This study's 45 months is above that.
Counting every sponsor, half of 836 studies reached it within 39 months; a quarter within 17 and three quarters within 96.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Oct 2022. You cannot join it, but the record below documents what was studied.
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