An interventional study of Transcutaneous Oximetry and Photopletysmography in Thoracic Outlet Syndrome, sponsored by University Hospital, Angers. Completed at 1 site in France. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-17.
Sponsored by University Hospital, Angers · Not applicable, Interventional, and Diagnostic
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Among 10 studies in Thoracic Outlet Syndrome with a site in France — 3 open to participants now, 3 under way, none of them phase 3. Thoracic Outlet Syndrome · France.
Among the 10 studies in Thoracic Outlet Syndrome with a site in France, this one is one of 3 that started in 2018, is one of 3 with no phase, and was the 1st registered.
33 studies on the registry are indexed under Thoracic Outlet Syndrome; 11 are open to participants now.
Browse Thoracic Outlet Syndrome studies →3 of the 10 studies in Thoracic Outlet Syndrome with a site in France are open now. Recruiting first, the newest first:
Nantes University Hospital · Sites in France
Ages 18+
Nantes University Hospital · Sites in France
Ages 18–99 · Healthy volunteers
University Hospital, Angers · Sites in France
Ages 18+
A study can be open while its sites in France have not opened yet or have stopped. Only those recruiting at a site in France →
Of the 8 Thoracic Outlet Syndrome studies recruiting now, 4 set no upper age limit and 3 stop at 75 or younger; 1 takes children under 18; 2 take healthy volunteers.
This study: 18 Years and older · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
10 studies; the count open now beside each. This study's row is marked.
First in 2018; this study’s year is marked. 3 started in 2018.
This study's enrollment of 222 is above the median of 50 across 17 interventional studies indexed under Thoracic Outlet Syndrome.
Median enrollment 200 across the 3 interventional studies, 101 across the 7 observational. Of the 7 that completed or were terminated, 0 (0%) have results posted.
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None of the 10 has an industry lead sponsor. The 3 most frequent:
University Hospital, Angers is the lead sponsor of 478 studies on the registry; 120 are open to participants now.
University Hospital, Angers has 6 studies filed under Thoracic Outlet Syndrome — fewer than ten, so there is no comparison to draw.
None of the studies under way reaches primary completion within a year.
Among the 10 studies in Thoracic Outlet Syndrome with a site in France, from their registry updates:
Nothing recorded among them since 2026-09-25.
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The measurement of the transcutaneous oxygen partial pressure (TCPO2) at exercise is, to our knowledge, the only method to estimate during the exercise the importance of ischemia segment of limb by segment of limb bilaterally and carry on. The diagnosis of thoracic outlet syndrome causing remains difficult and dependent operator in ultrasound because of the risk of false positive (loss of signal) or false negative (insufficient effort, inappropriate movement).
Our main hypothesis is the existence of significant measurable ischemia in the forearm by transcutaneous oximetry during the maneuvering of the "candlestick".
In the event of failure of this maneuver, the other maneuvers such as those of Wright, Roos, Tinel and Adson will be realized.
In this study we want to evaluate the possibility of using dynamic transcutaneous Oximetry as a tool for evaluating ischemia in case of suspicion of thoracic outlet syndrome causing.
Patients referred for suspected thoracic outlet syndrome causing and healthy asymptomatic subjects will be included.
After signing the consent, the subject will have a clinical and paraclinical examination. Age, sex, height, weight, side of clinical symptomatology will be collected. Medical history current treatments will also be noted.
The examination of transcutaneous oximetry dynamic measurement with palmar face of both forearms during two consecutive maneuvers known as the "candlestick" (hands up). The most symptomatic arm value in patients and the dominant arm in the control group will be noted. In case of DROP between 0 and -25 mmHg, in addition to the maneuvering of the "candlestick", the other maneuvers such as those of Wright, Roos, Tinel and Adson will be realized.
The results of any additional examinations and / or pre- and post-operative consultations will be collected.
Subjects complete two Quality of Life questionnaires: the SF-12 (Short Form 12) and the DASH questionnaire (Disabilities of the Arm, Shoulder and Hand).
Added by an amendment : Photoplethysmography has already done its proofs to determine the thoracic outlet syndrome diagnotic. Combine with a camera Kinect, they should determine the angle of appearance of compression in the 3 dimensions of space.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients suspected of thoracic outlet syndrome Transcutaneous oximetry during upper arm manoeuvers
Diagnostic Test: Transcutaneous Oximetry · Diagnostic Test: Photopletysmography · Other: Questionnaires of Quality of Life (QoL)
healthy asymptomatic subjects Transcutaneous oximetry during upper arm manoeuvers
Diagnostic Test: Transcutaneous Oximetry · Diagnostic Test: Photopletysmography · Other: Questionnaires of Quality of Life (QoL)
The examination of transcutaneous Oximetry dynamic measurement with palmar face of both forearms during two consecutive maneuvers known as the "candlestick" (hands up).
Maneuvers are repeted with the photoplestysmography sensors and in front of a Kinect camera.
Each subject complete 2 QoL questionnaires : Sf-12 (Short Form 12) and DASH (Disabilities of the Arm, Shoulder and Hand).
Decrease from Rest of Oxygen Pressure (DROP) during manoeuvers in patients and controls.
Difference in DROP observed in the symptomatic arm of patients with suspected thoracic outlet syndrome compared to the dominant arm in controls
Time frame: inclusion
Presence of stenosis or occlusion on angiography
The performance and cutoff of the DROP will be studied with the AUC (ROC curve) to predict a stenosis on angiography versus no stenosis in patients.
Time frame: 24 months
POsitive and negative DROP results
To determine the proportion of false positive and false negative results in controls using the cutoff determined in outcome 2
Time frame: 24 months
Angle of appearance of the compression observed on PPG
By combining the photopletysmography and a camera Kinect, it is possible to exactly determine the angle of appearance of the compression
Time frame: 24 months
Ran from Mar 2018 to primary completion in Jan 2024, 69 months.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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