An interventional study of Behavioral testing - computerized tasks in Dystonia, Primary, sponsored by Institut National de la Santé Et de la Recherche Médicale, France. Completed at 1 site in France. Open to participants aged 15 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-04.
Sponsored by Institut National de la Santé Et de la Recherche Médicale, France · Not applicable, Interventional, and Basic science
In this study, using computerized cognitive assessments combined with multi-modal neuroimaging approach investigators aim to address three specific questions on patients with cervical and myoclonus dystonia:
(i) investigate various aspects of the sense of agency and relationship to the severity of dystonia symptoms, (ii) characterize the possible link between abnormalities of movement perception and alteration of sense of agency in dystonia, (iii) (identify the neuronal underpinnings of the defective sense of agency in dystonia.
This is a single-centre, two-group ( dystonia and control), case-control study using behavioural and novel multimodal neuroimaging techniques to address the study aims.
The battery of the tasks will include explicit-agency tasks, a visual discrimination task on objects movement perception. The magnetic resonance acquisition protocol will include MP2RAGE structural (10 min duration), multi echo (3 echo times) multiband (MB factor 4) resting state functional neuroimaging (15 minutes duration) and multi shell diffusion imaging sequence (15 minutes duration)
95 studies on the registry are indexed under Dystonic Disorders; 19 are open to participants now.
This study's enrollment of 76 is above the median of 24 across 45 interventional studies indexed under Dystonic Disorders.
Browse Dystonic Disorders studies →Institut National de la Santé Et de la Recherche Médicale, France is the lead sponsor of 378 studies on the registry; 81 are open to participants now.
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Exclusion Criteria
25 patients with cervical and 25 patients with myoclonus dystonia
Behavioral: Behavioral testing - computerized tasks
50 healthy volunteers matched to patents ( age, sex)
Behavioral: Behavioral testing - computerized tasks
Cognitive behavioral testing and cerebral MRI
agency tasks behavioral outcome measures
response time
Time frame: throughout study completion, an average 2 years
agency tasks behavioral outcome measures
response accuracy in tasks trials
Time frame: throughout study completion, an average 2 years
MRI measures
cortical thickness
Time frame: throughout study completion, an average 2 years
MRI measures
basal ganglia volume
Time frame: throughout study completion, an average 2 years
This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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