An observational study in Diabetes Mellitus, Type 2, Hypertension and Vitamin D Deficiency, sponsored by Washington University School of Medicine. Active, not recruiting at 2 sites in United States. Open to participants aged 25 Years to 80 Years. Per ClinicalTrials.gov, last updated 2025-12-24.
Sponsored by Washington University School of Medicine · Observational
This trial will evaluate whether a particular type of circulating white blood cell, monocytes, from type 2 diabetics with high blood pressure and vitamin D deficiency vs. sufficiency will induce hormones that increase blood pressure.
More than half of patients with type 2 diabetes mellitus develop hypertension, which doubles their risk for cardiovascular disease. Inflammation plays a role in the development of these diseases, and monocytes, a type of white blood cell, may be critical. This study will isolate monocytes from blood samples of patients with type 2 diabetes and high blood pressure who have either high levels of vitamin D or low levels of vitamin D, and determine what their effects are on stimulating production in kidney cells of a hormone that increases blood pressure.
T2DM patients with hypertension
Exclusion Criteria:
Type 2 diabetics with high blood pressure and 25-hydroxyvitamin D levels of \<20 ng/ml
Diagnostic Test: Blood draw
Type 2 diabetics with high blood pressure and 25-hydroxyvitamin D levels of \>30 ng/ml
Diagnostic Test: Blood draw
Blood will be drawn to isolate monocytes after 2 weeks off of blood pressure lowering medications.
Renin production by monocytes
Blood will be collected for isolation of monocytes. These cells will then be cultured to determine whether there is monocyte stimulation of a hormone that induces high blood pressure (renin) in kidney cells.
Time frame: 2 weeks
Renin production by monocyte media
Blood will be collected for isolation of monocytes. The media from these cells will then be added to culture to determine whether there is stimulation of a hormone that induces high blood pressure (renin) in kidney cells.
Time frame: 2 weeks
Plan to share: No
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
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Washington University School of Medicine