CClinicalTrials.gg
TerminatedNCT03343756PROLONGSTEMUpdated May 29, 2024

HepaStem Long-Term Safety Registry

An observational study in Urea Cycle Disorder, Crigler-Najjar Syndrome and Acute on Chronic Liver Failure, sponsored by Cellaion SA. Terminated at 29 sites in 5 countries. Open to participants aged 5 Years to 75 Years. Per ClinicalTrials.gov, last updated 2024-05-29.

Sponsored by Cellaion SA · Observational

Why this study was terminated
Sponsor decision related to product development prioritisation.
Study type
Observational
Model
Other
Time perspective
Other
Enrollment
44
Ages
5 Years to 75 Years
Sex
All
01

Study summary

All patients having received at least one infusion of the Investigational Medicinal Product (IMP) HepaStem HHALPC during a previous interventional clinical study conducted by Promethera Biosciences

02

Conditions studied

  • Urea Cycle Disorder
  • Crigler-Najjar Syndrome
  • Acute on Chronic Liver Failure
03

Who can participate

Ages eligible
5 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients who received HepaStem in the interventional studies conducted by Promethera will be proposed to participate in this PROLONGSTEM study.

Inclusion criteria

  • All patients having received at least one infusion of HepaStem during a previous interventional clinical study conducted by Promethera.

Exclusion criteria

Exclusion Criteria:

  • Patients who received an OLT and completed 6-month FU documentation prior to the start of the PROLONGSTEM study.
  • Patients who have received mature liver cells or stem cells other than HepaStem prior to the start of the PROLONGSTEM study.
04

Study design

Observational model
Other
Time perspective
Other
Enrollment
44 participants (actual)
Patient registry
No
05

What researchers measure

Primary outcomes

  1. Occurrence of Adverse Events of Specific Interest (AESI)

    Adverse Events of Specific Interest (AESI): * Event with fatal outcome (Death) * Orthotopic Liver Transplantation (OLT) and Outcome. * Development of Malignancy or unwanted tissue formation in different organs (tumor malignant or not). * Disease linked to transmission of adventitious agents or reactivation of latent pathogens. * Any AE which in the opinion of the Investigator has a plausible causal relationship to HepaStem.

    Time frame: 60 months

06

Study locations

29 sites
  • Hopital Erasme
    Anderlecht, 1070, Belgium
  • Antwerp University Hospital
    Antwerp, 2650, Belgium
  • Association Hospitaliere De Bruxelles Et De Schaerbeek Centre Hospitalier Universitaire Brugmann
    Brussels, 1020, Belgium
  • UCL
    Brussel, 1200, Belgium
  • Universitair Ziekenhuis Gent
    Gent, 9000, Belgium
  • UZ Leuven
    Leuven, 3000, Belgium
  • CHC MontLegia
    Liège, 4000, Belgium
  • Cliniques Universitaires Saint-Luc
    Woluwe-Saint-Lambert, Belgium
  • University Multiprofile Hospital For Active Treatment Dr. Georgi Stranski EAD
    Pleven, 5803, Bulgaria
  • UMHAT Medica Ruse
    Ruse, 7013, Bulgaria
  • Military Medical Academy
    Sofia, 1606, Bulgaria
  • Centre Hospitalier Universitaire Amiens Picardie
    Amiens, 80080, France
  • Centre Hospitalier Universitaire D'Angers
    Angers, 49933, France
  • University Hospital Of Bordeaux
    Bordeaux, 33608, France
  • CHU Lille
    Lille, 59037, France
  • Hospices Civils De Lyon
    Lyon, 69317, France
  • Assistance Publique Hopitaux De Marseille
    Marseille, 13005, France
  • Centre Hospitalier Universitaire De Montpellier
    Montpellier, 34295, France
  • Assistance Publique Hopitaux De Paris
    Paris, 75013, France
  • Les Hopitaux Universitaires De Strasbourg
    Strasbourg, 67000, France
  • CHU Toulouse
    Toulouse, 31059, France
  • Hopital Paul Brousse
    Villejuif, 94804, France
  • Id Clinic
    Mysłowice, 41-400, Poland
  • Hospital De La Santa Creu I Sant Pau
    Barcelona, 08025, Spain
  • Hospital Universitari Vall D'Hebron
    Barcelona, 8035, Spain
  • Hospital General Universitario Gregorio Maranon
    Madrid, 28009, Spain
  • Hospital Universitario Ramon Y Cajal
    Madrid, 28049, Spain
  • Parc Tauli Hospital Universitari
    Sabadell, 08208, Spain
  • Hospital Unviersitario Miguel Servet
    Zaragoza, 50009, Spain
07

Registry details

Key details

Study ID
NCT03343756
Lead sponsor
Cellaion SA
Responsible party
Sponsor
First posted
Nov 17, 2017
Start date
Apr 4, 2018
Primary completion
May 23, 2024
Completion
May 23, 2024
Last update
May 29, 2024

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in May 2024. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion