An interventional study of cycling exercise in Parkinson Disease, sponsored by Pacific Parkinson's Research Centre. Completed at 1 site in Canada. Open to participants aged 40 Years to 80 Years. Per ClinicalTrials.gov, last updated 2020-03-04.
Sponsored by Pacific Parkinson's Research Centre · Not applicable, Interventional, and Treatment
Among 253 studies in Parkinson Disease with a site in Canada — 43 open to participants now, 62 under way, 3 of them phase 3. Parkinson Disease · Canada.
Among the 253 studies in Parkinson Disease with a site in Canada, this one is the 162nd largest by enrollment of the 212 interventional ones that give a count, is one of 10 that started in 2013, is one of 95 with no phase, and was the 122nd registered.
4,573 studies on the registry are indexed under Parkinson Disease; 1,086 are open to participants now.
Browse Parkinson Disease studies →43 of the 253 studies in Parkinson Disease with a site in Canada are open now. Recruiting first, the newest first:
Vima Therapeutics · Sites in Canada, United States
AbbVie · Sites in Canada, United States, Croatia and 6 more countries
Centre intégré de santé et de services sociaux de l'Outaouais · Sites in Canada
Regeneron Pharmaceuticals · Sites in Canada, Netherlands
University Health Network, Toronto · Sites in Canada
A study can be open while its sites in Canada have not opened yet or have stopped. Only those recruiting at a site in Canada →
Of the 748 Parkinson Disease studies recruiting now, 311 (42%) set no upper age limit and 127 (17%) stop at 75 or younger; 63 take children under 18; 189 take healthy volunteers.
This study: 40 Years to 80 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
253 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 16 · Phase 2 47 · Phase 3 57 · Phase 4 4
First in 1998; this study’s year is marked. 10 started in 2013.
This study's enrollment of 23 is below the median of 40 across 3,353 interventional studies indexed under Parkinson Disease.
Median enrollment 60 across the 212 interventional studies, 315 across the 41 observational. Of the 158 that completed or were terminated, 60 (38%) have results posted.
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103 of 253 have an industry lead sponsor. The 10 most frequent:
Pacific Parkinson's Research Centre is the lead sponsor of 7 studies on the registry; none are open to participants now.
Pacific Parkinson's Research Centre has 7 studies filed under Parkinson Disease — fewer than ten, so there is no comparison to draw.
13 of the studies in Parkinson Disease with a site in Canada that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06529744University Health Network, TorontoImproving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling | 2026-11 |
| NCT04426786Pacific Parkinson's Research CentreExercise & Brain Energetics in PD | 2026-12-30 |
| NCT07443293University of British ColumbiaIMPACT 360 for Parkinson's Disease | 2026-12-31 |
| NCT05913687University of FloridaAutomated Imaging Differentiation of Parkinsonism | 2027-03-31 |
| NCT05897957BlueRock TherapeuticsContinued Evaluation of Patients With Parkinson's Disease Who Previously Received BRT-DA01 | 2027-05 |
Among the 253 studies in Parkinson Disease with a site in Canada, from their registry updates:
This tab as a report to print or save as PDF → With an account.
To assess 30 active people (15 with PD, 15 without) before and after 30 minutes of pedaling exercise using EEG-EMG, cognitive, mood and motor assessments.
Purpose: To assess 15 subjects with PD and 15 healthy controls, who exercise on a regular basis, before, during and after 30 minutes of pedaling exercise intervention. The investigators will assess subjects for alterations in motor cortex assessment, cognition and mood as measured by EMG/EEG, motor assessment and several batteries of questionnaires. Findings from this study will lay the foundation for long-term studies.
Hypotheses: The investigators anticipate to observe an altered involvement of motor cortex during steady pedaling in individuals suffering from PD. In healthy control subjects it is anticipated that changes in cognition will be observable.
Justification: Hindered movement initiation and continuing locomotion is a common syndrome in PD with profound impact on the patient's mobility and quality of life. So far, the underlying pathophysiology is not completely understood. Since the observation that cortical activity contributes to the muscle activity during locomotion-like tasks underpins the importance of corticospinal function in humans, it is of importance to examine whether this cortical involvement is altered and displays abnormalities in patients with PD. Thus, the approach of corticomuscular coupling during a locomotion-like task would allow for better understanding of the pathophysiology of PD, a prerequisite to develop therapies. Findings of this study will lay the foundation for future long-term studies.
Additionally, by examining the oscillatory EEG patterns during the exercise intervention, the investigator will be able to read out the dose response curve in real time, which will provide information on the optimum intensity and duration of exercise. Findings will help to design future studies and to develop efficient exercise therapy interventions for people with PD.
People living with PD often suffer from cognitive decline, depression, and fatigue. By assessing cognitive function before and after the exercise intervention, there will be laid a foundation for future studies investigating the effect of exercise on cognition. The collected pilot data will be relevant to learn more about the effects of exercise on mood and fatigue as well as concomitant obstacles and facilitators during exercise interventions in patients with PD.
Objectives: The primary objective of this study is to investigate if activity that arises in the motor cortex and contributes to the muscle activity during moderate pedaling is altered in patients with PD compared to healthy gender- and age-matched controls. Thus, to better understand the role of the motor cortex and its contribution in simple automated repetitive tasks in patients with PD there will be analysis of the coherence of the coupling between EEG and EMG from active leg muscles during cycling on a stationary bicycle both in subjects with PD and age and gender matched healthy controls.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Subjects with Parkinson's disease
Other: cycling exercise
Subjects without Parkinson's disease
Other: cycling exercise
5 x 3 minute bouts of cycling exercise separated by 3 minute rest periods
EEG-EMG coherence
Coherence of the coupling between EEG and EMG from active leg muscles during cycling on a stationary bicycle both in subjects with PD and age and gender matched healthy controls.
Time frame: The change from immediately before, during, and immediatly after the single bout of exercise.
Motor function
Examine motor function with the Movement disorders society unified Parkinson's disease rating scale motor section (MDS-UPDRS III)
Time frame: Immediately before and after the single bout of exercise.
Motor function
Examine motor function with the finger tapping
Time frame: Immediately before and after the single bout of exercise.
Motor function
Examine motor function with the Purdue pegboard
Time frame: Immediately before and after the single bout of exercise.
Motor function
Examine motor function with the Timed-up-and-go (TUG)
Time frame: Immediately before and after the single bout of exercise.
Cognitive function
Examine cognitive function with Montreal cognitive assessment (MoCA)
Time frame: Immediately before, after and at 3 hours following the single bout of exercise.
Cognitive function
Examine cognitive function with Verbal fluency
Time frame: Immediately before, after and at 3 hours following the single bout of exercise.
Cognitive function
Examine cognitive function with trail making test (A and B) and reaction time
Time frame: Immediately before, after and at 3 hours following the single bout of exercise.
Mood function
Examine mood with the Positive and Negative Affect Schedule.
Time frame: Immediately before, after and at 3 hours following the single bout of exercise.
Mood function
Examine mood with the Starkein Apathy scale
Time frame: Immediately before, after and at 3 hours following the single bout of exercise.
Plan to share: No
No publications or documents are linked to this record.
Ran from Apr 2013 to primary completion in Dec 2014, 20 months.
Of 1,291 non-industry interventional studies with no phase under Parkinson Disease, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 44. This study's 20 months is below that.
Counting every sponsor, half of 1,367 studies reached it within 25 months; a quarter within 11 and three quarters within 44.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Mar 2020. You cannot join it, but the record below documents what was studied.
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Pacific Parkinson's Research Centre