An interventional study of Exercise intervention in Colorectal Cancer, sponsored by NHS Greater Glasgow and Clyde. Status unknown at 4 sites in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-11-08.
Sponsored by NHS Greater Glasgow and Clyde · Not applicable, Interventional, and Other
Among 387 studies in Colorectal Neoplasms with a site in United Kingdom — 73 open to participants now, 101 under way, 18 of them phase 3. Colorectal Neoplasms · United Kingdom.
Among the 387 studies in Colorectal Neoplasms with a site in United Kingdom, this one is the 207th largest by planned enrollment of the 299 interventional ones that give a count, is one of 11 that started in 2018, is one of 64 with no phase, and was the 205th registered.
6,541 studies on the registry are indexed under Colorectal Neoplasms; 1,667 are open to participants now.
Browse Colorectal Neoplasms studies →73 of the 387 studies in Colorectal Neoplasms with a site in United Kingdom are open now. Recruiting first, the newest first:
Imperial College London · Sites in United Kingdom
Dr. Chris Gaffney · Sites in United Kingdom
University of Edinburgh · Sites in United Kingdom
University of Edinburgh · Sites in United Kingdom
EMD Serono Research & Development Institute, Inc. · Sites in United Kingdom, United States, Argentina and 16 more countries
A study can be open while its sites in United Kingdom have not opened yet or have stopped. Only those recruiting at a site in United Kingdom →
Of the 1,185 Colorectal Neoplasms studies recruiting now, 769 (65%) set no upper age limit and 265 (22%) stop at 75 or younger; 48 take children under 18; 123 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
387 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 94 · Phase 2 119 · Phase 3 77 · Phase 4 3
First in 1993; this study’s year is marked. 11 started in 2018.
This study's planned enrollment of 72 is close to the median of 76 across 4,800 interventional studies indexed under Colorectal Neoplasms.
Median enrollment 150 across the 299 interventional studies, 275 across the 79 observational. Of the 233 that completed or were terminated, 81 (35%) have results posted.
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193 of 387 have an industry lead sponsor. The 10 most frequent:
NHS Greater Glasgow and Clyde is the lead sponsor of 220 studies on the registry; 39 are open to participants now.
NHS Greater Glasgow and Clyde has 2 studies filed under Colorectal Neoplasms — fewer than ten, so there is no comparison to draw.
25 of the studies in Colorectal Neoplasms with a site in United Kingdom that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT04486378BioNTech SEA Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer | 2026-11 |
| NCT06607458Delcath Systems Inc.Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease | 2026-12 |
| NCT07151040One-carbon Therapeutics ABPhase 1/2 Study to Evaluate TH9619 in the Treatment of Advanced Solid Tumors | 2026-12 |
| NCT02222844Imperial College LondonImproving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers | 2026-12 |
| NCT02246634Imperial College LondonScreening for Synchronous Metastases in Colorectal Cancer With DW-MRI (SERENADE) | 2026-12 |
Among the 387 studies in Colorectal Neoplasms with a site in United Kingdom, from their registry updates:
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This study examines whether a home-based telephone-guided preoperative exercise programme is feasible and effective in improving cardiorespiratory fitness in patients with colorectal cancer who are high risk due to their existing co-morbidity.
Preoperative exercise, also know as prehabilitation, has been shown to improve physical fitness and potentially reduce postoperative complications in patients undergoing surgery. Patients are often labelled high risk for surgery due to their existing ill-health e.g. heart and lung disease. High risk patients comprise approximately 12% of all elective cancer cases, but account for 80% of all post-operative mortality. Complications significantly affect the quality of life of each CRC patient, both in the short and long-term, and can also impact on survival. It is critical that patients who are deemed at high risk of complications are optimised in the preoperative period. Exercise in the period before surgery is therefore one potential method of improving high risk patients' physical fitness levels while potentially reducing their risk of postoperative complications and subsequent mortality.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Behavioral: Exercise intervention
Graduated walking programme, strengthening exercises and respiratory muscle training.
Change in cardiorespiratory fitness
Anaerobic threshold as measured by CPET
Time frame: Preoperative period: 4 weeks
Length of stay in high dependency and intensive care
Critical Care bed days
Time frame: Postoperative period: up to 8 weeks
Readmission to critical care
Critical Care bed days
Time frame: Postoperative period: up to 8 weeks (within index admission)
Time to medical discharge
Medically fit for discharge
Time frame: Postoperative period: up to 8 weeks.
Hospital length of stay
Days
Time frame: Postoperative period: within 30 days.
Readmission rate
Time frame: Within 30 days of discharge.
Post-operative morbidity
Clavien-Dindo Scale
Time frame: Post-operative period: at 30 days post-surgery (week 8).
Health-related quality of life
SF-36
Time frame: Baseline (week 0), post-intervention (week 4), at 30 days postoperatively (week 8).
Health-related quality of life
EORTC QLQ-C30
Time frame: Baseline (week 0), post-intervention (week 4), at 30 days postoperatively (week 8).
Psychological health
Hospital Anxiety and Depression Score (HADS)
Time frame: Baseline (week 0), post-intervention (week 4), at 30 days postoperatively (week 8).
Frailty
Clinical Frailty Score (CSHA)
Time frame: Baseline (week 0) and repeat testing (week 4).
Redox blood samples
Redox status in pre- and post-exercise blood samples
Time frame: Baseline (week 0) and repeat CPET (week 4).
Survival
Overall and cancer-specific
Time frame: 3 years post-operatively.
Feasibility of home-based exercise
Recruitment, retention, adherence rates
Time frame: Preoperative period: 4 weeks.
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Apr 2018; primary completion for Apr 2020, 24 months later.
Of 898 non-industry interventional studies with no phase under Colorectal Neoplasms, half reached primary completion within 32 months of starting (the median), counting those still running; a quarter within 15 and three quarters within 62. This study's planned 24 months is below that.
Counting every sponsor, half of 955 studies reached it within 32 months; a quarter within 14 and three quarters within 60.
How these figures are worked out, and which studies are left out of them.
This study is status unknown, as verified in Sep 2017. You cannot join it, but the record below documents what was studied.
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NHS Greater Glasgow and Clyde →