ClinicalTrials.gg
Active, not recruitingNCT03324698Updated Sep 23, 2026

The Natural History of Chronic Pancreatitis

An observational study in Chronic Pancreatitis, Complication and Risk Factors, sponsored by Changhai Hospital. Active, not recruiting at 1 site in China. Per ClinicalTrials.gov, last updated 2026-09-23.

Sponsored by Changhai Hospital · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
4,000
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 41 studies in Pancreatitis, Chronic by Changhai Hospital — 13 open to participants now, 18 under way, none of them phase 3. Pancreatitis, Chronic · Changhai Hospital.

Planned enrollment
4th of 28
4,000 · median 657
Started
2000
with 1 other
Observational
28 of 41
9 open now
Primary completion
2026-12
later than 10 of 17 live
Registered
3rd of 41
by date

Among the 41 studies in Pancreatitis, Chronic by Changhai Hospital, this one is the 4th largest by planned enrollment of the 28 observational ones that give a count, is one of 2 that started in 2000, is one of 28 observational ones, reaches primary completion later than 10 of the 17 other live ones, and was the 3rd registered.

Pancreatitis, Chronic

264 studies on the registry are indexed under Pancreatitis, Chronic; 76 are open to participants now.

Browse Pancreatitis, Chronic studies →

Open to participants now

13 of the 41 studies in Pancreatitis, Chronic by Changhai Hospital are open now, in 1 country. Recruiting first, the newest first:

8 more — sign in →

By country, each count listing its studies:

All 13 open studies →

Where they have run

Who these studies take

Of the 49 Pancreatitis, Chronic studies recruiting now, 31 (63%) set no upper age limit and 12 (24%) stop at 75 or younger; 8 take children under 18; 11 take healthy volunteers.

This study: all sexes · no healthy volunteers.

The full table on the hub →

This tab as a report to print or save as PDF → With an account.

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Watch this landscapeDownload CSVNarrow it in search →With an account: a weekly mail of what changed among 41 studies in Pancreatitis, Chronic by Changhai Hospital, or all of them as a file.
02

Study summary

Chronic pancreatitis (CP) is a disease characterized by inflammation and their replacement by fibrotic tissue. The destruction of pancreatic function and structure are the main complications. This retrospective-prospective, multicenter, cohort study was conducted. This study aimed to observe the natural history of CP in China, analyse the risk factors for CP complications, and establish individual predictions.

Read the detailed description

In order to track changes consistently throughout the course of CP and facilitate the evaluation and study of CP, a dedicated database, CP Database (version number 2.1, YINMA Information Technology Inc., Shanghai, China), was established to collect clinical data of CP patients who were admitted to our centers. Data befor CP Database established were retrospectively collected according to the electronic medical record system and complemented through telephone, letter, and e-mail inquiries. Data were prospectively collected since CP Database was established. The following information was documented in detail: demographic data (age, sex, birthplace, et al), course of CP, medical history, history of other diseases, smoking and alcohol history, family history of pancreatic diseases and diabetes mellitus (DM), laboratory and imaging findings, and treatment strategy.

03

Conditions studied

  • Chronic Pancreatitis
  • Complication
  • Risk Factors

Browse trials for

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Chronic pancreatitis patients in China

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients diagnosed with chronic pancreatitis according to Asia-Pacific consensus

Exclusion criteria

Exclusion Criteria:

  • Pancreatic cancer diagnosed within 2 years after the diagnosis of chronic pancreatitis
  • Groove pancreatitis
  • pancreatitis
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Autoimmune disease

A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.

Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.

05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
4,000 participants (estimated)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Pancreatic cancer

    Pancreatic cancer developed in chronic pancreatitis patients

    Time frame: Dec 31, 2017

  2. Diabetes mellitus

    Endocrine insufficiency developed in chronic pancreatitis patients

    Time frame: Dec 31, 2017

  3. Steatorrhea

    Exocrine insufficiency developed in chronic pancreatitis patients

    Time frame: Dec 31, 2017

  4. Pancreatic pseudocyst

    Pancreatic pseudocyst developed in chronic pancreatitis patients

    Time frame: Dec 31, 2017

  5. Common bile duct stricture

    Common bile duct stricture developed in chronic pancreatitis patients

    Time frame: Dec 31, 2017

07

Study locations

1 site
08

References and documents

Publications

  • Li BR, Pan J, Du TT, Liao Z, Ye B, Zou WB, Chen H, Ji JT, Zheng ZH, Wang D, Lin JH, Ning SB, Hu LH, Li ZS. Risk Factors for Steatorrhea in Chronic Pancreatitis: A Cohort of 2,153 Patients. Sci Rep. 2016 Feb 15;6:21381. doi: 10.1038/srep21381. PubMed 26877248 ↗
  • Hao L, Pan J, Wang D, Bi YW, Ji JT, Xin L, Liao Z, Du TT, Lin JH, Zhang D, Zeng XP, Ye B, Zou WB, Chen H, Xie T, Li BR, Zheng ZH, Hu LH, Li ZS. Risk factors and nomogram for pancreatic pseudocysts in chronic pancreatitis: A cohort of 1998 patients. J Gastroenterol Hepatol. 2017 Jul;32(7):1403-1411. doi: 10.1111/jgh.13748. PubMed 28127800 ↗
  • Hao L, Zeng XP, Xin L, Wang D, Pan J, Bi YW, Ji JT, Du TT, Lin JH, Zhang D, Ye B, Zou WB, Chen H, Xie T, Li BR, Zheng ZH, Wang T, Guo HL, Liao Z, Li ZS, Hu LH. Incidence of and risk factors for pancreatic cancer in chronic pancreatitis: A cohort of 1656 patients. Dig Liver Dis. 2017 Nov;49(11):1249-1256. doi: 10.1016/j.dld.2017.07.001. Epub 2017 Jul 15. PubMed 28756974 ↗
  • Hao L, Bi YW, Zhang D, Zeng XP, Xin L, Pan J, Wang D, Ji JT, Du TT, Lin JH, Ye B, Zou WB, Chen H, Xie T, Li BR, Zheng ZH, Wang T, Guo HL, Liao Z, Li ZS, Hu LH. Risk Factors and Nomogram for Common Bile Duct Stricture in Chronic Pancreatitis: A Cohort of 2153 Patients. J Clin Gastroenterol. 2019 Mar;53(3):e91-e100. doi: 10.1097/MCG.0000000000000930. PubMed 28961573 ↗
09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Started Jan 2000 (actual). Primary completion is estimated for Dec 2026, 323 months after the start.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 25, 2017
First posted
Oct 30, 2017
StartActual
Jan 1, 2000
Primary completionEst.
Dec 31, 2026
CompletionEst.
Jan 31, 2027
Last update
Sep 23, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Sep 23, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03324698
Lead sponsor
Changhai Hospital
Collaborators
Shenzhen People's Hospital, Zhongda Hospital, The Affiliated Hospital of Qingdao University, Yangzhou University, Jinling Hospital, China, The First People's Hospital of Hefei, Zaozhuang Central Hospital of Shandong Health Group, The Third People's Hospital of Chengdu, Ruijin Hospital, 900th Hospital of PLA Joint Logistic Support Force, Air Force Medical Center of PLA, The Fifth Medical Center of Chinese People's Liberation Army General Hospital, The Affiliated Hospital of Technical University of Munich
Responsible party
Zhaoshen Li (Director of Gastroenterology Dept., Changhai Hospital) — Principal investigator
First posted
Oct 30, 2017
Start date
Jan 1, 2000
Primary completion
Dec 31, 2026 (estimated)
Completion
Jan 31, 2027 (estimated)
Last update
Sep 23, 2026

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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