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Active, not recruitingNCT03319758Updated Feb 9, 2021

Esthetic and Radiographic Outcomes Following Immediate Implant Placement With Thin or Dehiscence Buccal Bone Wall

An interventional study of buccal bone augmentation in Jaw, Edentulous, Partially and Acquired Absence of Single Tooth, sponsored by Sun Yat-sen University. Active, not recruiting at 1 site in China. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2021-02-09.

Sponsored by Sun Yat-sen University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
15
Allocation
Not applicable
Ages
18 Years to 70 Years
Sex
All
01

Study summary

The aim of this prospective study was to evaluate the soft and hard tissue changes of immediate implant placement with buccal bone augmentation in sites with thin labial bone wall in the anterior maxillary zone.

Read the detailed description

The objective of this prospective controlled clinical trial is to compare the esthetic and radiographic outcomes following immediate implant placement with thin or dehiscences buccal plate using bone augmentation in combination with an absorbable collagen membrane. Subjects in need of one implant replacing tooth to be removed in the maxilla within region 13-23 are included. At least 15 patients are recruited. No implant-supported temporary restorations are used during the first 4 months. After a screw-retained provisional phase of 2 months, a final impression is taken at implant level and take-in definitive crown. Patients are recalled for oral hygiene maintenance and prosthetic controls every 6 months for the entire duration of the study.

02

Conditions studied

  • Jaw, Edentulous, Partially
  • Acquired Absence of Single Tooth

Keywords

  • bone augmentation
  • esthetics
  • immediate implant
  • buccal bone defects
03

Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

The inclusion criteria were as follows:

  1. 18 to 70-year-old;
  2. Stable periodontal and systemic health (American Society of Anesthesiologists classification I or II);
  3. Single maxillary anterior teeth (canine to canine);
  4. Bone thickness less than 1mm at 4mm apical to cementum-enamel junction (CEJ-4);
  5. Presence of adjacent nature tooth;
  6. Good compliance;
  7. No palatal vertical bone loss;
  8. Good oral hygiene.

Exclusion criteria are as follow:

  1. Uncontrolled periodontal or systemic disease;
  2. General psychiatric contraindications;
  3. More than 20 cigarettes per day;
  4. History of head and neck radiotherapy;
  5. Pregnant or expecting to be pregnant;
  6. Patients with local or generalized healing limitations;
  7. Bruxism or other destructive parafunctional habits;
  8. Drug abuse or alcohol abuse.
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
15 participants (estimated)

Study arms

  • Experimental
    thin or dehiscences buccal plate

    Immediate implant placement used bone augmentation in combination with an absorbable collagen membrane with thin or dehiscences buccal plate.

    Procedure: buccal bone augmentation

Interventions

  • Procedurebuccal bone augmentation

    Subjects in need of one implant replacing tooth to be removed in the maxilla within region 13-23 are included. At least 15 patients are recruited.

05

What researchers measure

Primary outcomes

  1. Radiographic bone volume

    Radiographic bone volume be assessed at pre-operation, 0 ,0.5, 1, 1.5, 3.5, 5.5, 7.5, 10.5 years after implant placement.

    Time frame: Up to 10 years after baseline

Secondary outcomes

  1. Change of Pink and white esthetic scores (PES/WES)

    Baseline will be at the time of implant placement.Pink and white esthetic scores (PES/WES) will be recorded at 0.5, 1.5, 3.5, 5.5, 7.5, 10.5 years after implant placement.

    Time frame: Change from baseline up to 10 years after implantation

  2. Visual analogue scale (VAS)

    A questionnaire will be recorded at pre-operation, 0.5, 1, 1.5, 3.5, 5.5, 7.5, 10.5 years after implant placement

    Time frame: Up to 10 years after baseline

  3. Oral health impact profile shortened version (OHIP-I)

    A questionnaire will be recorded at pre-operation, 0.5, 1, 1.5, 3.5, 5.5, 7.5, 10.5 years after implant placement.

    Time frame: Up to 10 years after baseline

  4. Buccal marginal recession

    Buccal marginal recession will be assessed at pre-operation, 0.5, 1, 1.5, 3.5, 5.5, 7.5, 10.5 years after implant placement.

    Time frame: Up to 10 years after baseline

  5. Papilla volume

    Papilla volume will be assessed at 0.5, 1, 1.5, 3.5, 5.5, 7.5, 10.5 years after implant placement.

    Time frame: Up to 10 years after baseline

  6. Width of keratinized gingiva

    Width of keratinized gingiva will be assessed at 0.5, 1, 1.5, 3.5, 5.5, 7.5, 10.5 years after implant placement.

    Time frame: Up to 10 years after baseline

  7. Implant survival

    Implant survival will be assessed at 0.5, 1, 1.5, 3.5, 5.5, 7.5, 10.5 years after implant placement.

    Time frame: Up to 10 years after baseline

  8. Probing depth

    Probing depth will be assessed at pre-operation, 0.5, 1, 1.5, 3.5, 5.5, 7.5, 10.5 years after implant placement.

    Time frame: Up to 10 years after baseline

  9. Modified plaque index

    Modified plaque index will be assessed at pre-operation, 0.5, 1, 1.5, 3.5, 5.5, 7.5, 10.5 years after implant placement.

    Time frame: Up to 10 years after baseline

  10. Modified bleeding index

    Modified bleeding index will be assessed at pre-operation, 0.5, 1, 1.5, 3.5, 5.5, 7.5, 10.5 years after implant placement.

    Time frame: Up to 10 years after baseline

06

Study locations

1 site
  • Guanghua School of Stomatology,Hospital of Stomatology,Sun Yat-Sen University
    Guangzhou, Guangdong 510000, China
07

References and documents

Publications

  • Sarnachiaro GO, Chu SJ, Sarnachiaro E, Gotta SL, Tarnow DP. Immediate Implant Placement into Extraction Sockets with Labial Plate Dehiscence Defects: A Clinical Case Series. Clin Implant Dent Relat Res. 2016 Aug;18(4):821-9. doi: 10.1111/cid.12347. Epub 2015 Apr 27. PubMed 25916859 ↗
  • Barone A, Ricci M, Romanos GE, Tonelli P, Alfonsi F, Covani U. Buccal bone deficiency in fresh extraction sockets: a prospective single cohort study. Clin Oral Implants Res. 2015 Jul;26(7):823-30. doi: 10.1111/clr.12369. Epub 2014 Mar 31. PubMed 24684275 ↗
  • Aloy-Prosper A, Penarrocha-Oltra D, Penarrocha-Diago M, Penarrocha-Diago M. Dental implants with versus without peri-implant bone defects treated with guided bone regeneration. J Clin Exp Dent. 2015 Jul 1;7(3):e361-8. doi: 10.4317/jced.52292. eCollection 2015 Jul. PubMed 26330931 ↗

Individual participant data

Plan to share: Undecided

08

Registry details

Key details

Study ID
NCT03319758
Lead sponsor
Sun Yat-sen University
Responsible party
Baoxin Huang (Principal Investigator, Sun Yat-sen University) — Principal investigator
First posted
Oct 24, 2017
Start date
May 2016
Primary completion
Nov 2026 (estimated)
Completion
Nov 2027 (estimated)
Last update
Feb 9, 2021

Study contacts

Baoxin Huang, PhD
principal investigator · Sun Yat-sen University

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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