An interventional study of Air purifier in Cardiopulmonary Disease, sponsored by Peking University. Completed at 1 site in China. Open to participants aged 10 Years to 14 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-05-23.
Sponsored by Peking University · Not applicable, Interventional, and Prevention
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The objective of this study is to investigate the cardiopulmonary health effects of indoor air purification and different indoor environmental factors among school students in Beijing.
This randomized, double-blind crossover study was conducted to explore the cardiopulmonary effects of ionization air purification among 48 children in Beijing. Real or sham purification was performed in classrooms for 5 weekdays in a random order with a 2-month wash-out period. During the study periods, different indoor environmental factors were monitored including size-fractionated particulate matter (PM), black carbon (BC), ozone, carbon dioxide (CO2), negative air ions (NAI), noise, temperature and relative humidity, which were controlled as confounders in the analysis of the effects of indoor air purification. In addition, we analyzed the cardiopulmonary effects of those environmental factors on the children.
42 studies on the registry are indexed under Pulmonary Heart Disease; 6 are open to participants now.
This study's enrollment of 48 is close to the median of 50 across 23 interventional studies indexed under Pulmonary Heart Disease.
Browse Pulmonary Heart Disease studies →Peking University is the lead sponsor of 419 studies on the registry; 123 are open to participants now.
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Exclusion Criteria:
Air purifier turned on
Other: Air purifier
Air purifier turned off
Other: Air purifier
active- or sham-mode air purifier used in 6 classrooms in a school with a crossover design
Levels of lung function indicators
Lung function test was conducted including forced expiratory volume in one second (FEV1) and peak expiratory flow (PEF).
Time frame: 10 weekdays for intervention (active or sham) and 2 wash-out months
Changes in autonomic cardiac function
Ambulatory electrocardiogram (ECG) was monitored including heart rate (HR) and heart rate variability (HRV).
Time frame: 10 weekdays for intervention (active or sham) and 2 wash-out months
Level of respiratory inflammation
Fractional exhaled nitric oxide (FeNO) test was conducted.
Time frame: 10 weekdays for intervention (active or sham) and 2 wash-out months
Changes in ST-segment elevation
Ambulatory electrocardiogram (ECG) was monitored.
Time frame: 10 weekdays for intervention (active or sham) and 2 wash-out months
Levels of oxidative stress in Exhaled Breath Condensate (EBC)
EBC was collected using a designated device for oxidative stress analysis.
Time frame: 10 weekdays for intervention (active or sham) and 2 wash-out months
Levels of urinary metabolomics
Urine samples were collected for metabolomics analysis.
Time frame: 10 weekdays for intervention (active or sham) and 2 wash-out months
Ran from Dec 2017 to primary completion in Apr 2018, 3 months.
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This study is completed, as verified in May 2019. You cannot join it, but the record below documents what was studied.
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