An interventional study of AI-sourced gain-framed message (Component 1) and AI-sourced loss-framed message (Component 1) in Vaccination, Mental Health and Health Behavior, sponsored by Peking University. Not yet recruiting at 2 sites in China. Open to participants aged 10 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-10.
Sponsored by Peking University · Not applicable, Interventional, and Health services research
This study examines how different ways of presenting health information affect health-related understanding, decision-making, and behavior. It includes two connected research components: one focuses on vaccination-related decisions, and the other focuses on mental health and help-seeking. Participants will complete an online questionnaire and will be randomly assigned to different information conditions that vary in message framing, information source, social norms, and presentation format. The study will compare post-exposure decision intentions and behavioral responses across the assigned conditions. No medicines, vaccines, or medical devices will be administered as part of the study.
Health information can influence how people understand health risks, evaluate available options, and make health-related decisions. This prospective behavioral study will use an online questionnaire and a randomized parallel-group design to evaluate how different characteristics of health information affect health-related decision intention and behavioral responses.
The study consists of two connected components conducted in different participant populations and regions. The first component examines how the source and framing of vaccination-related information influence participants' evaluation, decision intention, trust, and subsequent behavioral choices. The second component examines how differently framed mental health information, source cues, and social norms influence mental health-related decision-making and help-seeking responses.
In each component, eligible participants will provide informed consent and will be randomly assigned through an online survey platform to one of several pre-specified information conditions or a comparison condition. Outcomes will be assessed through self-reported questionnaire measures and behavioral responses recorded by the survey platform, including the decision to view further information or proceed with an available follow-up action.
The study does not administer or evaluate the safety or efficacy of any drug, biological product, vaccine, or medical device. All study procedures will be conducted using a secure online platform in accordance with the approved study protocol and applicable ethical requirements.
967 studies on the registry are indexed under Health Behavior; 165 are open to participants now.
This study's planned enrollment of 102,000 is above the median of 150 across 824 interventional studies indexed under Health Behavior.
Browse Health Behavior studies →Peking University is the lead sponsor of 419 studies on the registry; 123 are open to participants now.
Compared within Health Behavior, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Psychological Well-Being. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Behavioral: AI-sourced gain-framed message (Component 1)
Behavioral: AI-sourced loss-framed message (Component 1)
Behavioral: AI-sourced normative message (Component 1)
Behavioral: AI-sourced structured message (Component 1)
Behavioral: AI-sourced expert-authority message (Component 1)
Behavioral: Official gain-framed message (Component 1)
Behavioral: Official loss-framed message (Component 1)
Behavioral: Official normative message (Component 1)
Behavioral: Official structured message (Component 1)
Behavioral: Official expert-authority message (Component 1)
Behavioral: Gain-framed peer message (Component 2)
Behavioral: Gain-framed expert message (Component 2)
Behavioral: Loss-framed peer message (Component 2)
Behavioral: Loss-framed expert message (Component 2)
Behavioral: Social-norm message (Component 2)
Participants view an AI-sourced message emphasizing the benefits of vaccination.
Participants view an AI-sourced message emphasizing the risks of not being vaccinated.
Participants view an AI-sourced message emphasizing social or public-health approval of vaccination.
Participants view an AI-sourced message explaining vaccination and booking procedures in a structured format.
Participants view an AI-sourced message attributed to professional or expert authority.
Participants view an official message emphasizing the benefits of vaccination.
Participants view an official message emphasizing the risks of not being vaccinated.
Participants view an official message emphasizing social or public-health approval of vaccination.
Participants view an official message explaining vaccination and booking procedures in a structured format.
Participants view an official message attributed to professional or expert authority.
Participants view a gain-framed message emphasizing the benefits of mental health help-seeking, with peer social cues.
Participants view a gain-framed message emphasizing the benefits of mental health help-seeking, attributed to an expert source.
Participants view a loss-framed message emphasizing the risks of not seeking mental health support, with peer social cues.
Participants view a loss-framed message emphasizing the risks of not seeking mental health support, attributed to an expert source.
Participants view a message presenting help-seeking as a common and socially approved behavior.
HPV vaccination intention
In the Hunan population, assessed immediately after exposure with one 5-point item: "I am willing to receive the HPV vaccine in the future." Responses range from 1 (strongly disagree) to 5 (strongly agree). Higher scores indicate stronger intention to receive the HPV vaccine.
Time frame: Immediately after exposure to the assigned health information condition (post-exposure questionnaire).
Professional mental health help-seeking intention
In Tongzhou students and primary caregivers, assessed using three 7-point items asking how likely the participant would be to seek help from a psychologist, a psychiatrist, and another doctor if experiencing persistent emotional distress or thoughts of self-harm. Scores range from 1 (definitely would not) to 7 (definitely would). The mean of the three items will be calculated; higher scores indicate stronger professional help-seeking intention.
Time frame: Immediately after exposure to the assigned health information condition (post-exposure questionnaire).
HPV vaccination booking-directed action
In the Hunan population, a binary behavioral outcome recorded by the online questionnaire platform after exposure. A positive response is defined as either selecting direct booking at the first decision point or agreeing to provide contact information for HPV vaccination booking at the end of the booking pathway. Viewing information without proceeding to booking or providing contact information is not counted as a positive response.
Time frame: During the same online session immediately after exposure to the assigned health information condition.
HPV vaccine trust
In the Hunan population, assessed with five HPV-adapted Vaccine Trust Gauge items covering vaccine safety, protection against serious illness, relative health risk, benefits versus risks, and effectiveness. Responses will be scored in the direction of greater trust using the prespecified VTG scoring and missing response rules. The item mean will be rescaled to 0-100; higher scores indicate greater trust.
Time frame: Immediately after exposure to the assigned health information condition.
Trust in HPV vaccine information sources
In the Hunan population, assessed with five Vaccine Trust Gauge-adapted items measuring trust in HPV vaccine recommendations from schools or official institutions, doctors or nurses, family or friends, classmates or peers, and social media. Responses will be scored using the same prespecified VTG rules. The item mean will be rescaled to 0-100; higher scores indicate greater trust.
Time frame: Immediately after exposure to the assigned health information condition.
HPV vaccination readiness (7C-based)
In the Hunan population, assessed using seven HPV-adapted 7C vaccination- readiness items covering calculation, collective responsibility, confidence in the system, confidence in vaccine safety, social conformity, convenience or constraints, and complacency. Items will be reverse scored where required and averaged so that higher scores indicate greater vaccination readiness.
Time frame: Immediately after exposure to the assigned health information condition.
Perceived susceptibility to HPV infection
In the Hunan population, assessed using the mean of three 5-point Health Belief Model items representing perceived susceptibility to HPV infection. Items will be reverse scored as specified in the analysis plan so that higher scores indicate greater perceived susceptibility.
Time frame: Immediately after exposure to the assigned health information condition.
Perceived severity of HPV infection
In the Hunan population, assessed using one reverse-scored 5-point Health Belief Model item concerning whether the health effects of HPV infection are not serious. The score will be transformed so that higher scores indicate greater perceived severity.
Time frame: Immediately after exposure to the assigned health information condition.
Perceived barriers to HPV vaccination
In the Hunan population, assessed using the mean of six 5-point Health Belief Model items concerning perceived drawbacks, cost, insufficient information, uncertain long-term side effects, sexual stigma, and sensitivity of the topic. Higher scores indicate greater perceived barriers to HPV vaccination.
Time frame: Immediately after exposure to the assigned health information condition.
Cues to action for HPV vaccination
In the Hunan population, assessed using the mean of two 5-point Health Belief Model items concerning exposure to media reports promoting HPV vaccination and the influence of a doctor's recommendation. Higher scores indicate stronger cues to action.
Time frame: Immediately after exposure to the assigned health information condition.
Help-seeking efficacy attitudes related to mental health
In Tongzhou students and primary caregivers, assessed using the Help-Seeking dimension of the Universal Mental Health Literacy Scale for Adolescents (UMHL-A). Five applicable items are used in students and four in caregivers. Items are scored on a 5-point scale, averaged, and rescaled to 0-100. Higher scores indicate more favorable help-seeking attitudes.
Time frame: Immediately after exposure to the assigned school-based health message.
Stigma-related attitudes toward mental health
In Tongzhou students and primary caregivers, assessed using the three-item Stigma dimension of the Universal Mental Health Literacy Scale for Adolescents (UMHL-A). Items are scored on a 5-point scale, averaged, and rescaled to 0-100 in the direction of less stigmatizing and more favorable attitudes.
Time frame: Immediately after exposure to the assigned school-based health message.
Intention to use generative AI for HPV vaccination information
In the Hunan population, assessed using two post-exposure 5-point items asking whether the participant is willing to use an AI chatbot to obtain further HPV vaccination information and whether generative AI would be used as one source of HPV vaccination information. Both items will be coded in the direction of greater intention and averaged.
Time frame: Immediately after exposure to the assigned health information condition.
Benevolence dimension of trust in generative AI for health information
In Hunan and Tongzhou participants, assessed using the three-item Benevolence dimension of the Human-Generative AI Trust Scale, adapted to HPV vaccination or mental health information. The items assess whether generative AI acts in the participant's best interest, is willing to understand the participant's needs and preferences, and will help to the best of its ability. Items use a 5-point response scale and are averaged; higher scores indicate greater benevolence-based trust.
Time frame: Immediately after exposure to the assigned health information condition.
Competence dimension of trust in generative AI for health information
In Hunan and Tongzhou participants, assessed using the three-item Competence dimension of the Human-Generative AI Trust Scale. The items assess whether generative AI can effectively support the participant in understanding health information, performs well in providing health information support, and has the expected functions for that role. Items use a 5-point response scale and are averaged; higher scores indicate greater competence-based trust.
Time frame: Immediately after exposure to the assigned health information condition.
Reciprocity or dependency dimension of trust in generative AI for health information
In Hunan and Tongzhou participants, assessed using the three-item Reciprocity or Dependency dimension of the Human-Generative AI Trust Scale. The items assess whether participants believe they can rely on generative AI, whether it can continue to support health decisions, and whether they refer to health information provided by generative AI. Items use a 5-point response scale and are averaged; higher scores indicate greater reciprocity-based trust.
Time frame: Immediately after exposure to the assigned health information condition.
Psychological resilience
In Tongzhou students and primary caregivers, assessed immediately after exposure using the 10-item Connor-Davidson Resilience Scale (CD-RISC-10). Each item is scored from 0 (not true at all) to 4 (true nearly all the time). The 10 item scores are summed to a total score ranging from 0 to 40; higher scores indicate greater psychological resilience. If the online platform stores responses as 1-5, scores will be recoded to 0-4 before summation.
Time frame: Immediately after exposure to the assigned school-based health message.
Plan to share: No
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From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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