An interventional study of General anesthesia and Local anesthesia/concious sedation in Posterior Circulation Brain Infarction, sponsored by Beijing Tiantan Hospital. Completed at 2 sites in China. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2023-05-19.
Sponsored by Beijing Tiantan Hospital · Not applicable, Interventional, and Other
There is few randomized controlled clinical to investigated the impact of anesthetic type on outcome in patients with acute ischemic stroke in posterior cerebral circulation. It is unknown whether the choice of anesthesia is impacted on the outcomes for these patients or not. The investigators will perform a randomized controlled pilot clinical trial of general anesthesia versus local anesthesia/conscious sedation to explore and find out a potential fact whether anesthetic type alters perioperative neurological function in patients with acute ischemic stroke in posterior cerebral circulation.
93 studies on the registry are indexed under Brain Infarction; 19 are open to participants now.
This study's enrollment of 93 is below the median of 134 across 67 interventional studies indexed under Brain Infarction.
Browse Brain Infarction studies →Beijing Tiantan Hospital is the lead sponsor of 489 studies on the registry; 293 are open to participants now.
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Exclusion Criteria:
Patients will be injected by propofol (adjusted by bispectral index scale ≥70 ) and /or remifentanil（0.01-0.06μg/kg/min）. Patients will maintain spontaneous breathing.
Procedure: Local anesthesia/concious sedation · Procedure: Spontaneous breath
Patients will be induced with remifentanil (0.2-0.8 μg/kg), propofol (1-2mg/kg) and rocuronium (0.6 mg/kg). Anesthesia will then be maintained keep the BIS between 40 and 60 with propofol and remifentanil. After tracheal intubation, patients will be kept with controlled ventilation.
Procedure: General anesthesia · Procedure: Controlled ventilation
Patients will be injected with propofol, remifentanil and muscular relaxant with controlled ventilation.
Patients will be injected with propofol and remifentanil.
Patients will be kept spontaneous breath.
Patient will be kept with controlled ventilation.
modified rankin score（mRS）
Modified rankin score（mRS）is used to evaluate the primary outcome. The scale of mRS is 0 to 6. The best neurological outcome is the mRS with 0, indicating no any symptom left, and a good neurological outcome is agreed with a mRS≤2. mRS of 6 is the worst, indicating death. mRS will be evaluated by outcomes assessor who is blinded to the grouping.
Time frame: post-procedural 90 days
Plan to share: Undecided
This study is completed, as verified in May 2023. You cannot join it, but the record below documents what was studied.
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