An interventional study of Internet-Delivered Cognitive Behavioral Therapy in Chronic Pain, Depressive Symptoms and Anxiety, sponsored by Uppsala University. Completed at 1 site in Sweden. Open to participants aged 16 Years to 70 Years. Per ClinicalTrials.gov, last updated 2020-05-27.
Sponsored by Uppsala University · Not applicable, Interventional, and Treatment
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Among 15 studies in Chronic Pain by Uppsala University — 3 open to participants now, 3 under way, none of them phase 3. Chronic Pain · Uppsala University.
Among the 15 studies in Chronic Pain by Uppsala University, this one is the only one that started in 2016, is one of 8 with no phase, and was the 3rd registered.
3,227 studies on the registry are indexed under Chronic Pain; 728 are open to participants now.
Browse Chronic Pain studies →3 of the 15 studies in Chronic Pain by Uppsala University are open now, in 1 country. Recruiting first, the newest first:
Uppsala University · Sites in Sweden
Ages 18–75
Uppsala University · Sites in Sweden
Ages 18–65
Uppsala University · Sites in Sweden
Ages 18+
By country, each count listing its studies:
Of the 486 Chronic Pain studies recruiting now, 239 (49%) set no upper age limit and 173 (36%) stop at 75 or younger; 43 take children under 18; 64 take healthy volunteers.
This study: 16 Years to 70 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
15 studies; the count open now beside each. This study's row is marked.
First in 2010; this study’s year is marked. 1 started in 2016.
This study's enrollment of 187 is above the median of 60 across 2,387 interventional studies indexed under Chronic Pain.
Median enrollment 103 across the 8 interventional studies, 96 across the 7 observational. Of the 10 that completed or were terminated, 0 (0%) have results posted.
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Uppsala University is the lead sponsor of 390 studies on the registry; 86 are open to participants now.
1 of the studies in Chronic Pain by Uppsala University that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06063902Uppsala UniversityLong-Term Opioid Therapy in Chronic Non-Cancer Pain: Risks and Benefits | 2027-01-14 |
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Among the 15 studies in Chronic Pain by Uppsala University, from their registry updates:
Nothing recorded among them since 2026-09-25.
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This study is a randomized controlled trial studying the efficacy of an iCBT treatment for patients with chronic pain and comorbid psychiatric distress. Half the participants will receive treatment at first, while the other half serve as a control group. After the first group has received treatment, the same program will be offered to participants in the control group. Treatment will be tailored on the level of individual participants, enabling individuals suffering a wide range of problems to be recruited. The treatment will consist of a 10-week guided self-help program, followed by a booster program and follow-up one year later. During the curse of the treatment the participants will be guided via text communication by a licensed psychologist or a candidate psychologist on their last year of studies.
The primary hypothesis is that an individually tailored CBT-treatment administered through the internet can be beneficial for patients suffering from chronic pain and comorbid psychiatric distress. The investigators expect that patients in the treatment group will show reduced levels of disability, depression and anxiety, while improving on scales measuring coping and quality of life.
Patients suffering from chronic pain often experience comorbid psychiatric distress. Cognitive behavioral therapy (CBT) has been shown to be effective in treating both these problems. However delivering relevant treatment can be difficult due to logistics, cost and lack of personnel with required competence. Delivering CBT though the internet (iCBT) is a novel approach, sidestepping logistical issues while lowering costs. This however, is an area were research is lacking, and though there are several studies showing iCBT to be efficacious in treating both pain and psychiatric conditions, research on a combined approach is scarce.
This study will primarily investigate whether an individually tailored CBT-treatment administered through the internet can be beneficial for patients suffering from chronic pain and comorbid psychiatric conditions. The project will also clarify whether a following booster-program, also administered tough the internet, is helpful in maintaining and increasing effects of the initial treatment. Lastly, analysis of possible mediating variables will be able to give insight into the internal workings of the treatment itself, further elucidating efficacy of specific interventions, data which will be useful in future developments of treatment design.
The treatment will be based on a previously developed program, devised to target depression and anxiety in patients with chronic pain. The treatment will consist of a 10-week period where participants would get access to a series of treatment modules, each addressing a separate problem area using CBT techniques. The treatment includes modules addressing depression, anxiety, panic, worry, insomnia, stress, trauma, communication skills, and relaxation. The booster program will be based on the initial treatment, but will shorter, focusing on repetition, strategies for maintenance, and coping with setbacks. The platform used is an existing platform employed by Smärtcentrum at Uppsala university hospital for delivering internet based treatments.
The study will be conducted using a randomized controlled trial with a between-group design. Participants will be randomized to two groups, were one group will gain access to iCBT treatment while the second group will be a wait-list control, and will gain access to the program once treatment of the active group is finished. Participants will assessed by a licensed psychologist, and treatment modules assigned based on their individual needs. In addition to online CBT modules, consisting of information, exercises and homework assignments, all participants will have regular contact by secure email-channel with a licensed psychologist or last-year psychology student under supervision. This contact will guide treatment, providing support, feedback on homework, and if necessary clarify treatment content and help with IT-related problems interfering with treatment adherence. After a year, participants will be invited to take part in a follow-up module, consisting of limited treatment recapitulation and evaluation.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
10 week, guided and individually tailored internet-delivered cognitive behavioral therapy.
Behavioral: Internet-Delivered Cognitive Behavioral Therapy
Wait list control group, receives treatment at later point.
Change from baseline in depressive symptoms
Self reported change in depressive symptoms, Montgomery-Åsberg Depression Rating Scale (MADRS-S) Swedish version, 9 items
Time frame: at 10 weeks
Change from baseline in depressive symptoms
Self reported change in depressive symptoms, Montgomery-Åsberg Depression Rating Scale (MADRS-S) Swedish version, 9 items
Time frame: at one-year
Change from baseline in psychosocial consequences of pain
Self reported psychosocial consequences of pain, West Haven-Yale Multidimensional Pain Inventory (WHY/MPI-S part 1), Swedish version, 22 items
Time frame: at 10 weeks
Change from baseline in psychosocial consequences of pain
Self reported psychosocial consequences of pain, West Haven-Yale Multidimensional Pain Inventory (WHY/MPI-S part 1), Swedish version, 22 items
Time frame: at one-year
Change from baseline in anxiety sensitivity
Self reported anxiety sensitivity, Anxiety Sensitivity Index (ASI), Swedish version, 16 items
Time frame: at 10 weeks
Change from baseline in anxiety sensitivity
Self reported anxiety sensitivity, Anxiety Sensitivity Index (ASI), Swedish version, 16 items
Time frame: at one-year
Change from baseline in symptoms of depression and anxiety
Self reported symptoms of depression and anxiety, Hospital Anxiety and Depression Scale (HADS), Swedish version, 14 items
Time frame: at 10 weeks
Change from baseline in symptoms of depression and anxiety
Self reported symptoms of depression and anxiety, Hospital Anxiety and Depression Scale (HADS), Swedish version, 14 items
Time frame: at one-year
Change from baseline in pain disability
Self reported pain disability, Pain Disability Index (PDI), Swedish version, 7 items
Time frame: at 10 weeks
Change from baseline in pain disability
Self reported pain disability, Pain Disability Index (PDI), Swedish version, 7 items
Time frame: at one-year
Change from baseline in quality of life
Self reported quality of life, Quality of Life Inventory (QOLI), Swedish version, 7 items
Time frame: at 10 weeks
Change from baseline in quality of life
Self reported quality of life, Quality of Life Inventory (QOLI), Swedish version, 7 items
Time frame: at one-year
Fear of pain due to movement
Self reported fear of movement, Tampa Scale of Kinesiophobia (TSK), Swedish version, 17 items
Time frame: Baseline only
Change from baseline in insomnia symptoms
Self reported insomnia symptoms, Insomnia Severity Index (ISI), Swedish version
Time frame: at 10 weeks
Change from baseline in insomnia symptoms
Self reported insomnia symptoms, Insomnia Severity Index (ISI), Swedish version
Time frame: at one-year
Change from baseline in PTSD symptoms
Self reported PTSD symptoms, Post-Traumatic Stress Disorder checklist 5 (PCL-5), Swedish version
Time frame: at 10 weeks
Change from baseline in PTSD symptoms
Self reported PTSD symptoms, Post-Traumatic Stress Disorder checklist 5 (PCL-5), Swedish version
Time frame: at one-year
Change from baseline in stress
Self reported stress, Shirom-Melomed Burnout Questionnaire (SMBQ), Swedish version
Time frame: at 10 weeks
Change from baseline in stress
Self reported stress, Shirom-Melomed Burnout Questionnaire (SMBQ), Swedish version
Time frame: at one-year
Change from baseline in GAD-symptoms
Self reported GAD-symptoms , Generalized Anxiety Disorder 7 (GAD-7), Swedish version
Time frame: at 10 weeks
Change from baseline in GAD-symptoms
Self reported GAD-symptoms , Generalized Anxiety Disorder 7 (GAD-7), Swedish version
Time frame: at one-year
Change from baseline in pain catastrophizing
Self reported pain catastrophizing, Pain Catastrophizing Scale (PCS), Swedish version
Time frame: at 5 weeks
Change from baseline in pain catastrophizing
Self reported pain catastrophizing, Pain Catastrophizing Scale (PCS), Swedish version
Time frame: at 10 weeks
Change from baseline in pain catastrophizing
Self reported pain catastrophizing, Pain Catastrophizing Scale (PCS), Swedish version
Time frame: at one-year
Change from baseline in coping strategies
Self reported coping strategies , Coping Strategies Questionnaire - Revised (CSQ-R), Swedish version
Time frame: at one-year
Change from baseline in coping strategies
Self reported coping strategies , Coping Strategies Questionnaire - Revised (CSQ-R), Swedish version
Time frame: at 5 weeks
Change from baseline in coping strategies
Self reported coping strategies , Coping Strategies Questionnaire - Revised (CSQ-R), Swedish version
Time frame: at 10 weeks
Change from baseline in pain acceptance
Self reported pain acceptance, Chronic Pain Acceptance Questionnaire (CPAQ), Swedish version
Time frame: at 5 weeks
Change from baseline in pain acceptance
Self reported pain acceptance, Chronic Pain Acceptance Questionnaire (CPAQ), Swedish version
Time frame: at 10 weeks
Change from baseline in pain acceptance
Self reported pain acceptance, Chronic Pain Acceptance Questionnaire (CPAQ), Swedish version
Time frame: at one-year
Change from baseline in self efficacy
Self reported pain related self efficacy, Pain Self Efficacy-2 (PSEQ-2), Swedish version
Time frame: at 5 weeks
Change from baseline in self efficacy
Self reported pain related self efficacy, Pain Self Efficacy-2 (PSEQ-2), Swedish version
Time frame: at 10 weeks
Change from baseline in self efficacy
Self reported pain related self efficacy, Pain Self Efficacy-2 (PSEQ-2), Swedish version
Time frame: at one-year
Treatment credibility rating
Self reported treatment credibility, Treatment Credibility Scale (TCS), Swedish version
Time frame: Baseline only
Ran from Sep 2016 to primary completion in May 2017, 8 months.
Of 1,295 non-industry interventional studies with no phase under Chronic Pain, half reached primary completion within 20 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 39. This study's 8 months is below that.
Counting every sponsor, half of 1,378 studies reached it within 20 months; a quarter within 9 and three quarters within 38.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in May 2020. You cannot join it, but the record below documents what was studied.
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