An observational study in Retinal Artery Occlusion, Magnetic Resonance Imaging and Diagnosis, sponsored by Fondation Ophtalmologique Adolphe de Rothschild. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-01-05.
Sponsored by Fondation Ophtalmologique Adolphe de Rothschild · Observational
Central retinal artery occlusions (CRAO) are the equivalent of an ischemic stroke at the retinal level. They share the same risk factors and common pathology. The diagnosis of a CRAO is clinically based on the sudden occurrence of a decrease in deep visual acuity with fundamentally signs of reactive ischemia.
Small studies have highlighted the value of cerebral MRI (Magnetic Resonance Imaging) in CRAO with almost 25% of ischemic strokes found on diffusion sequences and the demonstration of a correlation between anomalies in diffusion sequence and the probability of a pathology with a high risk of recurrence (carotid stenosis or emboligenic cardiopathy). But there are usually few radiological signs that allow a direct positive diagnosis of CRAO, an etiologic diagnosis or a prognosis. This descriptive study will focus on CRAO at the diagnostic and post-treatment phases in the short and medium term, in order to (i) identify imaging etiologic signs of CRAO with specific sequences from a 3 Tesla MRI, (ii) identify positive diagnostic signs of CRAO with the same specific sequences, (iii) correlate these signs with the visual prognosis one month after the CRAO.
31 studies on the registry are indexed under Retinal Artery Occlusion; 7 are open to participants now.
This study's enrollment of 63 is below the median of 388 across 14 observational studies indexed under Retinal Artery Occlusion.
Browse Retinal Artery Occlusion studies →Fondation Ophtalmologique Adolphe de Rothschild is the lead sponsor of 316 studies on the registry; 78 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult patients hospitalized for CRAO ≤ 48 hours.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
- to 3 Tesla MRI
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients will be hospitalized for suspicion of CRAO. An "optimized" MRI will be performed with specific sequences: 3D T1 MSDE (Motion Sensitized Driven Equilibrium) "dark blood"; 3D Optimized diffusion centered on the optic nerves; 3D PD T1 after injection. A consultation of ophthalmology and a control MRI will be carried out one month after the CRAO. Again, specific sequences will be added: 3D T1 MSDE (Motion Sensitized Driven Equilibrium) "dark blood"; 3D Optimized diffusion centered on the optic nerves; DTI (Diffusion Tensor Imaging); 3D PD T1 after injection.
Contrast enhancement of the ophthalmic artery
Binary variable (yes/no)
Time frame: Baseline
Presence of a thrombus
Binary variable (yes/no)
Time frame: Baseline
Presence of an arterial stenosis of the supra aortic trunks
Binary variable (yes/no)
Time frame: Baseline
Hypersignal of the ophthalmic artery in diffusion
Binary variable (yes/no)
Time frame: Baseline
Restriction of the apparent diffusion coefficient (ADC) at the optic nerve level and at the papilla level
Binary variable (yes/no)
Time frame: Baseline
Plan to share: No
No publications or documents are linked to this record.
Ran from Dec 2017 to primary completion in Oct 2023, 70 months.
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This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
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