An observational study in Retinal Artery Occlusion, Central Retinal Artery Occlusion and Retinal Ischemia, sponsored by Germans Trias i Pujol Hospital. Not yet recruiting at 1 site in Spain. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-11-06.
Sponsored by Germans Trias i Pujol Hospital · Observational
Retinal stroke is a time-dependent neurovascular emergency associated with severe visual loss, increased risk of cerebrovascular events and substantial variability in clinical management.
The GEIR Registry is a nationwide, multicentre, ambispective observational registry comprising retrospective and prospective data collected from participating hospitals throughout Spain.
Despite growing recognition of retinal artery occlusion as the ocular equivalent of acute ischaemic stroke, important uncertainties remain regarding its epidemiology, pathophysiology, healthcare delivery, retinal viability and optimal treatment strategies. Current evidence is largely derived from retrospective cohorts, single-centre studies and a limited number of randomised clinical trials. Furthermore, no nationwide multicentre retinal stroke registry currently exists in Spain. The GEIR Registry was established to address these knowledge gaps through the creation of a national clinical and translational research platform dedicated to retinal stroke.
Methods and analysis The GEIR Registry is a nationwide, multicentre, ambispective observational registry comprising retrospective and prospective data collected from participating hospitals throughout Spain.
Consecutive patients presenting with retinal stroke, including central retinal artery occlusion, branch retinal artery occlusion, cilioretinal artery occlusion and paracentral acute middle maculopathy, are eligible for inclusion.
Clinical information is collected using a the institution's REDCap electronic data base specifically designed for the registry and includes demographic characteristics, vascular risk factors, acute stroke pathway metrics, neurovascular investigations, reperfusion therapies, laboratory biomarkers, secondary prevention strategies, neurological outcomes, ophthalmological assessments and longitudinal optical coherence tomography (OCT) biomarkers.
The registry aims to characterise retinal stroke epidemiology, healthcare delivery and long-term outcomes, while providing a unique platform for investigating retinal ischaemia, imaging biomarkers of retinal viability and predictors of visual recovery. Statistical analyses include descriptive epidemiological analyses, multivariable regression models and longitudinal outcome assessments.
Ethics and dissemination The registry will be conducted in accordance with the Declaration of Helsinki, applicable European and Spanish data protection regulations and local ethics committee approvals. Written informed consent will be obtained for prospective participants. Data will be pseudonymised and stored within a secure REDCap infrastructure.
Results generated from the registry will be disseminated through peer-reviewed publications, scientific conferences and collaborative multicentre research initiatives. The GEIR Registry is intended to serve as a long-term national infrastructure supporting clinical, epidemiological and translational research in retinal stroke.
31 studies on the registry are indexed under Retinal Artery Occlusion; 7 are open to participants now.
This study's planned enrollment of 500 is above the median of 388 across 14 observational studies indexed under Retinal Artery Occlusion.
Browse Retinal Artery Occlusion studies →Germans Trias i Pujol Hospital is the lead sponsor of 89 studies on the registry; 12 are open to participants now.
Counted across the registry records on this site, refreshed daily.
patients affected of retinal stroke
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Age >18 years.
Clinical diagnosis of retinal stroke.
Symptom onset or last known normal vision within the previous 24 hours.
Absence of pre-existing ocular pathology severely limiting visual acuity in the affected eye.
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Exclusion Criteria:
national research registry platform
To establish the first nationwide retinal stroke registry in Spain.
Time frame: 2026.12 - 2030.12
To estimate the epidemiological burden of retinal stroke.
To estimate the national epidemiological burden of retinal stroke in Spain.
Time frame: 2026.12 - 2030.12
To characterise healthcare pathways and access to reperfusion therapies.
To characterise national healthcare pathways and access to reperfusion therapies in Spain
Time frame: 2026.12 - 2030.12
To describe the natural history of retinal stroke.
Retinal stroke natural history in Spain
Time frame: 2026.12 - 2030.12
To identify clinical, neurovascular and imaging predictors of visual recovery.
searching imaging predictors of visual recovery
Time frame: 2026.12 - 2030.12
To investigate OCT biomarkers associated with retinal viability and treatment response. [CEIC GEIR HUGTiP | Word] and precise the time of retinal ischemia
searching OCT biomarkers of retinal viability
Time frame: 2026.12 - 2030.12
Plan to share: No — undecided
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.
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Germans Trias i Pujol Hospital