CompletedNCT03304483SpartathlonUpdated Jul 20, 2023

Cardiovascular Responses to Spartathlon Running

An interventional study of 246-km running in Disorder Heart, sponsored by Aristotle University Of Thessaloniki. Completed at 1 site in Greece. Open to participants aged 18 Years to 67 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-07-20.

Sponsored by Aristotle University Of Thessaloniki · Not applicable, Interventional, and Screening

Phase: Not applicable
Study type: Interventional
Enrollment: 50
Allocation: Not applicable
Ages: 18 Years to 67 Years
Sex: All

Study summary

The aim of this study is to examine the cardiovascular effects of ultramarathon running and their relation to performance.

Read the detailed description

The purpose of the study is to determine the changes of cardiovascular morphology and function after an ultramarathon race. 50 entrants to the "Spartathlon 2017" 246-km running race will participate in the study. Cardiac and arterial morphology and function tests will be conducted one day before the race and within 20 minutes of race completion.

Conditions studied

Disorder Heart

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Heart Diseases 3,673

In context

Heart Diseases

3,673 studies on the registry are indexed under Heart Diseases; 458 are open to participants now.

This study's enrollment of 50 is below the median of 100 across 1,785 interventional studies indexed under Heart Diseases.

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Lead sponsor

Aristotle University Of Thessaloniki is the lead sponsor of 281 studies on the registry; 57 are open to participants now.

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Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 18 Years to 67 Years
Sexes eligible: All
Accepts healthy volunteers: Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

Runners at least 18 years old, healthy and sufficiently trained.
Runners being accepted to participate in the Spartathlon race according to the eligibility criteria (http://www.spartathlon.gr/en/registration-en.html)
Runners who will volunteer to be examined pre- and post the race

Exclusion criteria

Exclusion Criteria:

Runners with chronic diseases
Runners receiving any medication

Study design

Phase: Not applicable
Primary purpose: Screening
Allocation: Not applicable
Intervention model: Single group
Masking: None (open label)
Enrollment: 50 participants (actual)

Study arms

Experimental
Athletes
246-km running
Other: 246-km running

Interventions

Other246-km running
Spartathlon 2017

What researchers measure

Primary outcomes

Change of right ventricular function after one day ultra-marathon running
Echocardiographic study of left ventricular function
Time frame: before and after 1 day running

Secondary outcomes

Change of left ventricular function after one day ultra-marathon running
Echocardiographic study of left ventricular function
Time frame: before and after 1 day running
Change of carotid artery function after one day ultra-marathon running
Echocardiographic study of carotid arteries
Time frame: before and after 1 day running

Study locations

1 site

Laboratory of Sports Medicine
Thessaloniki, 546 35, Greece

References and documents

Publications

Seedhouse EL, Walsh ML, Blaber AP. Heart rate, mean arterial blood pressure, and pulmonary function changes associated with an ultraendurance triathlon. Wilderness Environ Med. 2006 Winter;17(4):240-5. doi: 10.1580/pr27-05-r1.1. PubMed 17219787 ↗
Millet GP, Millet GY. Ultramarathon is an outstanding model for the study of adaptive responses to extreme load and stress. BMC Med. 2012 Jul 19;10:77. doi: 10.1186/1741-7015-10-77. PubMed 22812424 ↗
Cote AT, Phillips AA, Foulds HJ, Charlesworth SA, Bredin SS, Burr JF, Koehle MS, Warburton DE. Sex differences in cardiac function after prolonged strenuous exercise. Clin J Sport Med. 2015 May;25(3):276-83. doi: 10.1097/JSM.0000000000000130. PubMed 25010150 ↗
Jee H, Park J, Oh JG, Lee YH, Shin KA, Kim YJ. Effect of a prolonged endurance marathon on vascular endothelial and inflammation markers in runners with exercise-induced hypertension. Am J Phys Med Rehabil. 2013 Jun;92(6):513-22. doi: 10.1097/PHM.0b013e31829232db. PubMed 23685440 ↗
Blaber AP, Walsh ML, Carter JB, Seedhouse EL, Walker VE. Cardiopulmonary physiology and responses of ultramarathon athletes to prolonged exercise. Can J Appl Physiol. 2004 Oct;29(5):544-63. doi: 10.1139/h04-035. PubMed 15507692 ↗

Individual participant data

Plan to share: No — No personal details will be shared. Only the results of the measurements will be available

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Jul 20, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT03304483
Lead sponsor: Aristotle University Of Thessaloniki
Responsible party: Evangelia Kouidi (Cardiologist, Professor of Sports Medicine, Aristotle University Of Thessaloniki) — Principal investigator
First posted: Oct 9, 2017
Start date: Sep 29, 2017
Primary completion: Dec 30, 2019
Completion: Jun 30, 2021
Last update: Jul 20, 2023

Study contacts

Evangelia Kouidi, Professor

principal investigator · Aristotle University of Thessaloniki, Greece

Oversight

FDA-regulated drug: No
FDA-regulated device: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2023. You cannot join it, but the record below documents what was studied.

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